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Nuklearmedizin 1987; 26(01): 20-27
DOI: 10.1055/s-0038-1624356
Review Articles
Schattauer GmbH

On the Theory of the Measurement of the First-Pass Pulmonary Extraction Using the Indicator Dilution Technique

Syed Farooq Akber
1   From the UCLA School of Medicine, Los Angeles, California, USA, and the Institute of Medical Science, University of Toronto, Ontario, Canada
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Publication History

Publication Date:
04 February 2018 (online)

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Theory and concept of extraction involving invasive as well as non-invasive procedures to assess the first-pass extraction of tracers based on the indicator dilution technique are discussed. The experimental result of a noninvasive method using a gamma scintillation camera-computer system of firstpass pulmonary extraction of N-lsopropyl-123l-p-lodoamphetamine (123I-IMP) are also discussed.

Zusammenfassung

Theorie und Konzept der Bestimmung der first-pass Extraktion auf der Basis der Indikatorverdünnungsmethode werden sowohl für invasive als auch für nichtinvasive Verfahren diskutiert. Die First-pass Lungenextraktion von N-Isopropyl-123J-p-Jodamphetamin (123J-IMP) wird anhand experimenteller Daten mit einer Gammakamera und Rechner besprochen.

 

  • REFERENCES

  • 1 Akber S. F. A study of metabolic lung scanning with N-Isopropyl-123T-p-iodoamphetamine. 1982. Master Thesis, University of California; Los Angeles:
    Google Scholar
  • 2 Akber S. F. Ketamine influence on the first pass pulmonary extraction of N-isopropyl-123I-p-iodoamphetaminc using indicator dilution technique. Proc. XIV. Internat. Conf. on Med. and Biol. Engineer, and VII. Internat. Conf. on Med. Phys., Med. & Biol. Engineer, and Comput 1985; 23 Suppl., Part 2 1377-8.
    Google Scholar
  • 3 Akber S. F, Bennett L. R, Glass E. C. et al. Effeets of propranolol on the kinetics of N-isopropyl-123I-p-iodoamphetamine in the lung using multiple indicator dilution technique. Med. Phys 1984; 11: 742.
    Google Scholar
  • 4 Alderson P. O, Mendenhall K. H, Douglas K. G. et al. Deconvolution analysis in radionuclide quantitation of left to right cardiac shunts. J. nucl. Med 1979; 20: 502-6.
    PubMedGoogle Scholar
  • 5 Al-Ubiadi F, Bakhle Y. S. Metabolism of vasoactive hormones in human isolated lungs. Clin. Sei 1980; 58: 45-51.
    Google Scholar
  • 6 Anderson M. W, Orton T. C, Piekett R. D. et al. Accumulation of amines in the isolated perfused rabbit lung. J. Pharmae. exp. Ther 1974; 189: 456-66.
    Google Scholar
  • 7 Block E. R, Fisher A. B. Depression of serotonin clearance by rat lungs during oxygen exposure. J. appl. Physiol 1977; 42: 33-8.
    CrossrefPubMedGoogle Scholar
  • 8 Castelman K. R. Digital Image Processing. 139-89. Prentice Hall; Baltimore 1979:
    Google Scholar
  • 9 Chinard F. P, Enns T. Transcapillary pulmonary exchange of water in the dog. Amer. J. Physiol 1954; 178: 197-202.
    PubMedGoogle Scholar
  • 10 Connors A. F, McCaffree D. R, Rogers R. M. The ARDS. DM 1981; 27: 1-75.
    PubMedGoogle Scholar
  • 11 Crone C. The permeability of capillaries in various organs as determined by the use of the “indicator diffusion method”. Acta Physiol. Scand 1963; 58: 292-305.
    CrossrefPubMedGoogle Scholar
  • 12 Doria D. M. Analytical Laplace transforms and Fourier transform deconvolution of gamma variates. 1981. Master thesis in Medical Physics, University of California; Los Angeles:
    Google Scholar
  • 13 Fazio F, MacArthur T, Jones C. G. C.. et al. Measurement of required pulmonary edema in man using radioactive water (H2O15). Brit. J. Radiol 1976; 49: 393-7.
    CrossrefPubMedGoogle Scholar
  • 14 Fowler A. A, Baird M, Eberle N. et al. Attack-rates and mortality of the adult respiratory distress syndrome in patients with known predisposition abstracted. Ann. Rev. respir. Dis 1983; 125: 77.
