Nervenheilkunde 2006; 25(08): 623-625
DOI: 10.1055/s-0038-1626758
Originaler Artikel
Schattauer GmbH

Aktueller Stand zur TMS bei Depressionen

Current state concerning TMS in depression
U. Herwig
1   Abteilung Psychiatrie III, Universität Ulm (Ärztlicher Direktor Prof. Dr. Dr. M. Spitzer)
2   Psychiatrische Universitätsklinik Zürich, Klinik für Alterspsychiatrie (Direktor Prof. Dr. R. Nitsch)
,
C. Schönfeldt-Lecuona
1   Abteilung Psychiatrie III, Universität Ulm (Ärztlicher Direktor Prof. Dr. Dr. M. Spitzer)
› Author Affiliations
Further Information

Publication History

Publication Date:
18 January 2018 (online)

Zusammenfassung

Die transkranielle Magnetstimulation (TMS) gilt als eine mögliche neue Therapiemethode für Depressionen. In den letzten Jahren sind über 100 klinische Studien und Übersichtsarbeiten zu diesem Thema erschienen. Neuere Entwicklungen befassen sich mit der Erhaltungstherapie, mit der Augmentation von medikamentös antidepressiver Behandlung, mit dem Vergleich zur Elektrokonvulsionstherapie und mit der Stimulation bei älteren Patienten. Nichts desto trotz bleibt die Bedeutung der TMS für den klinischen Einsatz noch offen. Um diese Frage zu klären, laufen derzeit zwei Multizenterstudien, die sich vor dem Abschluss befinden.

Summary

Transcranial magnetic stimulation (TMS) offers to bea new treatment approach for depression. In the last years, more than a hundred clinical trials and reviews associated with this topic have been published. Newer issues are maintenance treatment, augmentation strategies for pharmacologic antidepressant treatment, comparison with electroconvulsion therapy, and the treatment in older patients. However, the impact of TMS for the clinical practice remains to be subject of debate. In order to clarify this question, two multicentric studies are currently performed and are expected to be finished soon.

 
  • Literatur

  • 1 Benadhira R, Saba G, Samaan A, Dumortier G, Lipski H, Gastal D. et al. Transcranial magnetic stimulation for refractory depression. Am J Psychiatry 2005; 162: 193.
  • 2 Fitzgerald PB, Brown TL, Marston NA, Daskalakis ZJ, De Castella A, Kulkarni J. Transcranial magnetic stimulation in the treatment of depression: a double-blind, placebo-controlled trial. Arch Gen Psychiatry 2003; 60: 1002-8.
  • 3 Fitzgerald P. Repetitive transcranial magnetic stimulation and electroconvulsive therapy: complementary or competitive therapeutic options in depression?. Australas Psychiatry 2004; 12: 234-8.
  • 4 Greenberg PE, Kessler RC, Birnbaum HG, Leong SA, Lowe SW, Berglund PA. et al. The economic burden of depression in the United States: how did it change between 1990 and 2000?. J Clin Psychiatry 2003; 64: 1465-75.
  • 5 Grunhaus L, Schreiber S, Dolberg OT, Polak D, Dannon PN. A randomized controlled comparison of electroconvulsive therapy and repetitive transcranial magnetic stimulation in severe and resistant nonpsychotic major depression. Biol Psychiatry 2003; 53: 324-31.
  • 6 Herwig U, Spitzer M, Schönfeldt-Lecuona C. Hat die antidepressive TMS klinische Bedeutung? Zur Notwendigkeit einer multizentrischen Studie. Nervenheilkunde 2003; 22: 196-9.
  • 7 Holtzheimer PE, Russo J, Claypoole KH, Roy-Byrne P, Avery DH. Shorter duration of depressive episode may predict response to repetitive transcranial magnetic stimulation. Depress Anxiety 2004; 19: 24-30.
  • 8 Li X, Nahas Z, Anderson B, Kozel FA, George MS. Can left prefrontal rTMS be used as a maintenance treatment for bipolar depression?. Depress Anxiety 2004; 20: 98-100.
  • 9 Lopez AD, Murray CC. The global burden of disease, 1990–2020. Nat Med 1998; 04: 1241-3.
  • 10 Miniussi C, Bonato C, Bignotti S, Gazzoli A, Gennarelli M, Pasqualetti P. et al. Repetitive transcranial magnetic stimulation (rTMS) at high and low frequency: an efficacious therapy for major drugresistant depression?. Clin Neurophysiol 2005; 116: 1062-71.
  • 11 Mosimann UP, Schmitt W, Greenberg BD, Kosel M, Muri RM, Berkhoff M. et al. Repetitive transcranial magnetic stimulation: a putative add-on treatment for major depression in elderly patients. Psychiatry Res 2004; 126: 123-33.
  • 12 Murray CJ, Lopez AD. Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. Lancet 1997; 349: 1436-42.
  • 13 Nahas Z, Li X, Kozel FA, Mirzki D, Memon M, Miller K. et al. Safety and benefits of distance-adjusted prefrontal transcranial magnetic stimulation in depressed patients 55-75 years of age: a pilot study. Depress Anxiety 2004; 19: 249-56.
  • 14 Pascual-Leone A, Rubio B, Pallardo F, Catala MD. Rapid-rate transcranial magnetic stimulation of left dorsolateral prefrontal cortex in drug-resistant depression. Lancet 1996; 348: 233-7.
  • 15 Poulet E, Brunelin J, Boeuve C, Lerond J, D’Amato T, Dalery J. et al. Repetitive transcranial magnetic stimulation does not potentiate antidepressant treatment. Eur Psychiatry 2004; 19: 382-3.
  • 16 Rumi DO, Gattaz WF, Rigonatti SP, Rosa MA, Fregni F, Rosa MO. et al. Transcranial magnetic stimulation accelerates the antidepressant effect of amitriptyline in severe depression: a doubleblind placebo-controlled study. Biol Psychiatry 2005; 57: 162-6.
  • 17 Stockinger G. Sanfte Keule. Der Spiegel. 53/1998..
  • 18 Su TP, Huang CC, Wei IH. Add-on rTMS for medication-resistant depression:a randomized, double-blind, sham-controlled trial in Chinese patients. J Clin Psychiatry 2005; 66: 930-7.