Some Computer Applications to Problems in Human Genetics^[*)]

Computer methods have been useful in the following applications in human genetics research (among many): 1) demonstration of what genes are on the same chromosome and the distance separating pairs of loci on the chromosome; 2) demonitration of sex differences in the recombination fraction; 3) assemblage of catalogs of rare recessive phenotypes in man; 4) maintenance of total genealogy of closed populations for such uses as a) determining common ancestor(s) of parents of persons with rare recessive disorders, and b) calculation of coefficients of consanguinity.

Der Einsatz von Computern hat sich im Rahmen der humangenetischen Forschung unter anderem auf folgenden Anwendungsgebieten als nützlich erwiesen: 1. Beim Nachweis der auf gleichen Chromosomen liegenden Gene und der Ermittlung der Entfernung der Genloci; 2. beim Nachweis von Geschlechtsdifferenzen in der Rekombinationshäufigkeit; 3. bei der Aufstellung von Katalogen über seltene rezessive Phänotypen beim Menschen; 4. bei der Erstellung von Stammbäumen in geschlossenen Populationen zum Zwecke des Nachweises gemeinsamer Vorfahren von Personen mit seltenen rezessiven Erbkrankheiten und zur Berechnung des Koeffizienten der Blutsverwandtschaft.

^* Paper presented to the 6th IBM Medical Symposium, Pough-keepsie and Brookhaven, N.Y., October 5-9, 1964.

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