Thromb Haemost 1995; 74(01): 117-122
DOI: 10.1055/s-0038-1642663
Symposium
Hemorheology
Schattauer GmbH Stuttgart

Flow-Related Platelet Deposition on Subendothelium

Harvey J Weiss
St. Luke’s-Roosevelt Hospital Center and the Columbia University College of Physicians and Surgeons, New York, NY, USA
› Author Affiliations
Further Information

Publication History

Publication Date:
09 July 2018 (online)

 
  • References

  • 1 Baumgartner HR. The role of blood flow in platelet adhesion, fibrin deposition and formation of mural thrombi. Microvasc Res 1973; 5: 167-179
  • 2 Sakariassen KS, Roald HE, Saslatti JA. Ex vivo models for studying thrombosis: Special emphasis on shear rate dependent blood-collagen interactions. In: Advances in Cardiovascular Engineering. Hwang NH C. ed. Plenum Press; New York, NY: 1992: 151-174
  • 3 Weiss HJ, Turitto VT, Baumgartner HR. Effect of shear rate on platelet interaction with subendothelium in citrated and native blood. Shear-dependent decrease of adhesion in von Willebrand’s disease and the Bemard-Soulier syndrome J Lab Clin Med 1978; 92: 750-764
  • 4 Turitto VT, Weiss HJ, Baumgartner HR. The effect of shear rate on platelet interaction with subendothelium exposed to citrated human blood. Microvasc Res 1980; 19: 352-365
  • 5 Turitto VT, Baumgartner HR. Platelet deposition on subendothelium exposed to flowing blood: Mathematical analysis of physical parameters. Trans Am Soc Artif Intern Organs 1975; 21: 593-601
  • 6 Turitto VT, Weiss HJ, Baumgartner HR. Rheological factors influencing platelet interaction with vessel surfaces. J Rheology 1979; 23: 735-749
  • 7 Turitto VT, Baumgartner HR. Platelet interaction with subendothelium in a perfusion system: Physical role of red blood cells. Microvas Res 1975; 9: 335-344
  • 8 Weiss HJ, Turitto VT, Baumgartner HR. Platelet adhesion and thrombus formation on subendothelium in platelets deficient in glycoproteins Ilb-IIIa, l b, and storage granules. Blood 1986; 67: 322-330
  • 9 Aarts PA M M, Steenduk P, Sixma JJ, Heethaar RM. Fluid shear as a possible mechanism for platelet diffusivity in flowing blood. J Biomech 1986; 19: 799-805
  • 10 Hellem AJ, Borchgrevink CF, Ames SB. The role of red cells in haemostasis: the relation between haematocrit, bleeding time and platelet adhesiveness. Brit J Haemat 1961; 7: 42-50
  • 11 Livio M, Gotti E, Marchesi D, Mecca G, Remuzzi G, de Gaetano G. Umemicbleeding: role of anaemia and beneficial effect of red cell transfusion. The Lancet 1982; 2: 1013-1016
  • 12 Fernandez F, Goudable C, Sie P, Ton-That H, Durand D, Sue JM, Boneu B. Low haematocrit and prolonged bleeding time in uraemic patients: effect of red cell transfusion. Brit J Haematol 1985; 59: 139-148
  • 13 Zwaginga JJ, IJsseldijk MJ W, de Groot PG, Kooistra M, Vos J, van Es A, Koomans H A, Struyvenberg A, Sixma JJ. Treatment of uremic anemia with recombinant erythropoietin also reduces the defects in platelet adhesion and aggregation caused by uremic plasma. Thromb Haemost 1991; 66: 638-647
  • 14 Goldsmith HL, Turitto VT. Rheological aspects of thrombosis and haemostasis: Basic principles and applications. Thromb Haemostas 1986; 55: 415-435
  • 15 Eckstein EC, Belgacem F. Model of platelet transport in flowing blood with drift and diffusion terms. Biophys J 1991; 60: 53-69
