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Thromb Haemost 1976; 35(02): 295-304
DOI: 10.1055/s-0038-1647922
Original Article
Schattauer GmbH

The Effect of Antithrombin III on the Activity of the Coagulation Factors VII, IX and X

B Østerud
1   Institute of Medical Biology, University of Tromsø, Norway, Research Department, AB Kabi, Stockholm, Sweden and Department of Medicine A, Aker Hospital, Oslo, Norway
,
M Miller-Andersson
1   Institute of Medical Biology, University of Tromsø, Norway, Research Department, AB Kabi, Stockholm, Sweden and Department of Medicine A, Aker Hospital, Oslo, Norway
,
U Abildgaard
1   Institute of Medical Biology, University of Tromsø, Norway, Research Department, AB Kabi, Stockholm, Sweden and Department of Medicine A, Aker Hospital, Oslo, Norway
,
H Prydz
1   Institute of Medical Biology, University of Tromsø, Norway, Research Department, AB Kabi, Stockholm, Sweden and Department of Medicine A, Aker Hospital, Oslo, Norway
› Author Affiliations
Further Information

Publication History

Received 22 June 1975

Accepted 26 August 1975

Publication Date:
02 July 2018 (online)

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Summary

Antithrombin III, purified to homogeneity according to Polyacrylamide gel disc electrophoresis and immunoelectrophoresis, inhibited the activity of purified factor IXa and Xa, whereas factor VII was not inhibited either in the active or in the native form.

Antithrombin III is the single most important inhibitor of factor Xa in plasma. Factor Xa does not, however, reduce the activity of antithrombin III against thrombin.

 

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