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Tierarztl Prax Ausg G Grosstiere Nutztiere 2013; 41(05): 315-324
DOI: 10.1055/s-0038-1623186
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Schattauer GmbH

Zur Bedeutung der Trockenperiode für die Entstehung und Vorbeugung von Neuinfektionen der bovinen Milchdrüse

Significance of the dry period for the development and prevention of new infections of the bovine mammary gland
J. Pieper
1   Mikrobiologie, Abteilung Bioverfahrenstechnik, Fakultät II, Hochschule Hannover
2   Klinik für Rinder, Tierärztliche Hochschule Hannover
,
M. Hoedemaker
2   Klinik für Rinder, Tierärztliche Hochschule Hannover
,
V. Krömker
1   Mikrobiologie, Abteilung Bioverfahrenstechnik, Fakultät II, Hochschule Hannover
› Author Affiliations
Further Information

Publication History

Eingegangen: 21 October 2012

Akzeptiert nach Revision: 15 May 2013

Publication Date:
08 January 2018 (online)

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Zusammenfassung

Die Trockenperiode birgt eine außerordentlich hohe Neuinfektionsgefahr für die bovine Milchdrüse, insbesondere durch umweltassoziierte Mastitiserreger. In der Regel ruft eine Infektion während der Trockenperiode keine klinischen Symptome hervor, führt aber oft nach dem Kalben, in den ersten Wochen der Laktation, zu einer klinischen Mastitis. Eine Reduzierung der Neuinfektionen trockenstehender Kühe kann die Mastitisinzidenz während der Frühlaktation deutlich verringern. Im Verlauf der Trockenperiode bleibt die Neuinfektionsrate nicht konstant, sondern ist unmittelbar nach dem Trockenstellen sowie kurz vor dem Kalben besonders hoch. Die Wahrscheinlichkeit einer Neuinfektion wird multifaktoriell durch Tier-, Erreger- und Umwelteinflüsse bestimmt. Eine wesentliche Rolle spielt hierbei der Verschluss des Zitzenkanals durch einen Keratinpfropf. Im Rahmen des antibiotischen Trockenstellens gibt es unterschiedliche Vorgehensweisen. Es können alle Euterviertel aller trockenzustellenden Kühe antibiotisch behandelt werden (generelles antibiotisches Trockenstellen, GAT) oder nur die Euterviertel der Kühe, in deren Milch Mastitiserreger oder erhöhte Zellgehalte nachgewiesen wurden (selektives antibiotisches Trockenstellen, SAT). Bei letzterer Variante muss weiterhin unterschieden werden, ob sich die Behandlung auf alle oder nur das von einer Infektion oder einem erhöhten Zellgehalt betroffene Euterviertel erstreckt. Anstelle des Einsatzes antibiotischer Wirkstoffe oder als Ergänzung dazu eignen sich Zitzenversiegler, die den Zitzenkanal nach außen hin abdichten und so die Funktion des Keratinpfropfes ergänzen oder übernehmen. Des Weiteren existieren einige alternative Vorgehensweisen zur Vermeidung von Neuinfektionen. Von übergeordneter Bedeutung ist allerdings die Minderung des Infektionsdrucks. Hierfür bestehen zahlreiche Möglichkeiten zur Verbesserung der Hygiene im Haltungsumfeld der Trockensteher.

Summary

The dry period poses an extraordinarily high risk of new infections for the bovine mammary gland. Environmental pathogens are of particular importance during this time. Normally, an infection during the dry period does not cause clinical symptoms, but is often responsible for clinical mastitis in the first weeks of lactation. Reducing new infections in dry cows can significantly decrease mastitis incidence in early lactation. During the course of the dry period, the new infection rate does not remain constant, but peaks immediately after drying off and shortly before calving. The chance of a new infection is influenced multifactorially by the animal, pathogen and environment. In this context, the closure of the teat canal using a keratin plug is very important. There are different approaches to antibiotic dry cow treatment. Either all udder quarters of all dry cows are treated (blanket dry-cow treatment) or just the udder of animals with a proven infection or an increased somatic cell count (selective dry-cow treatment). In the latter case, all udder quarters of an animal may be treated or just the one in which the infection or the increased somatic cell count was found. Instead of, or as a supplement to antibiotic treatment, teat sealers can be used. They support or take over the function of the keratin plug by closing the teat canal. In addition, there are some alternative methods to prevent new infections. Nevertheless, reducing the risk of infection is of primary importance. For this purpose, there are numerous options for improving hygiene in the environment of dry cows.