  • 16 Aarts PA M M, Bolhuis PA, Sakariassen KS, Heethaar RM, Sixma JJ. Red blood cell size is important for adherence of blood platelets to artery subendothelium. Blood 1983; 62: 214-217
  • 17 Aarts PA M M, Heethaar RM, Sixma JJ. Red blood cell deformability influences platelets - vessel wall interaction in flowing blood. Blood 1984; 64: 1228-1233
  • 18 van Breugel HH F I, de Groot PG, Heethaar RM, Sixma JJ. Role of plasma viscosity in platelet adhesion. Blood 1992; 80: 953-959
  • 19 Turitto VT, Weiss HJ. Red cells: Their dual role in thrombosis. Science 1980; 207: 541-543
  • 20 Reimers RC, Sutera SP, Joist JH. Potentiation by red blood cells of shear-induced platelet aggregation: relative importance of chemical and physical mechanisms. Blood 1984; 64: 1200-1206
  • 21 Santos MT, Valles J, Marcus AJ, Safier LB, Broekman MJ, Islan N, Ullman HL, Eiroa AM, Aznar J. Enhancement of platelet reactivity and modulation of eicosanoid production by intact erythrocytes. J Clin Invest 1991; 87: 571-580
  • 22 Valles J, Santos MT, Aznar J, Marcus AJ, Martinez-Sales V, Portoles M, Broekman MJ, Safier LB. Erythrocytes metabolically enhance collagen-induced platelet responsiveness via increased thromboxane production, adenosine diphosphate release, and recruitment. Blood 1991; 78: 154-162
  • 23 Weiss HJ, Baumgartner HR, Tschopp TB, Turitto VT, Cohen D. Correction by factor VIII of the impaired platelet adhesion to subendothelium in von Willebrand’s disease. Blood 1978; 51: 267-279
  • 24 Weiss HJ, Turitto VT, Baumgartner HR. Effect of shear rate on platelet interaction with subendothelium in citrated and native blood. Shear-dependent decrease of adhesion in von Willebrand’s disease and the Bemard-Soulier syndrome J Lab Clin Med 1978; 92: 750-764
  • 25 Sakariassen KS, Bolhuis PA, Sixma JJ. Human blood platelet adhesion to artery subendothelium is mediated by factor VIII: vWf bound to the subendothelium. Nature 1979; 279: 636-638
  • 26 Turitto VT, Weiss HJ, Zimmerman TS. Sussman II. Factor VHI/von Willebrand factor in subendothelium mediates platelet adhesion. Blood 1985; 65: 823-831
  • 27 Stel HV, Sakariassen KS, De Groot PG, van Mourik JA, Sixma JJ. Von Willebrand factor in the vessel wall mediates platelet adherence. Blood 1985; 65: 85-90
  • 28 Fressinaud E, Federici AB, Castaman G, Rothschild C, Rodeghiero F, Baumgartner HR, Mannucci PM, Meyer D. The role of platelet von Willebrand factor in platelet adhesion and thrombus formation: a study of 34 patients with various subtypes of type I von Willebrand’s disease. Br J Haemat 1994; 86: 327-332
  • 29 Castillo R, Escolar G, Monteaguda A, Ordinas M, Garrido M, Moia A, Federici AB, Mannucci PM. Role of platelet von Willebrand factor in supporting platelet-vessel wall interactions in von Willebrand’s disease. Am J Hematol 1989; 31: 153-158
  • 30 Weiss HJ. von Willebrand factor and platelet function. In: Progress in Vascular Biology, Hemostasis, and Thrombosis Ann NY Acad Sci 1991; 614: 125-139
  • 31 Turitto VT, Weiss HJ, Baumgartner HR. Platelet interaction with rabbit subendothelium in von Willebrand’s disease: altered thrombus formation distinct from defective platelet adhesion. J Clin Invest 1984; 74: 1730-1741
