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Thromb Haemost 1989; 61(03): 468-473
DOI: 10.1055/s-0038-1646616
Original Article
Schattauer GmbH Stuttgart

Effect of a Moderate Fish Intake on Haemostatic Parameters in Healthy Males

A D Muller
1   The Department of Biochemistry, University of Limburg, Maastricht, The Netherlands
,
A C v Houwelingen
2   The Department of Human Biology, University of Limburg, Maastricht, The Netherlands
,
M C E van Dam-Mieras
1   The Department of Biochemistry, University of Limburg, Maastricht, The Netherlands
4   The Department of Natural Sciencesa, Open University of the Netherlands, Heerlen, The Netherlands,
,
B M Bas
3   The Department of Clinical Chemistry, Hospital “Maasland”, Sittard, The Netherlands
,
G Hornstra
1   The Department of Biochemistry, University of Limburg, Maastricht, The Netherlands
› Author Affiliations
Further Information

Publication History

Received 30 September 1988

Accepted after revision 30 January 1989

Publication Date:
24 July 2018 (online)

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Summary

This article describes the results of a dietary intervention study performed in three different centers. In the study the effect of a diet enriched with fish on the coagulation tendency of blood was investigated. Two groups of 40 volunteers were given a dietary supplement consisting of 135 g of canned mackerel or meat paste (control) for a 6 weeks period.

Compliance, monitored by measuring the urinary excretion of lithium, added to the supplements, was about 80%. Before, during and at the end of the experimental period a number of hemostatic parameters, reflecting the coagulation tendency of blood and the procoagulant activity of monocytes, were measured.

The fish supplement did not cause a significant effect on the prothrombin time and on the levels of factor VII, activated factor VII, antithrombin III, von Willebrand factor, fibrinogen, plasminogen and a2-antiplasmin. A slight but transient prolongation in the activated partial thromboplastin time was observed as well as a significant increase in the factor X level, which became more pronounced with prolongation of the experimental period; no activated factor X was found.

A tendency towards a stimulation of monocyte procoagulant activity was noticed.

Keywords

Fish - Diet - Compliance - Coagulation Factors - Monocytes - Procoagulant activity
 

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