Download PDF
Thromb Haemost 1978; 39(02): 312-321
DOI: 10.1055/s-0038-1646691
Original Article
Schattauer GmbH Stuttgart

The Role of Endothelial Cell Injury and Platelet Response in Atherogenesis[*]

Laurence A Harker
The Departments of Medicine and Pathology, University of Washington School of Medicine, Seattle, Washington 98195, U.S.A.
,
Russell Ross
The Departments of Medicine and Pathology, University of Washington School of Medicine, Seattle, Washington 98195, U.S.A.
,
John A Glomset
The Departments of Medicine and Pathology, University of Washington School of Medicine, Seattle, Washington 98195, U.S.A.
› Author Affiliations
Further Information

Publication History

Publication Date:
12 July 2018 (online)

  PDF Download  Permissions and Reprints

* Presented at the VIth Congress on Thrombosis and Haemostasis, Philadelphia 1977


 

  • References

  • 1 Baumgartner HR, Studer A. 1977. Platelet factors and the proliferation of vascular smooth muscle cells. Atherosclerosis IV. Proceedings of the IVth International Symposium on Atherosclerosis, Tokyo 1976. Springer; Berlin:
    Google Scholar
  • 2 Baumgartner HR. 1974. The subendothelial surface and thrombosis. In: E. Deutsch K. M. Brink-Hous K. Lechner S. Hinnom (Eds.) Thrombosis: Pathogenesis and Clinical Trials, F. K. Schattauer-Verlag; Stuttgart: p 91
    Google Scholar
  • 3 Bjorkerud S, Bondjer G. 1971; Arterial repair and atherosclerosis after mechanical injury. I. Permeability and light microscopic characteristics of endothelium in non-atherosclerotic and atherosclerotic lesions. Atherosclerosis 13: 355
    CrossrefPubMedGoogle Scholar
  • 4 Booyse FM, Sedlak BJ, Rafelson Jr ME. 1975; Culture of arterial endothelial cells. Characterization and growth of bovine aortic cells. Thrombosis et Diathesis Haemorrhagica 34: 825
    PubMedGoogle Scholar
  • 5 Didisheim PT, Kazmier FJ, Fuster V. 1974; Platelet inhibition in the management of thrombosis. Thrombosis et Diathesis Haemorrhagica 32: 21
    PubMedGoogle Scholar
  • 6 Duguid JB. 1949; Pathogenesis of arteriosclerosis. Lancet 2: 925
    PubMedGoogle Scholar
  • 7 French JE. 1966; Atherosclerosis in relation to the structure and function of the arterial intima, with special reference to the endothelium. International Review of Experimental Pathology 5: 253
    PubMedGoogle Scholar
  • 8 Friedman RJ, Stemerman MB, Spaet TH. Moore S Gauldie J 1976; The effect of thrombocytopenia on arteriosclerotic plaque formation. Federation Proceedings 35: 207 a
    PubMedGoogle Scholar
  • 9 Fuster V, Bowie EJW, Lewis JC. 1977; The von Willebrand pig as a model for atherosclerosis research. Thrombosis and Haemostasis 38: 55
    PubMedGoogle Scholar
  • 10 Gaynor E, Bouvier CA, Spaet TH. 1970; Vascular lesions: possible pathogenetic basis of the generalized Shwartzman reaction. Science 170: 986
    CrossrefPubMedGoogle Scholar
  • 11 Gimbrone Jr MA, Cotran RS, Folkman J. 1974; Human vascular endothelial cells in culture: Growth and DNA synthesis. Journal of Cell Biology 60: 673
    CrossrefPubMedGoogle Scholar
  • 12 Harker L, Ross R, Slichter S, Scott C. 1976; Homocystine-induced arteriosclerosis: The role of endothelial cell injury and platelet response in its genesis. Journal of Clinical Investigation 58: 731
    CrossrefPubMedGoogle Scholar
  • 13 Harker LA, Slichter SJ, Scott CR, Ross R. 1974; Homocystinemia. Vascular injury and arterial thrombosis. New England Journal of Medicine 291: 537
    CrossrefPubMedGoogle Scholar
  • 14 Harker LA, Striker GE, Wall RT, Quadracci L. 1977; Platelet reactivity to blood vessel cells: Inhibition by endothelial cells. Clinical Research 25: 518 A
    PubMedGoogle Scholar
  • 15 Haudenschild CC, Cotran RS, Gimbrone Jr MA, Folkman J. 1975; Fine structure of vascular endothelium in culture. Journal of Ultrastructural Research 50: 2232
    PubMedGoogle Scholar
  • 16 Haust MD. 1970. Injury and repair in the pathogenesis of atherosclerotic lesions. In: Jones RJ. (ed.) Atherosclerosis. Springer-Verlag; New York: p 12
    Google Scholar
  • 17 Jaffe EA, Hoyer LW, Nachman RL. 1973; Synthesis of antihemophilic factor antigen by cultured human endothelial cells. Journal of Clinical Investigations 52: 2757
    CrossrefPubMedGoogle Scholar
  • 18 Minick CR, Murphy GE. 1973; Experimental induction of atheroarteriosclerosis by the synergy of allergic injury to arteries and lipid-rich diet. II. Effect of repeatedly injected foreign protein in rabbits fed a lipid-rich, cholesterol-poor diet. American Journal of Pathology 73: 265
    PubMedGoogle Scholar
  • 19 Moncada S, Gryglewski R, Bunting S, Vane JR. 1976; An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature 263: 663
