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Tierarztl Prax Ausg G Grosstiere Nutztiere 2013; 41(01): 61-66
DOI: 10.1055/s-0038-1623152
Case Report
Schattauer GmbH

Lameness in weaned pigs associated with tetracycline overdose

Lahmheiten bei Absetzferkeln assoziiert mit einer Tetrazyklin-Überdosierung
V. Gotter
1   University of Veterinary Medicine Hannover, Field Station for Epidemiology, Bakum, Germany
,
P. Wolf
2   University of Veterinary Medicine Hannover, Institute of Animal Nutrition, Hannover, Germany
,
J. Kamphues
2   University of Veterinary Medicine Hannover, Institute of Animal Nutrition, Hannover, Germany
,
E. Grosse Beilage
1   University of Veterinary Medicine Hannover, Field Station for Epidemiology, Bakum, Germany
› Author Affiliations
Further Information

Publication History

Received: 20 February 2012

Accepted after revision: 10 October 2012

Publication Date:
05 January 2018 (online)

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Summary

On a piglet producing farm severe lameness was observed in pigs which had been weaned 3 weeks and longer due to severe distortions of joints and claws of fore and/or hind legs. Splaying of claws as well as flexural limb deformations particularly in the carpal joints increased in degree the older and heavier the pigs were. Because of coughing in the weaners, which had started 7–8 weeks before any lameness or limb deformation had been apparent, tetracycline was applied via water as medication. During the course of an on-site investigation, a miscalculation of dosage – 129–168 mg tetracycline per kg body weight – was revealed. It was therefore suggested to the farmer and his veterinarian to immediately stop the application of tetracycline and to use a different antibiotic against the still present coughing and sneezing. During a follow-up evaluation 4 weeks later, the farmer reported a significant decrease in affected animals. While a direct correlation between the lameness in the weaned pigs and the tetracycline dosage could not be proven, the existing evidence supports the theory that the overdosage was at least a contributing factor.

Zusammenfassung

In einem Ferkelerzeugerbestand wurden bei Ferkeln ab 3 Wochen nach dem Absetzen zunehmend hochgradige Lahmheiten bedingt durch schwere Distorsionen der Gelenke und Klauen an den Vorder- und/ oder Hintergliedmaßen beobachtet. Das Spreizen der Klauen und die Durchbiegigkeit in den Gelenken der Gliedmaßen, besonders der Karpalgelenke, nahm mit dem Alter zu. Aufgrund von Husten, der 8 Wochen vor dem Auftreten erster Lahmheiten festgestellt wurde, bekamen alle Ferkel Tetracyclin über das Trinkwasser verabreicht. Während der Bestandsuntersuchung wurde eine Fehlkalkulation der Dosierung festgestellt: 129–168 mg Tetracyclin pro Kilogramm Körpergewicht. Dem Tierhalter und Tierarzt wurde empfohlen, die Anwendung von Tetracyclin umgehend zu beenden und stattdessen einen anderen Wirkstoff gegen die immer noch auftretenden Atemwegserkrankungen einzusetzen. Bei einer Nachuntersuchung 4 Wochen später wurde ein signifikanter Rückgang der Lahmheiten beobachtet. Obwohl die Kausalität zwischen Tetracyclin und den Lahmheiten nicht eindeutig nachzuweisen war, liegen doch Hinweise für eine ursächliche Beteiligung der Überdosierung an der Entstehung der Symptome vor.

Key words

Swine - medication - water supply - non-infectious - multi-factorial disease

Schlüsselwörter

Schwein - Medikamente - Wasserversorgung - nichtinfektiös - multifaktorielle Erkrankung

 