  • 32 Fressinaud E, Sakariassen KS, Rothschild C, Baumgartner HR, Meyer D. Shear rate-dependent impaiiment of thrombus growth on collagen in nonanticoagulated blood from patients with von Willebrand’s disease and hemophilia A. Blood 1992; 80: 988-994
  • 33 Baumgartner HR, Tschopp TB, Meyer D. Shear rate dependent inhibition of platelet adhesion and aggregation on collagenous surfaces by antibodies to human factor VHI/von Willebrand factor. Br J Haematol 1980; 44: 127-139
  • 34 Turitto VT. Physical factors influencing platelet deposition on subendothelium: Importance of blood shear rate. Ann NY Acad Sci 1977; 283: 284-292
  • 35 Peterson DM, Stathopoulos NA, Giorgio TD, Heliums JD, Moake JL. Shear-induced platelet aggregation requires von Willebrand factor and platelet membrane glycoproteins lb and Ilb-IIIa. Blood 1987; 69: 625-628
  • 36 Sakariassen KS, Nievelstein PF E M, Coller BS, Sixma JJ. The role of platelet membrane glycoproteins lb and Ilb-IIIa in platelet adherence to human artery subendothelium. Br J Haematol 1986; 63: 681-691
  • 37 Ruggeri ZM. Mechanisms of shear-induced platelet adhesion and aggregation. Thromb Haemost 1993; 70: 119-123
  • 38 Ruggeri ZM. Glycoprotein lb and von Willebrand factor in the process of thrombus formation. Ann NY Acad Sci 1994; 714: 200-210
  • 39 Ruggeri ZM. New insights into the mechanisms of platelet adhesion and aggregation. Sem Hema 1994; 31: 229-239
  • 40 Meyer D, Girina J-P. von Willebrand factor: Structure and function. Thromb Haemost 1993; 70: 99-104
  • 41 Ikeda Y, Handa M, Kawano K, Kamata T, Murata M, Araki Y, Anbo H, Kawai K, Watanable I, Itagaki K, Sakai F, Ruggeri ZM. The role of von Willebrand factor and fibrinogen in platelet aggregation under varying shear stress. J Clin Invest 1991; 87: 1234-1240
  • 42 Chow TW, Heliums JD, Moake JL, Kroll MH. Shear stress-induced von Willebrand factor binding to platelet glycoprotein lb initiates calcium influx associated with aggregation. Blood 1992; 80: 113-120
  • 43 Ikeda Y, Handa M, Kamata T, Kawano Y, Kawai K, Watanable K, Sakai F, Mayumi F, Itagaki I, Yoshioka A, Ruggeri ZM. Transmembrane calcium influx associated with von Willebrand factor binding to GPIb in the initiation of shear-induced platelet aggregation. Thromb Haemost 1993; 69: 496-502
  • 44 Weiss HJ, Turitto VT, Baumgartner HR. Platelet adhesion and thrombus formation on subendothelium in platelets deficient in glycoproteins Ilb-IIIa, l b, and storage granules. Blood 1986; 67: 322-330
  • 45 Turitto VT, Weiss HJ, Baumgartner HR. Decreased platelet adhesion on vessel segments in von Willebrand’s disease: a defect in initial platelet attachment. J Lab Clin Med 1983; 102: 551-564
  • 46 Weiss HJ, Turitto VT, Baumgartner HR. Further evidence that glycoprotein Ilb-IIIa mediates platelet spreading on subendothelium. Thromb Haemost 1991; 65: 202-205
  • 47 Cadroy TC, Hanson SR, Kelly AB, Marzec UM, Evatt BL, Kunicki TJ, Montgomery RR, Harker LA. Relative antithrombotic effects of monoclonal antibodies targeting different platelet glycoprotein-adhesive molecule interactions in nonhuman primates. Blood 1994; 83: 3218-3224
  • 48 Ruoslahti E. Integrins. J Clin Invest 1991; 87: 1-5
  • 49 Phillips DR, Charo IF, Parise LV, Fitzgerald LA. The platelet membrane glycoprotein GPIIb-IIIa complex. Blood 1988; 71: 831-843
