Download PDF
Thromb Haemost 1995; 74(01): 282-290
DOI: 10.1055/s-0038-1642691
Symposium
Thrombosis Cancer
Schattauer GmbH Stuttgart

Role of Platelets, Thrombin, Integrin llb-llla, Fibronectin and Von Willebrand Factor on Tumor Adhesion in Vitro and Metastasis in Vivo

Mary Lynn Nierodzik
Department of Medicine, New York University Medicai Center, New York, NY, USA
,
Abraham Klepfish
Department of Medicine, New York University Medicai Center, New York, NY, USA
,
Simon Karpatkin
Department of Medicine, New York University Medicai Center, New York, NY, USA
› Author Affiliations
Further Information

Publication History

Publication Date:
09 July 2018 (online)

  PDF Download  Permissions and Reprints
 

  • References

  • 1 Gasic GJ, Gasic TB, Stewart CC. Antimetastatic effects associated with platelet reduction. Proc Natl Acad Sci 1968; 61: 46-52
    CrossrefPubMedGoogle Scholar
  • 2 Lemer WA, Pearlstein E, Ambrogio C. et al. A new mechanism for tumor- induced platelet aggregation: comparison with mechanisms shared by other tumors with possible pharmacologic strategy toward prevention of metastases. Int J Cancer 1983; 31: 463-469
    CrossrefPubMedGoogle Scholar
  • 3 Karpatkin S, earlstein E, Ambrogio C, Coller BS. Role of adhesive proteins in platelet tumor interaction in vitro and metatasis formation in vivo. J Clin Invest 1988; 81: 1012-1019
    CrossrefPubMedGoogle Scholar
  • 4 Pearlstein E, Ambrogio C, Karpatkin S. Effect of anti-platelet antibody on the development of pulmonary metastases following injection of CT26 colon adenocarcinoma, Lewis lung carcinoma and B16 amelanotic melanoma tumor cells into mice. Cancer Res 1984; 44: 3884-3887
    PubMedGoogle Scholar
  • 5 Nierodzik ML, Plotkin A, Kajumo F. et al. Thrombin stimulates tumor- platelet adhesion in vitro and metastasis in vivo. J Clin Invest 1991; 87: 229-236
    CrossrefPubMedGoogle Scholar
  • 6 Nierodzi kM L, Kajumo F, Karpatkin S. Effect of thrombin treatment of tumor cells on adhesion of tumor cells to platelets in vitro and tumor metastases in vivo. Cancer Res 1992; 52: 3267-3272
    PubMedGoogle Scholar
  • 7 Boukerche H, Berthier-Vergnes O, Tabone E. et al. Platelet melanoma cell interaction is mediated by the glycoprotein Ilb-IIIa complex. Blood 1989; 74: 658-663
    PubMedGoogle Scholar
  • 8 Cheresh DA, Spiro RC. Biosynthetic and functional properties of an arg- gly-asp-directed receptor involved in human melanoma cell attachment to vitronectin, fibrinogen and von Willebrand factor. J Biol Chem 1987; 262: 17703-17711
    PubMedGoogle Scholar
  • 9 Grossi IM, Hatfield JS, Fitzgerald LA. et al. Role of tumor cell glycoproteins immunologically related to glycoproteins lb and Ilb/IIIa in tumor cell-platelet and tumor cell-matrix interactions. FASEB J 1988; 2: 2385-2395
    CrossrefPubMedGoogle Scholar
  • 10 McGregor BC, McGregor JL, Weiss LM. Presence of cytoadhesions (Hb- Illa-like glycoproteins) on human metastatic melanomas but not on benign melanocytes. Am J Clin Pathol 1989; 92: 495-499
    CrossrefPubMedGoogle Scholar
  • 11 Klepfish A, Greco MA, Karpatkin S. Thrombin stimulates melanoma tumor-cell binding to endothelial cells and subendothelial matrix. Int J Cancer 1993; 53: 978-982
    CrossrefPubMedGoogle Scholar
  • 12 Rice GE, Bevilacqua MP. An inducible endothelial cell surface glycoprotein mediates melanoma adhesion. Science 1989; 246: 1303-1306
    CrossrefPubMedGoogle Scholar
  • 13 Zimmerman GA, McIntyre TM, Prescott SM. Thrombin stimulates the adherence of neutrophils to human endothelial cells in vitro. J Clin Invest 1985; 76: 2235-2246
    CrossrefPubMedGoogle Scholar
  • 14 Rasmussen UB, Couret-Cravieri V, Jallat S, Schlesinger Y, Pages G, Pavarini A, Lecocq JP, Pouyssegur J, Van Obberghen-Schilling E. cDNA cloning and expression of a hamster alpha-thrombin receptor coupled to CA++ mobilization. FEBS 1991; 288: 123-126
