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Am J Perinatol 2018; 35(12): 1178-1185
DOI: 10.1055/s-0038-1642060
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Decreased Circulating Insulin-Like Growth Factor 1 Levels Are Associated with Cardiac Diastolic Dysfunction in Small for Gestational Age Infants

Yohei Akazawa
1   Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
,
Shoko Yamazaki
1   Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
,
Haruka Obinata
1   Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
,
Akira Hachiya
1   Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
,
Motoko Kamiya
1   Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
,
Noriko Motoki
1   Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
,
Tomohiko Nakamura
2   Division of Neonatology, Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
3   Division of Neonatology, Nagano Children's Hospital, Azumino, Nagano, Japan
› Author Affiliations
Further Information

Publication History

27 January 2018

13 March 2018

Publication Date:
24 April 2018 (online)

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Abstract

Objective To evaluate the impact of serum insulin-like growth factor-1 (IGF-1) levels on cardiac function in small for gestational age (SGA) infants.

Study Design This is a prospective, observational study. Serum IGF-1 levels at birth and echocardiography measurements at 1 week of age were compared between SGA and appropriate for gestational age (AGA) infants.

Results Thirty-one SGA infants and 27 AGA infants were enrolled. Serum IGF-1 levels were lower in the SGA infants than in the AGA infants. SGA infants had lower mitral lateral annular systolic (S') and early diastolic (E') tissue Doppler imaging velocities compared with AGA infants (S', 5.1 ± 0.9 vs 5.7 ± 1.2 cm/s; E', 6.1 ± 1.5 cm/s vs 7.1 ± 1.3 cm/s; p < 0.05). Serum IGF-1 levels positively correlated with E' velocity in the entire population (r = 0.44, p < 0.001) and in SGA infants (r = 0.39, p < 0.05). In multivariate linear regression analysis, serum IGF-1 and S' velocity were independently associated with E' velocity in the entire population and in SGA infants.

Conclusion Decreased serum IGF-I levels could account for cardiac diastolic dysfunction in SGA infants.

Keywords

fetal programming - intrauterine growth restriction - small for gestational age infant - insulin-like growth factor-1 - cardiac dysfunction - systolic–diastolic coupling
 

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