  • 50 Weiss HJ, Hawiger J, Ruggeri ZM, Turitto VT, Thiagarajan P, Hoffmann T. Fibrinogen-independent interaction of platelets with subendothelium mediated by glycoprotein Ilb-IIIa complex at high shear rate. J Clin Invest 1989; 83: 288-297
  • 51 Fressinaud E, Baruch D, Girma J-P, Sakariassen KS, Baumgartner HR, Meyer D. von Willebrand factor-mediated platelet adhesion to collagen involves platelet membrane glycoprotein Ilb-IIIa as well as glycoprotein l b. J Lab Clin Med 1988; 112: 58-67
  • 52 Fressinaud E, Girma JP, Sadler JE, Baumgartner HR, Meyer D. Synthetic RGDS-containing peptides of von Willebrand factor inhibit platelet adhesion to collagen. Thromb Haemost 1990; 64: 589-593
  • 53 Weiss HJ, Hoffmann T, Yoshioka A, Ruggeri ZM. Evidence that the Arg 1744 Gly 1745 Asp 1746 sequence in the GPIIb-IIIa-binding domain of von Willebrand factor is involved in platelet adhesion and thrombus formation on subendothelium. J Lab Clin Med 1993; 122: 324-332
  • 54 Heynen HF G, Molero ML, de Groot PG, Nieuwenhuis K, Sixma JJ. Absence of ligands bound to glycoprotein Ilb-IIIa on the exposed surface of a thrombus may limit thrombus growth in flowing blood. J Clin Invest 1994; 94: 1098-1112
  • 55 Moon DG, Matayoshi BM, Weston LK, Minnear FL, Kaplan JE. Fibronectin inhibition of platelet thrombus formation in an in vivo porcine model of vascular injury. Thromb Res 1994; 76: 343-351
  • 56 Houdijk WP M, DeGroot PH G, Nievelstein PF E M, Sakariassen KS, Sixma JJ. Subendothelial proteins and platelet adhesion: von Willebrand factor and fibronectin, not thrombospondin, are involved in platelet adhesion to extracellular matrix of human vascular endothelial cells. Arteriosclerosis 1986; 6: 24-33
  • 57 Sixma JJ, de Groot PG. Regulation of platelet adhesion to the vessel wall. Ann NY Acad Sci 1994; 714: 190-199
  • 58 Beumer S, Ijsseldijk MJ W, de Groot PG, Sixma JJ. Platelet adhesion to fibronectin in flow: dependence on surface concentration and shear rate, role of platelet membrane glycoproteins GP Ilb/IIIa and VLA-5, and inhibition by heparin. Blood 1994; 84: 3724-3733
  • 59 Collins WE D, Mosher F, Tomasini BR, Cooper SL. A preliminary comparison of the thrombogenic activity of vitronectin and other RGD-containing proteins when bound to surfaces. Ann NY Acad Sci 1988; 516: 291-229
  • 60 Tschopp TB, Baumgartner HR. Defective platelet adhesion and aggregation on subendothelium exposed in vivo or in vitro to flowing blood of fawn-hooded rats with storage pool disease. Thromb Haemostas 1977; 38: 620-629
  • 61 Timmons S, Kloczewiak M, Hawiger H. ADP-dependent common receptor mechanisms for binding of von Willebrand factor and fibrinogen to human platelets. Proc Natl Acad Sci USA 1984; 81: 4935-4939
  • 62 Saelman EU M, Nieuwenhuis HK, Hese KM, de Groot PG, Heijnen HF G, Sage EH, Williams S, McKeown L, Gralnick HR, Sixma JJ. Platelet adhesion to collagen Types I through VIII under conditions of stasis and flow is mediated by GPIa/IIa (a2pj-integrin). Blood 1994; 83: 1244-1250
  • 63 Alveriadou R, Moake JL, Turner NA, Ruggeri ZM, Folie BJ, Phillips MD, Schreiber AB, Hrinda ME, Mclntire LV. Real-time analysis of shear-dependent thrombus formation and its blockade by inhibitors of von Willebrand factor binding to platelets. Blood 1993; 81: 1263-1276
