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Nuklearmedizin 1987; 26(02): 87-92
DOI: 10.1055/s-0038-1628869
Review Articles
Schattauer GmbH

Comparison of Quantification Methods of111In-Labelled Platelet Deposition in Peripheral Bypass Grafts

Vergleich der Quantifizierungsmethoden der In-markierten Plättchenabscheidung in peripheren Bypasstransplantaten
L. Mortelmans
*   From the Department of Nuclear Medicine, University of Leuven, Belgium
,
A. Verbruggen
*   From the Department of Nuclear Medicine, University of Leuven, Belgium
,
C. De Bakker
*   From the Department of Nuclear Medicine, University of Leuven, Belgium
,
A. Vandecruys
*   From the Department of Nuclear Medicine, University of Leuven, Belgium
,
J. Joosten
*   From the Department of Nuclear Medicine, University of Leuven, Belgium
,
A. Nevelsteen
**   From the University Hospital U. Z. Gasthuisberg, Leuven, the Department of Cardiovascular Surgery, University of Leuven, Belgium
,
L. Noyez
*   From the Department of Nuclear Medicine, University of Leuven, Belgium
,
M. Verstraete
***   From the University Hospital, U. Z. Gasthuisberg, Leuven, and the Centre for Thrombosis and Vascular Research, University of Leuven, Belgium
,
J. Vermylen
***   From the University Hospital, U. Z. Gasthuisberg, Leuven, and the Centre for Thrombosis and Vascular Research, University of Leuven, Belgium
,
M. De Roo
*   From the Department of Nuclear Medicine, University of Leuven, Belgium
› Author AffiliationsWe gratefully acknowledge the skillful secretarial work of Mrs. M. J. Vangoetsenhoven and the technical assistance to the measurements and calculations of Dr. J. De Groof.
Further Information

Publication History

Received: 08 October 1986

in revised form: 18 November 1986

Publication Date:
04 February 2018 (online)

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The action of antithrombotic drugs can be evaluated by measuring the deposition of111In-labelled platelets on peripheral bypass grafts several days after injection. This evaluation can be performed qualitatively (visual interpretation on the daily images) or quantitatively. Four different methods which calculate the ratio of platelet uptake with a reference region are compared: two methods use a gamma camera and two a detector. A blood sample or the region under the sternal angle are used as reference. The daily ratio of the counts, recorded by a gamma camera in a region of interest covering the graft, and the blood radioactivity interpolated from a platelet survival curve appears to be the most reliable method. The information of all the ratios can be combined in a single thrombogenicity index which reflects the daily rise of a linear or exponential regression versus time.

Zusammenfassung

Die Wirkung von Antithrombose-Medikamenten kann durch eine Messung der Ablagerung von mit 111In-markierten Blutplättchen auf periphere Bypassgrafts mehrere Tage nach der Injektion bewertet werden. Vier verschiedene Methoden zur Berechnung der relativen Ablagerung der Blutplättchen wurden verglichen: zwei Methoden benutzen eine Gammakamera, zwei einen Detektor. Die tägliche Speicherung, bestimmt aus einem Bereich um den Graft und der Blutradioaktivität, interpoliert mit einer Blutplättchen-Überlebenskurve, scheint die zuverlässigste Methode zu sein. Diese Relationen können in einem Thrombogenitätsindex zusammengefaßt werden, der den täglichen Zuwachs nach einer linearen oder exponentiellen Regression wiedergibt.

 

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