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Thromb Haemost 1978; 39(02): 411-425
DOI: 10.1055/s-0038-1646701
Original Article
Schattauer GmbH Stuttgart

Specific Inhibition of Platelet Agglutination and Aggregation by Aromatic Amidino Compounds

J D Geratz
The Department of Pathology, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, North Carolina 27514, U.S.A.
,
R R Tidwell
The Department of Pathology, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, North Carolina 27514, U.S.A.
,
K M Brinkhous
The Department of Pathology, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, North Carolina 27514, U.S.A.
,
S F Mohammad
2   The Department of Pathology, Memorial Hospital, Pawtucket, Rhode Island 02860, U.S.A.
,
O Dann
3   Institut für Pharmazie und Lebensmittelchemie, Friedrich-Alexander-Universität, Erlangen, Frankfurt (M), Federal Republic of Germany
,
H Loewe
4   Hoechst AG, Frankfurt (M), Federal Republic of Germany
› Author Affiliations
Further Information

Publication History

Received 03 February 1977

Accepted 12 August 1977

Publication Date:
12 July 2018 (online)

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Summary

A series of aromatic amidino compounds were investigated for their inhibitory effect on platelet agglutination and platelet aggregation. Agglutination of fresh or fixed platelets was produced by bovine plasma or by human plasma in combination with ristocetin, while aggregation of fresh platelets was induced by ADP, thrombin or collagen. Highly effective inhibitors were found for both types of platelet clumping, but there was no parallelism between the inhibitory activities in the two test systems. 5-(5-amidino-2-benzimidazolyl)-2-(4-hydroxyben-zene)benzimidazole suppressed agglutination exclusively. Pentamidine, on the other hand, strongly blocked the aggregation reactions, but did not interfere with agglutination, even at high concentrations. Compounds which inhibited aggregation also prevented the liberation of serotonin from the platelets.

 

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