    CrossrefPubMedGoogle Scholar
  • 20 Moncada S, Higgs EA, Vane JR. 1977; Human arterial and venous tissues generate prostacyclin (prostaglandin X), a potent inhibitor of platelet aggregation. Lancet 291: 18
    PubMedGoogle Scholar
  • 21 Moore S. 1973; Thromboatherosclerosis in normolipemic rabbits. A result of continued endothelial damage. Laboratory Investigations 29: 478
    PubMedGoogle Scholar
  • 22 Moore S, Friedman RJ, Singal DP, Gauldie J, Blajchman M. 1976; Inhibition of injury-induced thromboatherosclerotic lesions by antiplatelet serum in rabbits. Thrombosis et Diathesis Haemorrhagica 35: 70
    PubMedGoogle Scholar
  • 23 Mustard JF, Packham MA. 1975; The role of blood and platelets in atherosclerosis and the complications of atherosclerosis. Thrombosis et Diathesis Haemorrhagica 33: 444
    PubMedGoogle Scholar
  • 24 Mustard JF, Packham MA. 1970; Factors influencing platelet function: Adhesion, release and aggregation. Pharmacological Review 22: 97
    PubMedGoogle Scholar
  • 25 Nelson RD, Quie PG, Simmons RL. 1975; Chemotaxis under agarose: A new and simple method for measuring chemotaxis and spontaneous migration of human polymorphonuclear leukocytes and monocytes. Journal of Immunology 115: 1650
    PubMedGoogle Scholar
  • 26 Ross R. 1973. The smooth muscle cell in connective tissue metabolism and atherosclerosis. In: Kulo-MEN E. (ed.) Proceedings of the Sigrid Juselius Foundation Symposium in Turku, Finland London Academic Press; p 623
    Google Scholar
  • 27 Ross R, Glomset J. 1973; Atherosclerosis and the arterial smooth muscle cell. Proliferation of smooth muscle is a key event in the genesis of the lesions of atherosclerosis. Science (Wash D.C.) 180: 1332
    PubMedGoogle Scholar
  • 28 Ross R, Glomset J. 1976; The pathogenesis of atherosclerosis. New England Journal of Medicine, 295 369: 420
    PubMedGoogle Scholar
  • 29 Ross R, Harker L. 1976; Hyperlipidemia and atherosclerosis. Science 193: 1094
    CrossrefPubMedGoogle Scholar
  • 30 Ross R, Glomset J, Kariya B, Harker L. 1974; A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro. Proceedings of the National Academy of Sciences, U.S.A.. 71: 1207
    PubMedGoogle Scholar
  • 31 Rutherford RB, Ross R. 1976; Platelet factors stimulate fibroblasts and smooth muscle cells quiescent in plasma serum to proliferate. Journal of Cell Biology 69: 196
    CrossrefPubMedGoogle Scholar
  • 32 Stemerman MB, Ross R. 1972; Experimental arteriosclerosis. I. Fibrous plaque formation in primates, an electron microscope study. Journal of Experimental Medicine 136: 769
    CrossrefPubMedGoogle Scholar
  • 33 Virchow R. 1856. Phlogose und Thrombose im Gefäßsystem. Gesammelte Abhandlungen zur Wissenschaftlichen Medicin. Frankfurt: Meidinger Sohn and Co; p 458
    Google Scholar
  • 34 Wall RT. et al Human Endothelial Cell Migration. Laboratory Investigation, (in press)
    PubMedGoogle Scholar
  • 35 Wall RT, Harker LA, Striker GE, Quadracci LJ. 1977; Human endothelial cell injury mechanisms in vitro. Thrombosis and Haemostasis 38: 228
    PubMedGoogle Scholar
  • 36 Wall RT, Harker LA, Quadracci LJ, Striker GE. 1977; b Immune-mediated endothelial cell injury in the pathogenesis of thrombotic thrombocytopenic purpura (TTP). Clinical Research 25: #3-350 A
    PubMedGoogle Scholar
  • 37 Wall RT, Harker LA, Quadracci LJ, Striker GE. Factors influencing endothelial cell proliferation in vitro. Journal of Cell Physiol, (in press)
    PubMedGoogle Scholar
  • 38 Weiss HJ. 1972. The pharmacology of platelet inhibition. In: Spaet TH. (ed) Progress in Hemostasis and Thrombosis. Grune & Stratton; New York: 1 199
    Google Scholar
  • 39 Weiss HJ, Lages BA, Witte LD, Kaplan KL. Goodman De WS, Nossel HL, Baumgartner HR. 1977; Storage Pool Disease: Evidence for clinical and biochemical heterogeneity. Thrombosis and Haemostasis 38: 3
    PubMedGoogle Scholar
  • 40 Weiss HJ, Tschopp TB, Baumgartner HR. 1975; Impaired interaction (adhesionaggregation) of platelets with the subendothelium in storage-pool disease and after aspirin ingestion: A comparison with von Willebrand’s disease. New England Journal of Medicine 293: 619
    CrossrefPubMedGoogle Scholar
  • 41 Westermark B, Wasteson A. 1976; A platelet factor stimulating human normal glial cells. Experimental Cell Research 98: 170
    CrossrefPubMedGoogle Scholar
  • 42 Wight TN, Ross R. 1975; Proteoglycans in primate arteries. II. Synthesis and secretion of glycosaminoglycans by arterial smooth muscle cells in culture. Journal of Cell Biology 67: 675
    CrossrefPubMedGoogle Scholar