    CrossrefPubMedGoogle Scholar
  • 15 Vu TK, Hung DT, Wheaton VI, Coughlin SR. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 1991; 64: 1057-1068
    CrossrefPubMedGoogle Scholar
  • 16 Gerszten RE, Chen JI, Ishii M, Ishii K, Wang L, Nanevicz T, Turck C W, Vu T-KH, Coughlin SR. Specificity of the thrombin receptor for agonist peptide is defined by its extracellular surface. Nature 1994; 368: 648-648
    CrossrefPubMedGoogle Scholar
  • 17 Ngaiza JR, Jaffe EA. A 14 amino acid peptide derived from the amino terminus of the cleaved thrombin receptor elevates intracellular calcium and stimulates prostacyclin production in human endothelial cells. Biochem Biophys Res Commun 1991; 179: 1656-1661
    CrossrefPubMedGoogle Scholar
  • 18 Vassallo R R, Kieber-Emmons T, Cichowsky K, Brass LF. Structure- function relationships in the activation of platelet thrombin receptors by receptor-derived peptides. J Biol Chem 1992; 27: 6081-6085
    PubMedGoogle Scholar
  • 19 Zhong C, Hayzer DJ, Corson M, Runge MA. Molecular cloning of the rat smooth muscle thrombin receptor: evidence for in vitro regulation by basic fibroblast growth factor. J Biol Chem 1992; 267: 16975-16979
    PubMedGoogle Scholar
  • 20 Nierodzik ML, Bain M, Liu L-X, Shivji M, Karpatkin S. Presence of a second thrombin receptor on tumor cells. Blood 1994; 84 (Suppl. 01) 75a
    PubMedGoogle Scholar
  • 21 Chan B M, Matsuura N, Takada Y. In vitro and in vivo consequences of VLA-2 expression on Rhabdomyosarcoma cells. Science 1991; 251: 1600-1602
    CrossrefPubMedGoogle Scholar
  • 22 Iwamoto Y, Robey FA, Graf J. YIGSR a synthetic laminin pentapeptide inhibits experimental metastasis formation. Science 1987; 238: 1132-1134
    CrossrefPubMedGoogle Scholar
  • 23 Kramer R H, McDonald K A, Crowley E. et al. Melanoma cell adhesion to basement membrane mediated by integrin-related complexes. Cancer Res 1989; 49: 393-402
    PubMedGoogle Scholar
  • 24 Kramer R H, McDonald KA, Vu MP. Human melanoma cells express a novel integrin receptor for laminin. J Biol Chem 1989; 264: 15642-15649
    PubMedGoogle Scholar
  • 25 Soszka T, Knudsen KA, Beviglia L. et al. Inhibition of murine melanoma cell-matirx adhesion and experimental metastasis by Albolabrin, an RGD- containing peptide isolated from the venom ofTrimeresaras albolabris. Exp Cell Res 1991; 196: 6-12
    CrossrefPubMedGoogle Scholar
  • 26 Terranova VP, Williams JE, Liotta L. Modulation of metastatic activity of melanoma cells by laminin and fibronectin. Science 1984; 226: 982-984
    CrossrefPubMedGoogle Scholar
  • 27 Cheresh DA, Smith JW, Cooper HM. et al. A novel vitronectin receptor integrin (avbx) is responsible for distinct adhesive properties of carcinoma cells. Cell 1989; 57: 59-69
    CrossrefPubMedGoogle Scholar
  • 28 Kramer RH, Marks N. Identification of integrin collagen receptors on human melanoma cells. J Biol Chem 1989; 264: 4684-4688
    PubMedGoogle Scholar
  • 29 Castler V, Vara nJ, Fligiel S. et al. Anti-sense reduction in thrombospondin reverses the malignant phenotype of a human squamous carcinoma. J Clin Invest 1991; 87: 1883-1888
    CrossrefPubMedGoogle Scholar
  • 30 Roberts DD, Sherwood JA, Ginsburg V. Platelet thrombospondin mediates attachment and spreading of human melanoma cells. J Cell Biol 1987; 104: 131-139
    CrossrefPubMedGoogle Scholar
  • 31 Tuszynski GP, Gasic TB, Rothman VL. Thrombospondin, a potentiator of tumor cell metastasis. Cancer Res 1987; 47: 4130-4133
    PubMedGoogle Scholar
  • 32 Warren BA. The microinjuiy hypothesis and metastasis. In: Hemostatic Mechanisms and Metastasis Honn KV, Sloane BF, Nijhoff M. Boston: 1984 56.
    PubMedGoogle Scholar
