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Thromb Haemost 1974; 32(02/03): 341-349
DOI: 10.1055/s-0038-1647703
Original Article
Schattauer GmbH

Fibrinolytic Activity in Rat Anaphylaxis

László Fésüs
1   Department of Pathophysiology, University Medical School, 4012 Debrecen, Hungary, and National Institute of Arthritis, Metabolism and Digestive Diseases, National Institute of Health, Public Health Service, U.S. Department of Health, Education and Welfare, Bethesda, Maryland 20014
,
Éva Ölveti
1   Department of Pathophysiology, University Medical School, 4012 Debrecen, Hungary, and National Institute of Arthritis, Metabolism and Digestive Diseases, National Institute of Health, Public Health Service, U.S. Department of Health, Education and Welfare, Bethesda, Maryland 20014
,
Béla Csaba
1   Department of Pathophysiology, University Medical School, 4012 Debrecen, Hungary, and National Institute of Arthritis, Metabolism and Digestive Diseases, National Institute of Health, Public Health Service, U.S. Department of Health, Education and Welfare, Bethesda, Maryland 20014
,
László Muszbek
1   Department of Pathophysiology, University Medical School, 4012 Debrecen, Hungary, and National Institute of Arthritis, Metabolism and Digestive Diseases, National Institute of Health, Public Health Service, U.S. Department of Health, Education and Welfare, Bethesda, Maryland 20014
› Author Affiliations
Further Information

Publication History

Received 28 March 1974

Accepted 20 June 1974

Publication Date:
04 September 2018 (online)

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Summary

The activity of fibrinolytic system measured by different methods and the concentration of plasma fibrinogen were determined in rats suffering mild or severe active anaphylactic shock.

In severe anaphylactic shock of Bordetella Pertussis Vaccine pretreated animals, the plasminogen activator content was markedly enhanced and the fibrinolytic activity significantly increased; however, the total inhibitor capacity did not change. The fall in fibrinogen concentration was only moderate. Similar but minor enhancement of fibrinolysis could be observed in mild anaphylaxis.

The results suggest that the activated plasminogen-plasmin system may contribute to the development of severe anaphylactic outcome in the rat. The possible pathogenic mode is discussed.

 

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