    Google Scholar
  • 15 Fowler J. S, Gallagher B. M, MacGregor R. R. et al. Radiopharmaceuticals XIX: 11C labeled Octylamine: A potential diagnostic agent for lung structure and function. J. nucl. Med 1976; 17: 752-4.
    PubMedGoogle Scholar
  • 16 Gallagher B. M, Christman D, Fowler J. S. et al. Evaluation of radiorespirometry for the determination of MAO activity in vivo utilizing (C-11) octylamine as a substrate. Biochem. Pharmacol 1977; 26: 1917.
    CrossrefPubMedGoogle Scholar
  • 17 Gallagher B. M, Christman D, Fowler J. S. et al. Radioisotope scintigraphy for the study of dynamics of amine regulation by the human lung. Chest 1977; 71 (Suppl. 02) 282-4..
    CrossrefPubMedGoogle Scholar
  • 18 Gallagher B. M, Fowler J. S, MacGregor R. R. et al. In vivo measurement of transport and metabolic processes using radiotracers. In Principles of Radiopharmacology. 1979. Vol. II Columbetti C. 135-54. CRC Press; Florida:
    Google Scholar
  • 19 Gillis C. N, Catravas J. D. Altered removal of vasoactive substances in the injured lung: Detection of lung microvascular injury. Ann. N. Y. Acad. Sei 1982; 384: 458-74.
    CrossrefPubMedGoogle Scholar
  • 20 Gillis C. N, Cronau L. H, Mandel S. et al. Indicator dilution measurement of 5 HT clearance by human lung. J. appl. Physiol 1979; 46: 1178-83.
    CrossrefPubMedGoogle Scholar
  • 21 Glass E. C, Rahimian J, Touya J. J, Bennett L. R. Least squares quantitation of organ first pass studies. Proc. Third Symp. on Med. Appl. of Cyclotrons. 1983. Turku, Finland: June 6-9
    Google Scholar
  • 22 Guller B, Yipintsoi N, Orvis A. L. et al. Myocardial sodium extraction at varied coronary flows in the dog: Estimation of capillary permeability of residue and out flow detection. Circ. Res 1975; 37: 359-78.
    CrossrefPubMedGoogle Scholar
  • 23 Lassen N. A, Crone C. The extraction fraction of a capillary bed to hydrophilic molecules: Theoretical considerations regarding the single injection technique with a discussion of the role of diffusion between laminar streams (Taylor’s effect). In Capillary Permeability. 1970. Crone C, Lassen N. A. (eds.) 48-56. Academic Press; N.Y:
    Google Scholar
  • 24 Lassen N. A, Perl W. Tracer Kinetic Methods in Medical Physiology. 1979. Raven Press; New York:
    Google Scholar
  • 25 Rahimian J, Glass E. C, Touya J. J. et al. Measurement of metabolic extraction of tracers in the lung using multiple indicator dilution technique. J. nucl. Med 1984; 25: 31-7.
    PubMedGoogle Scholar
  • 26 Renkin E. M. Transport of potkssium-42 from blood to tissue in isolated mammalian skeletal muscles. Amer. J. Physiol 1959; 197: 1205-10.
    PubMedGoogle Scholar
  • 27 Syrota A, Pascal O, Crouzel M. et al. Pulmonary extraction of 11C chlorpromazine, measured by residue detection in man. J. nucl. Med 1981; 22: 145-8.
    PubMedGoogle Scholar
  • 28 Thompson H. K, Starmer E, Whalen R. E. et al. Indicator transit time considered as a gamma variate. Circ. Res 1964; 14: 502-15.
    CrossrefPubMedGoogle Scholar
  • 29 Williams D. L. Improvement in quantitative data analysis by numerical deconvolution analysis. J. nucl. Med 1979; 20: 568-70.
    PubMedGoogle Scholar
  • 30 Winchell H. S, Baldwin R. M, Lin T. H. Development of 123I labeled amines for brain studies: Localization of 123I iodophenylalkyl amines in rat brain. J. nucl. Med 1980; 21: 940-6. and Winchell, H. S., W. D. Horst, L. Braun et al.: N-isopropyl-123I-p-iodoamphetamine: Single pass brain uptake and wash out; binding to brain synaptosomes; and localization in dog and monkey brain.. J. nucl. Med. 1980; 21: 947-52
    PubMedGoogle Scholar
  • 31 Youdim M. B. H.. Inactivation of monoamines by the lung. In Metabolic Activities of the Lung. 1980: 105-28. Ciba Found. Symp. 78 N. S., Excerpta Medica; Amsterdam:
    Google Scholar