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Thromb Haemost 1977; 37(02): 210-215
DOI: 10.1055/s-0038-1649221
Original Article
Schattauer GmbH

A New Method for the Determination of Plasma Activators of Fibrinolysis

R Margalit
1   Clinical Research Laboratory, Department of Medicine B, Rothschild University Hospital and the Department of Biology, Technion – Israel Institute of Technology, Haifa, Israel.
,
E Gidron
1   Clinical Research Laboratory, Department of Medicine B, Rothschild University Hospital and the Department of Biology, Technion – Israel Institute of Technology, Haifa, Israel.
,
Y Shalitin
1   Clinical Research Laboratory, Department of Medicine B, Rothschild University Hospital and the Department of Biology, Technion – Israel Institute of Technology, Haifa, Israel.
› Author Affiliations
Further Information

Publication History

Received 17 June 1976

Accepted 20 December 1976

Publication Date:
03 July 2018 (online)

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Summary

The term “effective activator” of plasminogen is proposed, to denote the resultant of activator-antiactivator interaction, and a method for the determination of the level of these activators is described. By adding axcess plasminogen to the euglobulin fraction of plasma the influence of the level of endogenous plasminogen and of the antiplasmin is eliminated. It is shown that the level of fibrinogen has very little bearing on the results. An effective activator unit is defined as equal to 1 CTA unit of urokinase activity on a fibrinogen-plasminogen substrate.

 

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