  • 64 Tandon NN, Ockenhouse CF, Greco NJ, Jamieson GA. Adhesive functions of platelets lacking glycoprotein IV (CD36). Blood 1991; 78: 2809-2813
  • 65 Saelman EU M, Kehrel B, Hese KM, de Groot PG, Sixma JJ, Nieuwenhuis HK. Platelet adhesion to collagen and endothelial cell matrix under flow conditions is not dependent on platelet glycoprotein IV. Blood 1994; 83: 3240-3244
  • 66 Rand JH, Wu X-X, Potter BJ, Uson RR, Gordon RE. Co-localization of von Willebrand factor and Type VI collagen in human vascular subendothelium. Am J Pathol 1993; 142: 843-850
  • 67 Ross JM, Mclntire LV, Moake JL, Rand JH. Platelet adhesion and aggregation on human Type VI collagen surfaces under physiological flow conditions. Blood. in press
  • 68 Weiss HJ, Turitto VT, Baumgartner HR. The role of shear rate and platelets in promoting fibrin formation on rabbit subendothelium: studies utilizing patients with quantitative and qualitative platelet defects. J Clin Invest 1986; 78: 1072-1082
  • 69 Weiss HJ, Turitto VT, Baumgartner HR, Nemerson Y, Hoffmann T. Evidence for the presence of tissue factor on subendothelium. Blood 1989; 73: 968-975
  • 70 Weiss HJ, Hoffmann T, Turitto VT, Nemerson Y. Further studies on the presence of functional tissue activity on the subendothelium of normal human and rabbit arteries. Thromb Res 1994; 73: 313-326
  • 71 Inauen W, Baumgartner HR, Bombeli T, Haeberli A, Straub PW. Dose-and shear rate-dependent effects of heparin on thrombogenesis induced by rabbit aorta subendothelium exposed to flowing human blood. Arteriosclerosis 1990; 10: 607-615
  • 72 Hanson SR, Harker LA. Interruption of acute platelet-dependent thrombosis by the synthetic antithrombin D-phenylalanyl-L-prolyl-L-arginyl chloromethyl ketone. Proc Natl Acad Sci USA 1988; 85: 3184-3188
  • 73 Cadroy Y, Horbett TA, Hanson SR. Discrimination between platelet-mediated and coagulation mediated mechanisms in a model of complex thrombus formation in vivo. J Lab Clin Med 1989; 113: 436-448
  • 74 Badimon L, Badimon JJ, Lassila R, Hears M, Chesebro JH, Fuster V. Thrombin regulation of platelet interaction with damaged vessel wall and isolated collagen type I at arterial flow conditions in a porcine model: effects of hirudins, heparin, and calcium chelation. Blood 1991; 78: 423-434
  • 75 Gast A, Tschopp TB, Baumgartner HR. Thrombin plays a key role in late platelet thrombus growth and/or stability. Effect of a specific thrombin inhibitor on thrombogenesis induced by aortic subendothelium exposed to flowing rabbit blood Arterioscler Thromb 1994; 14: 1466-1474
  • 76 Pawashe AB, Golino P, Ambrosio G, Migliaccio F, Ragni M, Pascucci I, Chiariello M, Bach R, Game A, Konigsberg WK, Ezekowitz MD. A monoclonal antibody against rabbit tissue factor inhibits thrombus formation in stenotic injured rabbit carotid arteries. Circ Res 1994; 74: 56-63
  • 77 Coller BS, Folts JD, Scudder LE, Smith SR. Antithrombotic effect of a monoclonal antibody to the platelet glycoprotein Ilb/IIIa receptor in an experimental animal model. Blood 1986; 68: 783-786
  • 78 Eidt JF, Allison P, Noble S, Ashton J, Golino P, McNatt J, Buja LM, Willerson JT. Thrombin is an important mediator of platelet aggregation in stenosed canine coronary arteries with endothelial injury. J Clin Invest 1989; 84: 18-27