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Thromb Haemost 1972; 27(02): 292-299
DOI: 10.1055/s-0038-1649368
Originalarbeiten — Original Articles — Travaux Originaux
Schattauer GmbH

The Dual Sample Aggregometer

A New Instrument Adapted for Serial Testing of Antiaggregating Agents
J Gerloff   *)
1   Department of Medicine, University of Colorado Medical Center, Denver/Colorado, U.S.A
,
K. N von Kaulla
1   Department of Medicine, University of Colorado Medical Center, Denver/Colorado, U.S.A
› Author AffiliationsSupported by a grant-in-aid (HE 9985) from the National Heart and Lung Institute USPHS.
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Publication History

Publication Date:
29 June 2018 (online)

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Summary

An improved platelet aggregometer is described which permits the simultaneous recording of two aggregation curves obtained under technically strictly identical conditions which can be recorded with any single pen recorder. The curves are superimposed thus facilitating the visual or mathematical assessment of differences in the aggregation pattern. The instrument is particularly suitable for serial testing of aggregation inhibiting agents. It is equally suitable in the conventional way as any single channel aggregometer for routine testing of platelet aggregation.

*) Student fellow on leave from the University of Erlangen, Germany; supported by stipend of the Behring-Werke, Germany.


 

  • References

  • 1 Born G. V. R. Quantitative investigation into the aggregation of blood platelets. J. Physiol 162: 67P 1962;
    PubMedGoogle Scholar
  • 2 Broersma R, Mammen E, Steinman R, Rosenberg J. C. Detection of antibodies to transplantation antigens by platelet aggregometry. J. Surg. Res 11: 173-178. 1971;
    CrossrefPubMedGoogle Scholar
  • 3 Cronberg S. Evaluation of platelet aggregation. Coagulation 03: 139-151. 1970;
    PubMedGoogle Scholar
  • 4 Cuthbertson W. F. G, Mills D. C. B. A miniature nephelometer for the study of platelet clumping. J. Physiol 168: 29-31. 1963;
    CrossrefPubMedGoogle Scholar
  • 5 Juergens R, Braunsteiner H. Zur Pathogenese der Thrombose. Schweiz, med. Wschr 80: 1388-1394. 1950;
    PubMedGoogle Scholar
  • 6 von Kaulla K. N. On the in vitro mechanism of synthetic fibrinolytic agents. In: The Chemical Control of Fibrinolysis - Thrombolysis: Theory and Clinical Application. Schor J. M. ed. 1-41 Wiley-Interscience; New York: 1970
    Google Scholar
  • 7 von Kaulla K. N. (ed.) Coagulation Problems in Transplanted Organs. C.C. Thomas; Springfield: (Contains several contributions to the subject). 1972
    Google Scholar
  • 8 von Kaulla K. N, Husemann E. Über Beziehungen der Molekülgröße und -gestalt zur physiologischen Wirkung. Experientia (Basel) 02: 222-223. 1946;
    PubMedGoogle Scholar
  • 9 O’Brien J. R. Platelet aggregation. Part II. Some results from a new method of study. J. clin. Path 15: 452-455. 1962;
    PubMedGoogle Scholar