  • 33 Boukerche H, Berthier-Vergues O, Bailly JF. A monoclonal antibody against the blood platelet glycoprotein Ilb/IIIa complex inhibits human melanoma growth in vivo. Blood 1989; 74: 909-912
    PubMedGoogle Scholar
  • 34 Humphries MJ, Olden K, Yamada KM. A synthetic peptide from fibronectin inhibits experimental metastases of murine melanoma cells. Science 1986; 467: 467-470
    PubMedGoogle Scholar
  • 35 Humphries MJ, Yamada KM, Olden K. Investigation of the biological effect of anti-cell adhesive synthetic peptides that inhibit experi-mental metastasis of B16-F10 murine melanoma cells. J Clin Invest 1988; 81: 782-790
    CrossrefPubMedGoogle Scholar
  • 36 Yoshida E, Verrusio EN, Mihara H, Oh D, Kwann HC. Enhancement of the expression of urokinase-type plasminogen activator from PC-3 human prostate cancer cells by thrombin. Cancer Res 1994; 54: 3300-3300
    PubMedGoogle Scholar
  • 37 Shankar R, de la M, Otte CA, Poptic EJ, ODicorleto PE. Thrombin receptoractivating peptides differentially stimulate platelet-derived growth factor production, monocytic cell adhesion, and E-selectin expression in human umbilical vein endothelial cells. J Biol Chem 1994; 269: 13936
    PubMedGoogle Scholar
  • 38 Colotta F, Sciacca FL, Sironi M, Luini W, Rabiet MJ, Mantovani A. Expression of monocyte chemotactic protein-1 by monocytes and endothelial cells exposed to thrombin. Am J Path 1994; 144: 975
    PubMedGoogle Scholar
  • 39 Grandaliano G, Valente Aj, OAbboud HE. A novel biologic activity of thrombin: stimulation of monocyte chemotactic protein production. J Exper Med 1994; 179: 1737
    CrossrefPubMedGoogle Scholar
  • 40 Glembotski CC, Irons CE, Krown KA, Murray SF, Sprenkle AB, Sei CA. Myocardial alpha-thrombin receptor activation induces hypertrophy and increases atrial natriuretic factor gene expression. J Biol Chem 1993; 268: 20646
    PubMedGoogle Scholar
  • 41 Bartha K, Brisson C, Archipoff G, De LaSalle C, Lanza F, Cazenave JP, Beretz A. Thrombin regulates tissue factor and thrombomodulin mRNA levels and activities in human saphenous vein endothelial cells by distinct mechanisms. J Biol Chem 1993; 268: 421-421
    PubMedGoogle Scholar
  • 42 Camey DH, Glenn KC, and uCnningham DD. Conditions which affect initiation of animal cell division by trypsin and thrombin. J Cell Physiol 1978; 95: 13-22
    CrossrefPubMedGoogle Scholar
  • 43 amey DH, Stiemberg J, and Fenton JW. Initiation of proliferative events by human a-thrombin requires both receptor binding and enzymic activity. J Cellular Biochem 1984; 26: 181-195
    CrossrefPubMedGoogle Scholar
  • 44 Chen LB, Buchanan JM. Mitogenic activity of blood components. I. Thrombin and prothrombin. Proc Natl Acad Sci USA 1975; 72: 131-135
    PubMedGoogle Scholar
  • 45 Glenn KC, Camey DH, Fenton JW. et al. Thrombin active site regions required for fibroblast receptor binding and initiation of cell division. J Biol Chem 1980; 255: 6609-6616
    PubMedGoogle Scholar
  • 46 Gospodarowicz D, Brown KD, Birdwell CR. et al Control of proliferation of human vascular endothelial cells.Characterization of the response of human umbilical vein endothelial cells to fibroblast growth factor, epidermal growth factor, and thrombin. J Cell Biol 1973; 77: 774-788
    PubMedGoogle Scholar
  • 47 Morris DL, Ward Jr JB, and Camey DH. Thrombin promotes cell transformation in Balb 3T3/A31-1-13 cells. Carcinogenesis (Lond.) 1992; 13: 67-73
    PubMedGoogle Scholar
  • 48 Lampugnani MG, Lolotta F, Polentamtti N. et al Thrombin induces c-fos expression in cultured human endothelial cells by a Ca++ dependent mechanism. Blood 1990; 76: 1173-1180
    PubMedGoogle Scholar
  • 49 Dom GW, Davis MG. Thrombin, but not thromboxane, stimulates megakaryocytic differentiation in human megakaryoblastic leukemia cells. J Pharmacol Exper Therapeutics 1992; 262: 1242-1247