Schlüsselwörter

Eutergesundheit - Mastitis - Trockensteher - Antibiose - Neuinfektionsrate - Laktation

Key words

Udder health - mastitis - dry cow - antibiosis - new infection rate - lactation
 

  • Literatur

  • 1 Alber G. Lactoferrin. In: Lexikon der Veterinärmedizin. Wiesner E, Ribbeck R. Hrsg. Stuttgart: Enke; 2000: 832.
    Google Scholar
  • 2 Anderson NG, Côté JF. Dry cow therapy. Factsheet 90–003. Ontario Ministry of Agriculture, Food and Rural Affairs. 1996
    PubMedGoogle Scholar
  • 3 Berry EA. Recent evaluations of dry cow strategies. National Mastitis Council Annual Meeting Proceedings 2003; 31-41.
    PubMedGoogle Scholar
  • 4 Berry EA, Hillerton JE. The effect of an intramammary teat seal on new intramammary infections. J Dairy Sci 2002; 85: 2512-2520.
    CrossrefPubMedGoogle Scholar
  • 5 Berry EA, Hillerton JE. Effect of an intramammary teat seal and dry cow antibiotic in relation to dry period length on postpartum mastitis. J Dairy Sci 2007; 90: 760-765.
    CrossrefPubMedGoogle Scholar
  • 6 Berry SL, Maas J, Kirk JH, Reynolds JP, Gardner IA, Ahmadi A. Effects of antimicrobial treatment at the end of lactation on milk yield, somatic cell count, and incidence of clinical mastitis during the subsequent lactation in a dairy herd with a low prevalence of contagious mastitis. J Am Vet Med Assoc 1997; 211: 207-211.
    PubMedGoogle Scholar
  • 7 Bradley AJ. Bovine mastitis: an evolving disease. Vet J 2002; 164: 116-128.
    CrossrefPubMedGoogle Scholar
  • 8 Bradley AJ, Green MJ. A study of the incidence and significance of intramammary enterobacterial infections acquired during the dry period. J Dairy Sci 2000; 83: 1957-1965.
    CrossrefPubMedGoogle Scholar
  • 9 Bradley AJ, Green MJ. Aetiology of clinical mastitis in six Somerset dairy herds. Vet Rec 2001; 148: 683-686.
    CrossrefPubMedGoogle Scholar
  • 10 Bradley AJ, Green MJ. An investigation of the impact of intramammary antibiotic dry cow therapy on clinical coliform mastitis. J Dairy Sci 2001; 84: 1632-1639.
    CrossrefPubMedGoogle Scholar
  • 11 Bradley AJ, Green MJ. The importance of the nonlactating period in the epidemiology of intramammary infection and strategies for prevention. Vet Clin North Am Food Anim Pract 2004; 20: 547-68.
    CrossrefPubMedGoogle Scholar
  • 12 Bradley AJ, Green MJ. Dry Cow Therapy – An Update. Swedish Veterinary Conference 2007. www.qmms.co.uk/Data-QMMS/Documents/papers/DryCowTherapyAnUpdate.pdf (19.03.2013).
    PubMedGoogle Scholar
  • 13 Bradley AJ, Breen JE, Payne B, Green MJ. A comparison of broad-spectrum and narrow-spectrum dry cow therapy used alone and in combination with a teat sealant. J Dairy Sci 2011; 94: 692-704.
    CrossrefPubMedGoogle Scholar
  • 14 Burvenich C, Bannerman DD, Lippolis JD, Peelman L, Nonnecke BJ, Kehrli Jr ME, Paape MJ. Cumulative physiological events influence the inflammatory response of the bovine udder to Escherichia coli infections during the transition period. J Dairy Sci 2007; 90 (Suppl. 01) E39-54.
    CrossrefPubMedGoogle Scholar
  • 15 Bushe T, Oliver SP, Scannell RE. Changes in milk yield and composition following intermittent or abrupt milk cessation. J Dairy Sci 1984; 67 (Suppl. 01) 168-169.
    PubMedGoogle Scholar
  • 16 Capuco AV, Akers RM, Smith JJ. Mammary growth in Holstein cows during the dry period: quantification of nucleic acids and histology. J Dairy Sci 1997; 80: 477-487.
    CrossrefPubMedGoogle Scholar
  • 17 Capuco AV, Akers RM. Mammary involution in dairy animals. J Mammary Gland Biol Neoplasia 1999; 4: 137-144.
    CrossrefPubMedGoogle Scholar
  • 18 Church GT, Fox LK, Gaskins CT, Hancock DD, Gay JM. The effect of a shortened dry period on intramammary infections during the subsequent lactation. J Dairy Sci 2008; 91: 4219-4225.
