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Thromb Haemost 1989; 61(03): 459-462
DOI: 10.1055/s-0038-1646614
Original Article
Schattauer GmbH Stuttgart

Plasminogen Activator Inhibitor 1: A New Prognostic Marker in Septic Shock

Gerard Pralong
1   The Hematology Laboratory, Department of Medicine, University Hospital, Lausanne, Switzerland
,
Thierry Calandra
1   The Hematology Laboratory, Department of Medicine, University Hospital, Lausanne, Switzerland
,
Michel-P Glausef
2   The Division of Infectious Diseases, Department of Medicine, University Hospital, Lausanne, Switzerland
,
Joop Schellekens
3   The Department of Infectious Diseases, University Hospital Utrecht, The Netherlands
,
Jan Verhoef
3   The Department of Infectious Diseases, University Hospital Utrecht, The Netherlands
,
Fedor Bachmann
1   The Hematology Laboratory, Department of Medicine, University Hospital, Lausanne, Switzerland
,
Egbert K O Kruithof
1   The Hematology Laboratory, Department of Medicine, University Hospital, Lausanne, Switzerland
› Author Affiliations
Further Information

Publication History

Received 11 November 1988

Accepted after revision 24 January 1989

Publication Date:
24 July 2018 (online)

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Summary

The prognostic value of plasminogen activator inhibitor type 1 (PAI-1) in septic shock was investigated in 52 patients with septic shock. The patients had significantly elevated serum PAI-1 levels with respect to the control group (p = 0.002). In patients not having a rapidly fatal underlying disease, PAI-1 was significantly higher in patients dying within a week after onset of shock than in survivors (median PAI-1: 900 and 307 ng/ml, respectively; p = 0.001). The analysis of the distribution of PAI-1 levels permitted retrospectively to determine a threshold level of PAI-1 which had prognostic significance. Mortality was 71% in patients with serum PAI-1 above 550 ng/ml, whereas only two patients (6%) having a PAI-1 below 550 ng/ml died within a week.

Thus, in patients with septic shock, PAI-1 appears to have a strong predictive value as to mortality. This early marker may help the clinician in identifying a subgroup of patients particularly at risk.

Keywords

Plasminogen activator inhibitor type 1 - Septicemia - Septic shock
 

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