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Thromb Haemost 1972; 28(03): 431-439
DOI: 10.1055/s-0038-1649026
Original Article
Schattauer GmbH

Effect of Plasma and Platelet Concentrate Infusions on Factor VIII, Platelet Adhesiveness, and Bleeding Time in Bleeder Swine

C. N Cornell
1   Departments of Agricultural Chemistry and Pharmacology of the University of Missouri, Columbia, Missouri 65201
,
R. G Cooper
1   Departments of Agricultural Chemistry and Pharmacology of the University of Missouri, Columbia, Missouri 65201
,
M. E Muhrer
1   Departments of Agricultural Chemistry and Pharmacology of the University of Missouri, Columbia, Missouri 65201
,
S Garb
1   Departments of Agricultural Chemistry and Pharmacology of the University of Missouri, Columbia, Missouri 65201
› Author Affiliations
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Publication History

Publication Date:
29 June 2018 (online)

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Summary

Bleeder swine are characterized by a prolonged bleeding time, decreased factor VIII levels or reduced platelet adhesiveness or both, and a factor VIII response to infusion of plasma or serum similar to that described in von Willebrand’s disease. In this study the factor VIII response of bleeder swine infused with fresh non-glass-contact pig plasma was similar to that reported in previous experiments after infusion of plasma that was frozen and stored for a variable period of time before use or was not free of glass contact. There was no beneficial effect on platelet adhesiveness. Following platelet concentrate infusion, there was no sustained normalization of platelet adhesiveness, although elevations into the normal range occurred at varying intervals after platelet infusion in two of three pigs investigated. Infusion of factor VIII-deficient plasma from a canine hemophiliac elicited a factor VIII response similar to that described in von Willebrand’s disease patients infused with plasma from factor VIII-deficient human hemophiliacs. In none of these experiments was there any apparent correction of the bleeding time.

 

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