    CrossrefPubMedGoogle Scholar
  • 19 Crispie F, Flynn J, Ross RP, Hill C, Meaney WJ. Dry cow therapy with a non-antibiotic intramammary teat seal – a review. Ir Vet J 2004; 57: 412-418.
    CrossrefPubMedGoogle Scholar
  • 20 Deutsche Veterinärmedizinische Gesellschaft (DVG), Fachgruppe „Milchhygiene“, Sachverständigenausschuss „Subklinische Mastitis“. Leitlinien Bekämpfung der Mastitis des Rindes als Bestandsproblem. Gießen: DVG; 2012
    Google Scholar
  • 21 Dingwell RT. Strategies for the prevention and elimination of intramammary infections in non-lactating dairy cows [DVSc], Guelph (Ontario): University of Guelph. Diss Abstr Int 2002; 63: 1738-B.
    PubMedGoogle Scholar
  • 22 Dingwell RT, Leslie KE, Schukken YH, Sargeant JM, Timms LL, Duffield TF, Keefe GP, Kelton DF, Lissemore KD, Conklin J. Association of cow and quarter-level factors at drying-off with new intramammary infections during the dry period. Prev Vet Med 2004; 63: 75-89.
    CrossrefPubMedGoogle Scholar
  • 23 Eberhart RJ. Management of dry cows to reduce mastitis. J Dairy Sci 1986; 69: 1721-1732.
    CrossrefPubMedGoogle Scholar
  • 24 Erskine RJ, Bartlett PC, Tavernier SR, Fowler LH, Walker RD, Seguin JH, Shuster D. Recombinant bovine interleukin-2 and dry cow therapy: efficacy to cure and prevent intramammary infections, safety, and effect on gestation. J Dairy Sci 1998; 81: 107-115.
    CrossrefPubMedGoogle Scholar
  • 25 Farnsworth RJ, Wyman L, Hawkinson R. Use of a teat sealer for prevention of intramammary infections in lactating cows. J Am Vet Med Assoc 1980; 177: 441-444.
    PubMedGoogle Scholar
  • 26 Godden S, Rapnicki P, Stewart S, Fetrow J, Johnson A, Bey R, Farnsworth R. Effectiveness of an internal teat seal in the prevention of new intramammary infections during the dry and early-lactation periods in dairy cows when used with a dry cow intramammary antibiotic. J Dairy Sci 2003; 86: 3899-3911.
    CrossrefPubMedGoogle Scholar
  • 27 Green MJ, Green LE, Medley GF, Schukken YH, Bradley AJ. Influence of dry period bacterial intramammary infection on clinical mastitis in dairy cows. J Dairy Sci 2002; 85: 2589-2599.
    CrossrefPubMedGoogle Scholar
  • 28 Green MJ, Bradley AJ, Medley GF, Browne WJ. Cow, farm, and management factors during the dry period that determine the rate of clinical mastitis after calving. J Dairy Sci 2007; 90: 3764-76.
    CrossrefPubMedGoogle Scholar
  • 29 Green M, Huxley J, Madouasse A, Browne W, Medley G, Bradley A, Biggs A, Breen J, Burnell M, Hayton A, Husband J, Reader J, Statham J, Thorne M. Making good decisions on dry cow management to improve udder health – Synthesising evidence in a Bayesian framework. Cattle Pract 2008; 16: 200-208.
    PubMedGoogle Scholar
  • 30 Halasa T, Østerås O, Hogeveen H, van Werven T, Nielen M. Meta-analysis of dry cow management for dairy cattle. Part 1. Protection against new intramammary infections. J Dairy Sci 2009; 92: 3134-3149.
    CrossrefPubMedGoogle Scholar
  • 31 Halasa T, Nielen M, Whist AC, Østerås O. Meta-analysis of dry cow management for dairy cattle. Part 2. Cure of existing intramammary infections. J Dairy Sci 2009; 92: 3150-3157.
    CrossrefPubMedGoogle Scholar
  • 32 Hogan JS, Pankey JW, Duthie AH. Growth inhibition of mastitis pathogens by long-chain fatty acids. J Dairy Sci 1987; 70: 927-934.
    CrossrefPubMedGoogle Scholar
  • 33 Huijps K, Hogeveen H. Stochastic modeling to determine the economic effects of blanket, selective, and no dry cow therapy. J Dairy Sci 2007; 90: 1225-1234.
    CrossrefPubMedGoogle Scholar
  • 34 Huxley JN, Green MJ, Green LE, Bradley AJ. Evaluation of the efficacy of an internal teat sealer during the dry period. J Dairy Sci 2002; 85: 551-561.