    PubMedGoogle Scholar
  • 50 Greenberg AH, Egan SE, and Wright JA. Oncogenes and metastatic progression. Invasion Metastasis 1989; 9: 360-378
    PubMedGoogle Scholar
  • 51 Greig RG, Koestler TP, Trainer DC. et al Tumorigenic and metastatic properties of normal and ras-transfected NIH/3T3 cells. Proc Natl Acad Sci USA 1985; 82: 3698-3701
    CrossrefPubMedGoogle Scholar
  • 52 Thorgeirsson UP, Turpeenniemi-Hujanen T, Williams JE. et al NIH/3T3 cells transfected with human tumor DN A containing activated ras oncogenes express the metastatic phenotype in nude mice. Mol Cell Biol 1985; 5: 259-262
    CrossrefPubMedGoogle Scholar
  • 53 Rauscher FJ, Cohen DR, Curran T. et al fos-associated protein p39 is the product of the yw/t-oncogene. Science 1988; 240: 1010-1016
    CrossrefPubMedGoogle Scholar
  • 54 Laposata M, Dovnarsky DK, Shin HS. Thrombin-induced gap formation in confluent endothelial cell monolayers in vitro. Blood 1983; 62: 549-556
    PubMedGoogle Scholar
  • 55 Bastida E, Ordinas A, Escolar G. etal Tissue factor in microvesicles shed from U87 MG human glioblastoma cells induces coagulation, platelet aggregation and thrombogenesis. Blood 1984; 64: 177-184
    PubMedGoogle Scholar
  • 56 Dvorak HF, Van deWater L, Bitzer AM. et al Procoagulant activity associated with plasma membrane vesicles shed by cultured tumor cells. Cancer Res 1983; 43: 4334-4342
    PubMedGoogle Scholar
  • 57 Gordon SG, Cross BA. A factor X-activating cysteine protease from malignant tissue. J Clin Invest 1981; 67: 1665-1671
    CrossrefPubMedGoogle Scholar
  • 58 Honn KV, Sloane BF, Cavanaugh PG. Role of the coagulation system in tumor-cell-induced platelet aggregation and metastasis. Haemostasis 1988; 18: 37-46
    PubMedGoogle Scholar
  • 59 Kadish JL, Wenc KM, Dvorak HF. Tissue factor activity of normal and neoplastic cells: quantitation and species specificity. J Natl Cancer Inst 1983; 70: 551-557
    PubMedGoogle Scholar
  • 60 Pearlstein E, Ambrogio C, Gasic G. Inhibition of the platelet aggre-gating activity of two human adenocarcinomas of the colon and an anaplastic murine tumor with a specific thrombin inhibitor: Dansylarginine N-(3- ethyl-l,5-pentanediyl) amide. Cancer Res 1981; 41: 4535-4539
    PubMedGoogle Scholar
  • 61 Curatolo L, Colucci M, Cambini Al. et al Evidence that cells from experimental tumors can activate coagulation factor X. Br J Cancer 1979; 40: 228-233
    CrossrefPubMedGoogle Scholar
  • 62 Yoda Y, Abe T. Fibrinopeptide A (FPA) level and fibrinogen kinetics in patients with malignant disease. Thromb Haemostasis 1981; 46: 706-709
    Article in Thieme ConnectPubMedGoogle Scholar
  • 63 Merskey C, Johnson AJ, Harris JU. et al Isolation of fibrinogen -fibrin related antigen from human plasma by immune-affinity chromatography: its characterization in normal subjects and in defibrinating patients with abruptio placentae and disseminated cancer. Br J Haematol 1980; 44: 655-670
    CrossrefPubMedGoogle Scholar
  • 64 Peuscher FW, Cleton FJ, Armstrong L. et al. Significance of plasma fibrinopeptide A (FPA) in patients with malignancy. J Lab Clin Med 1980; 96: 5-14
    PubMedGoogle Scholar
  • 65 Rickies FR, Edwards RC, Barb C. et al. Abnormalities of blood coagulation in patients with cancer: fibrinopeptide A generation and tumor growth. Cancer 1983; 51: 301-307
    CrossrefPubMedGoogle Scholar
  • 66 Esumi N, Fan D, Fidler LJ. Inhibition of murine melanoma experimental metastasis by recombinant desulfatohirudin, a highly specific thrombin inhibitor. Cancer Res 1991; 51: 4549-4556
    PubMedGoogle Scholar
  • 67 Fidler IJ. Metastases: quantitative analysis of distribution and fate of tumor emboli labeled with 125I-5-iodo-2’-deoxyuridine. J Natl Cancer Inst 1970; 45: 773-782
    PubMedGoogle Scholar