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Thromb Haemost 1974; 32(02/03): 465-467
DOI: 10.1055/s-0038-1647714
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Action of Trypsin on Amidinated Fibrinogen

H. M Phillips
1   Department of Biochemistry, University of Arkansas Medical Center, Little Rock, Arkansas 72201
,
J Lyndal York
1   Department of Biochemistry, University of Arkansas Medical Center, Little Rock, Arkansas 72201
› Author Affiliations
Further Information

Publication History

Received 07 May 1974

Accepted 25 June 1974

Publication Date:
30 June 2018 (online)

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Summary

A study of the action of trypsin on fibrinogen with lysine side chains chemically blocked by amidination was undertaken to determine whether trypsin attacks arginine or lysine linkages in fibrinogen in order to render it nonclottable. The data suggests that trypsin attacks arginine site(s).

 

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