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Thromb Haemost 1972; 28(03): 351-358
DOI: 10.1055/s-0038-1649018
Original Article
Schattauer GmbH

The Effects of Some Synthetic Compounds on In Vitro Fibrinolytic Activity Measured by Different Methods and the Relevance to Activity In Vivo

A.J Baillie   **
1   From Inveresk Research International, Musselburgh, Scotland
,
A. K Sim
1   From Inveresk Research International, Musselburgh, Scotland
› Author Affiliations
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Publication History

Publication Date:
24 July 2018 (online)

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Summary

The activity of several synthetic compounds, rated from good to poor (or inactive) fibrinolytic activators, has been assessed by two different commonly-used in vitro methods. Compounds shown to be active over a narrow concentration range in the hanging clot test were shown to be inhibitors of plasmin and trypsin in the casein-olytic test. The inhibitory activity of these compounds was shown to increase with increasing substrate concentration and apparent activity in the hanging clot test. Possible explanations and relevance of these observations are discussed.

** Present address: Department of Pharmaceutical Technology, University of Strathclyde, Glasgow, Scotland.


 

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