Download PDF
Vet Comp Orthop Traumatol 1993; 06(02): 70-74
DOI: 10.1055/s-0038-1633022
Original Research
Schattauer GmbH

Relationship between Metallic Implants and Cancer: A Case-Control Study in a Canine Population

X. Q. Li
1   From Case Western Reserve University, Cleveland, Ohio, USA
,
D. L. Horn
1   From Case Western Reserve University, Cleveland, Ohio, USA
,
J. Black
1   From Case Western Reserve University, Cleveland, Ohio, USA
,
Sharon Stevenson
1   From Case Western Reserve University, Cleveland, Ohio, USA
› Author Affiliations
Further Information

Publication History

Received for publication 23 November 1992

Publication Date:
09 February 2018 (online)

    Permissions and Reprints

Summary

To assess the possible role of metallic implants in the development of local, systemic and remote site cancer, a case-controlled study was conducted in a canine population. The cases consisted of 222 dogs with tumours of any kind, preceded by a fracture and fixation between January 1979 and December 1990. The controls consisted of 1635 dogs who had fracture and fixation for fracture without a later development of tumour during the same time period, randomly selected from the same database. Age was found to be a strong positive predictor for the development of tumours. A significant protective effect on tumours other than bone and soft tissue tumour development was seen associated with internal fixation (P <0.05). There was not a significant increase of risk associated with metal materials for the development of bone and soft tissue tumours. Further study is needed to address the local effect of metallic implants on the development of bone and soft tissue tumours.

A case-control study was conducted to assess the relationship of metallic implants and the development of cancer in a canine population. No significant positive association was found between metal materials and the development of bone and soft tissue tumours.

Keywords

Fracture - metallic implants - cancer - case-control study - local and systemic effects
 

  • References

  • 1 Case Records of the Massachusetts General Hospital (Case 38-1965). N Engl J Med 1965; 273: 494-504.
    PubMedGoogle Scholar
  • 2 Arden GP, Bywaters EGL. Tissue reaction. In: Surgical Management of Juvenile Chronic Polyarthritis. Arden GP, Ansell BM. (eds). London: Academic Press; 1978: 269-70.
    Google Scholar
  • 3 Bago-Granell J, Aguirre-Canyadell M, Nardi J, Tallada N. Malignant fibrous histiocytoma of bone at the site of a total hip arthroplasty. A case report. J Bone Joint Surg [Br] 1984; 66-B: 38-40.
    CrossrefPubMedGoogle Scholar
  • 4 Penman HG, Ring PA. Osteosarcoma in association with total hip replacement. J Bone Joint Surg [Br] 1984; 66: 632-4.
    CrossrefPubMedGoogle Scholar
  • 5 Swann M. Malignant soft-tissue tumor at the site of a total hip replacement. J Bone Joint Surg [Br] 1984; 66: 629-31.
    PubMedGoogle Scholar
  • 6 Weber PC. Epithelioid sarcoma in association with total knee replacement: a case report. J Bone Joint Surg [Br] 1986; 68: 824-6.
    PubMedGoogle Scholar
  • 7 Ryu RK, Bovill Jr EG, Skinner HB, Murray WR. Soft tissue sarcoma associated with aluminium oxide ceramic total hip arthroplasty: a case report. Clin Orthop 1987; 216: 207-12.
    PubMedGoogle Scholar
  • 8 Lamovec J, Zidsar A, Cucek-Plenicar M. Synovial sarcoma associated with total hip replacement: a case report. J Bone Joint Surg [Am] 1988; 70: 1558-60.
    CrossrefPubMedGoogle Scholar
  • 9 Martin A, Bauer TW, Manlcy MT, Marks KE. Osteosarcoma at the site of total hip replacement: a case report. J Bone Joint Surg [Am] 1988; 70: 1561-7.
    CrossrefPubMedGoogle Scholar
  • 10 McDougall A. Malignant tumor at site of bone plating. J Bone Joint Surg [Br] 1956; 38: 709-13.
    PubMedGoogle Scholar
  • 11 Delgado ER. Sarcoma following a surgically treated fractured tibia. A case report. Clin Orthop 1958; 12: 315-8.
    PubMedGoogle Scholar
  • 12 Dube VE, Fisher DE. Hemangioendothelioma of the leg following metallic fixation of the tibia. Cancer 1972; 30: 1260-6.
    CrossrefPubMedGoogle Scholar
  • 13 Tayton KJJ. Ewing’s sarcoma at the site of a metal plate. Cancer 1980; 45: 413-5.
    CrossrefPubMedGoogle Scholar
  • 14 McDonald I. Malignant lymphoma associated with internal fixation of a fractured tibia. Cancer 1981; 48: 1009-11.
    CrossrefPubMedGoogle Scholar
  • 15 Dodion P, Putz P, Amiri-Lamraski MH. et al. Immunobiastic lymphoma at the site of an infected vitallium bone plate. Histopathology 1982; 6: 807-13.
    CrossrefPubMedGoogle Scholar
  • 16 Lee YS, Pho RWH, Nather A. Malignant fibrous histiocytoma at site of metal implant. Cancer 1984; 54: 2286-9.
    CrossrefPubMedGoogle Scholar
  • 17 Hughes AW, Sherlock DA, Hamblen DL, Reid R. Sarcoma at the site of a single hip screw. A case report. J Bone Joint Surg [Br] 1987; 69: 470-2.
    PubMedGoogle Scholar
  • 18 Case Records of the Massachusetts General Hospital (Case 4-1991). N Engl J Med 1991; 324: 251-9.
    CrossrefPubMedGoogle Scholar
  • 19 Gillespie WI, Frampton CMA, Henderson RJ, Ryan PM. The incidence of cancer following total hip replacement. J Bone Joint Surg [Br] 1988; 70: 539-42.
    PubMedGoogle Scholar
  • 20 Stevenson S, Hohn RB, Pohler OEM. et al. Fracture-associated sarcoma in the dog. J Am Vet Med Assoc 1982; 180: 1189-96.
    PubMedGoogle Scholar
  • 21 Stevenson S. Fracture-associated sarcomas. Vet Clin North Am Small Anim Pract 1991; 21: 859-72.
    CrossrefPubMedGoogle Scholar
  • 22 Schlesselman JJ. Case-control studies: Design, Conduct, Analysis. New York: Oxford University Press; 1982
    Google Scholar
  • 23 Brodey RS. The use of naturally occuring cancer in domestic animals for research into human cancer: general considerations and review of canine skeletal osteosarcoma. Yale J Biol Med 1979; 52: 345-61.
    PubMedGoogle Scholar
  • 24 Harvey CE, Newton CD, Schwartz A. Small Animal Surgery. Philadelphia: JB Lippincott Co; 1990: 570-85.
    Google Scholar
  • 25 Black J. Chemical and Foreign-body Carcinogenesis. Biological Performance of Materials 1981; 1: 128-47.
    PubMedGoogle Scholar