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Thromb Haemost 1978; 40(01): 037-042
DOI: 10.1055/s-0038-1648632
Original Article
Schattauer GmbH Stuttgart

Platelet Monoamine Oxidase and Epinephrine-Induced Platelet Aggregation

Ennio C Rossi
The Departments of Medicine and Biochemistry, Northwestern University School of Medicine, Chicago, Illinois 60611, U.S.A.
,
Gerlinde Louis
The Departments of Medicine and Biochemistry, Northwestern University School of Medicine, Chicago, Illinois 60611, U.S.A.
,
Martha Bieber
The Departments of Medicine and Biochemistry, Northwestern University School of Medicine, Chicago, Illinois 60611, U.S.A.
,
E Albert Zeller
The Departments of Medicine and Biochemistry, Northwestern University School of Medicine, Chicago, Illinois 60611, U.S.A.
› Author Affiliations
Further Information

Publication History

Received 15 November 1977

Accepted 04 March 1978

Publication Date:
12 July 2018 (online)

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Summary

Platelet MAO activity and the aggregation response to epinephrine, ADP, and collagen were measured in normal subjects. There was a direct correlation between the amount of platelet MAO activity and the per cent aggregation induced by 1 and 2 μM epinephrine. There were lesser correlations between platelet MAO and ADP or collagen-induced aggregation. These findings suggest that platelet MAO may play a role in determining the response of human platelets to epinephrine.

 

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