    CrossrefPubMedGoogle Scholar
  • 35 International Dairy Federation (IDF). 2011 Suggested interpretation of mastitis terminology. IDF-Bulletin No 448..
    PubMedGoogle Scholar
  • 36 Jensen DL, Eberhart RJ. Total and differential cell counts in secretions of the non-lactating bovine mammary gland. Am J Vet Res 1981; 42: 743-747.
    PubMedGoogle Scholar
  • 37 Krömker V. Zum Trockenstellen unter antibiotischem Schutz. In: Tagung der Fachgruppe „Milchhygiene“, Arbeitskreis „Eutergesundheit“ der Deutschen Veterinärmedizinischen Gesellschaft e.V. Hannover, 27.–28.05.1999. Deutsche Veterinärmedizinische Gesellschaft. Hrsg., Gießen: DVG; 1999: 118-128.
    Google Scholar
  • 38 Krömker V. Ökonomie der Mastitis. In: Kurzes Lehrbuch Milchkunde und Milchhygiene. Krömker V. Hrsg. Stuttgart: Parey; 2007: 49-50.
    Google Scholar
  • 39 Krömker V, Pfannenschmidt F, Friedrich J. Neuinfektionsrate der Milchdrüsen von Milchkühen in der Trockenperiode nach Anwendung eines internen Zitzenversieglers zum Trockenstellen. Berl Münch Tierärztl Wochenschr 2010; 123: 215-220.
    PubMedGoogle Scholar
  • 40 Lacasse P, Lauzon K, Diarra MS, Petitclerc D. Utilization of lactoferrin to fight antibiotic-resistant mammary gland pathogens. J Anim Sci 2008; 86 (Suppl. 13) 66-71.
    CrossrefPubMedGoogle Scholar
  • 41 Leslie K. Mastitis prevention strategies for the dry period. National Mastitis Council Regional Meeting Proceedings 1999; 35.
    PubMedGoogle Scholar
  • 42 Lim GH, Leslie KE, Kelton DF, Duffield TF, Timms LL, Dingwell RT. Adherence and efficacy of an external teat sealant to prevent new intramammary infections in the dry period. J Dairy Sci 2007; 90: 1289-1300.
    CrossrefPubMedGoogle Scholar
  • 43 Mansfeld R, Sauter-Louis C, Martin R. Auswirkungen der Länge der Trocken stehzeit bei Milchkühen auf Leistung, Gesundheit, Fruchtbarkeit und Kolostrumqualität. Tierärztl Prax Nutztiere 2012; 40 (G) 239-250.
    PubMedGoogle Scholar
  • 44 Martin G, Schafberg R, Swalve HH. Udder health data in dairy cattle breeding: An alternative approach for genetic evaluation. 9th World Congress on Genetics Applied to Livestock Production, Leipzig 01.–06.08.2010. www.kongressband.de/wcgalp2010/assets/pdf/0406.pdf (19.03.2013).
    PubMedGoogle Scholar
  • 45 McDonald JS, Anderson AJ. Experimental intramammary infection of the dairy cow with Escherichia coli during the nonlactating period. Am J Vet Res 1981; 42: 229-231.
    PubMedGoogle Scholar
  • 46 Meaney WJ. Effect of a dry period teat seal on bovine udder infection. Ir J Agric Res 1977; 16: 293-299.
    PubMedGoogle Scholar
  • 47 Morimoto K, Shimizu M, Kurose T, Nakatani K, Akita S, Shinozuka Y, Isobe N. Efficacy of enterotoxigenic Escherichia coli vaccine for bovine clinical mastitis. J Dairy Res 2011; 78: 149-153.
    CrossrefPubMedGoogle Scholar
  • 48 National Mastitis Council (NMC). A practical look at environmental mastitis. 1997 www.nmconline.org/environmental.htm (14.03.2013).
    PubMedGoogle Scholar
  • 49 National Mastitis Council (NMC). NMC Factsheet – Dry Cow Therapy. National Mastitis Council. 2006 http://www.nmconline.org/drycow.htm 23.09.2012.
    PubMedGoogle Scholar
  • 50 Natzke RP. Elements of mastitis control. J Dairy Sci 1981; 64: 1431-1442.
    CrossrefPubMedGoogle Scholar
  • 51 Neave FK, Dodd FH, Henriques E. Udder infections in the ’dry period’. J Dairy Res 1950; 17: 37-49.
    CrossrefPubMedGoogle Scholar
  • 52 Oliver SP, Smith KL. Nonantibiotic approach in control of bovine mastitis during dry period. J Dairy Sci 1982; 65: 2119-2124.
    CrossrefPubMedGoogle Scholar
  • 53 Oliver SP, Bushe T. Growth inhibition of Escherichia coli and Klebsiella pneumoniae during involution of the bovine mammary gland: Relation to secretion composition. Am J Vet Res 1987; 48: 1669-1673.
    PubMedGoogle Scholar
  • 54 Ollier S, Zhao X, Lacasse P. Effect of prolactin-release inhibition on milk production and mammary gland involution at drying-off in cows. J Dairy Sci 2013; 96: 335-343.
    CrossrefPubMedGoogle Scholar
  • 55 O‘Rourke D. Assessment of cows for use of a nonantimicrobial dry cow product. J Appl Microbiol 2005; 98: 1256-1260.
    CrossrefPubMedGoogle Scholar
  • 56 Østerås O. Results of dry cow therapy on udder health and production. Proc. II of 3. Int. Mastitis Seminar 1995, Tel Aviv, Israel 49-53.
    PubMedGoogle Scholar
  • 57 Robert A, Seegers H, Bareille N. Incidence of intramammary infections during the dry period without or with antibiotic treatment in dairy cows – a quantitative analysis of published data. Vet Res 2006; 37: 25-48.
    CrossrefPubMedGoogle Scholar
  • 58 Robert A, Roussel P, Bareille N, Ribaud D, Sérieys F, Heuchel V, Seegers H. Risk factors for new intramammary infections during the dry period in untreated cows from herds using selective dry cow therapy. Animal 2008; 2: 247-254.
    CrossrefPubMedGoogle Scholar
  • 59 Ryan MP, Meaney WJ, Ross RP, Hill C. Evaluation of lacticin 3147 and a teat seal containing this bacteriocin for inhibition of mastitis pathogens. Appl Environ Microbiol 1998; 64: 2287-2290.
    PubMedGoogle Scholar
  • 60 Ryan MP, Flynn J, Hill C, Ross RP, Meaney WJ. The natural food grade inhibitor, lacticin 3147, reduced the incidence of mastitis after experimental challenge with Streptococcus dysgalactiae in nonlactating dairy cows. J Dai ry Sci 1999; 82: 2625-2631.
    PubMedGoogle Scholar
  • 61 Schultze WD. Control of new intramammary infection at calving by prepartum teat dipping. J Dairy Sci 1985; 68: 2094-2099.
    CrossrefPubMedGoogle Scholar
  • 62 Seegers H, Fourichon C, Beaudeau F. Production effects related to mastitis and mastitis economics in dairy cattle herds. Vet Res 2003; 34: 475-491.
    CrossrefPubMedGoogle Scholar
  • 63 Smith KL, Oliver SP. Lactoferrin: a component of nonspecific defense of the involuting bovine mammary gland. Adv Exp Med Biol 1981; 137: 535-554.
    PubMedGoogle Scholar
  • 64 Smith KL, Todhunter DA, Schoenberger PS. Environmental pathogens and intramammary infection during the dry period. J Dairy Sci 1985; 68: 402-417.
    CrossrefPubMedGoogle Scholar
  • 65 Smith KL, Todhunter DA, Schoenberger PS. Environmental mastitis: cause, prevalence, prevention. J Dairy Sci 1985; 68: 1531-1553.
    CrossrefPubMedGoogle Scholar
  • 66 Smith KL, Hogan JS. Environmental mastitis. Vet Clin North Am Food Anim Pract 1993; 9: 489-498.
    CrossrefPubMedGoogle Scholar
  • 67 Sordillo LM, Shafer-Weaver K, DeRosa D. Immunobiology of the mammary gland. J Dairy Sci 1997; 80: 1851-1865.
    CrossrefPubMedGoogle Scholar
  • 68 Timms L. Field trial evaluations of a novel persistent barrier teat dip for preventing mastitis during the dry period and as a potential substitute for dry cow antibiotic therapy. National Mastitis Council Annual Meeting Proceedings 2001; 262-263.
    PubMedGoogle Scholar
  • 69 Todhunter DA, Smith KL, Hogan JS, Schoenberger PS. Gram-negative bacterial infections of the mammary gland in cows. Am J Vet Res 1991; 52: 184-188.
    PubMedGoogle Scholar
  • 70 Williamson JH, Woolford MW, Day AM. The prophylactic effect of a drycow antibiotic against Streptococcus uberis. N Z Vet J 1995; 43: 228-234.
    CrossrefPubMedGoogle Scholar
  • 71 Woolford MW, Williamson JH, Day AM, Copeman PJ. The prophylactic effect of a teat sealer on bovine mastitis during the dry period and the following lactation. N Z Vet J 1998; 46: 12-19.
    CrossrefPubMedGoogle Scholar