  • References

  • 1 Arnoczky SP, Lavagnino M, Gardner KL, Tian T, Vaupel ZM, Stick JA. In vitro effects of oxytetracycline on matrix metalloproteinase-1 mRNA expression and on collagen gel contraction by cultured myofibroblasts obtained from the accessory ligament of foals. Am J Vet Res 2004; 65: 491-496.
    CrossrefPubMedGoogle Scholar
  • 2 Auer J. Diagnosis and treatment of flexural deformities in foals. Clin Tech Equine Pract 2006; 4: 282-295.
    PubMedGoogle Scholar
  • 3 Beineke A, Bennecke K, Neis C, Schröder C, Waldmann KH, Baumgärtner W. Comparative evaluation of virulence and pathology of Streptococcus suis serotypes 2 and 9 in experimentally infected growers. Vet Micro 2008; 128: 423-430.
    CrossrefPubMedGoogle Scholar
  • 4 Bereskin B. Genetic aspects of feet and leg soundness in Swine. J Anim Sci 1979; 48: 1322-1328.
    CrossrefPubMedGoogle Scholar
  • 5 Blair R, Aherne FX, Doige CE. Tolerance of growing pigs for dietary vitamin A, with special reference to bone integrity. Int J Vitam Nutr Res 62: 130-133.
    PubMedGoogle Scholar
  • 6 Brihoum M, Amory H, Desmecht D, Cassart D, Deleuze S, Rollin F. Descriptive study of 32 cases of doxycycline-overdosed calves. J Vet Intern Med 2010; 5: 1203-1210.
    PubMedGoogle Scholar
  • 7 Brihoum M, Rollin F, Desmecht D, Detilleux J, Amory H. Clinical evaluation of cardiac effects of experimental doxycycline overdosing in healthy calves. BMC Vet Res 2011; 7: 40.
    CrossrefPubMedGoogle Scholar
  • 8 Busch ME, Wachmann H. Osteochondrosis of the elbow joint in finishing pigs from three herds: associations among different types of joint changes and between osteochondrosis and growth rate. Vet J 2011; 188: 197-203.
    CrossrefPubMedGoogle Scholar
  • 9 Canham PA. An outbreak of lameness in growing pigs. The Pig Journal 1998; 42: 141-143.
    PubMedGoogle Scholar
  • 10 Caswell AH, Hutchison DJ. Selectivity of cation chelation to tetracyclines: Evidence for special conformation of calcium chelate. Biochem Biophys Res Commun 1971; 43: 625-630.
    CrossrefPubMedGoogle Scholar
  • 11 Chopra I, Hawkey PM, Hinton M. Tetracycline: molecular and clinical aspects. J Antimicrob Chemother 1992; 29: 245-277.
    CrossrefPubMedGoogle Scholar
  • 12 Dewey CE. Diseases of the nervous and locomotor systems. In: Diseases of Swine. Straw BE, D’Allaire S, Mengeling WL, Taylor DJ. eds. Ames: Blackwell; 2006: 861-882.
    Google Scholar
  • 13 Frey HH, Löscher W. In Lehrbuch der Pharmakologie und Toxikologie für die Veterinärmedizin. Frey HH, Löscher W. Hrsg. Stuttgart: Enke; 2002: 369-370.
    Google Scholar
  • 14 Guillot M, Alexander K, Pomar C, del Castillo JRE. In growing pigs, chlortetracycline induces a reversible green bone discoloration and a persistant increase of bone mineral density dependent of dosing regimen. Res Vet Sci 2001; 90: 484-490.
    PubMedGoogle Scholar
  • 15 Heinonen M, Oravainen J, Orro T, Seppä-Lassila L, Ala-Kurikka E, Virolainen J, Tast A, Peltoniemi OA. Lameness and fertility of sows and gilts in randomly selected loose-housed herds in Finland. Vet Rec 2006; 159: 383-387.
    CrossrefPubMedGoogle Scholar
  • 16 Johansson S, Lind PM, Hakansson H, Oxlund H, Orberg J, Melhus H. Subclinical hypervitaminosis A causes fragile bones in rats. Bone 2002; 31: 685-689.
    CrossrefPubMedGoogle Scholar
  • 17 Jung H, Gasque L, Ruiz-Ramirez L, Moreno-Esparza R. Influence of the diet on bioavailability of tetracycline. J Inorg Biochem 1993; 51: 407.
    CrossrefPubMedGoogle Scholar
  • 18 Kamphues J. Schweine. In: Supplemente zu Vorlesungen und Übungen in der Tierernährung. Kamphues J, Schneider D, Leibetseder J. Hsrg. Alfeld-Hannover: Schaper; 1999: 211-235.
    Google Scholar
  • 19 Kephart KB, Harper MT, Raines CR. Observations of market pigs following transport to a packing plant. J Anim Sci 2010; 88: 2199-2203.
    CrossrefPubMedGoogle Scholar
  • 20 Lauritsen KT, Hagedorn-Olsen T, Friis NF, Lind P, Jungersen G. Absence of strictly age-related resistance to Mycoplasma hyosynoviae infection in 6-week-old-pigs. Vet Micro 2008; 130: 385-390.
    CrossrefPubMedGoogle Scholar
  • 21 Mason SE, Baynes RE, Almond GW, Riviere JE, Scheidt AB. Pharmacology of tetracycline water medication in swine. J Anim Sci 2009; 87: 3179-3186.
    CrossrefPubMedGoogle Scholar
  • 22 Milch RA, Rall DP, Tobie JE. Bone localisation of the tetracyclines. J Nat Cancer Institute 1957; 19: 87-91.
    PubMedGoogle Scholar
  • 23 Mustonen K, Ala-Kurikka E, Orro T, Peltoniemi O, Raekallio M, Vainio O, Heinonen M. Oral ketoprofen is effective in the treatment of non-infectious lameness in sows. Vet J 2011; 190: 55-59.
    CrossrefPubMedGoogle Scholar
  • 24 Nielsen EO, Nielsen NC, Fries NF. Mycoplasma hyosynoviae arthritis in grower-finisher pigs. J Vet Med A Physiol Pathol Clin Med 2001; 48: 475-486.
    CrossrefPubMedGoogle Scholar
  • 25 NRC. 1987. Vitamin Tolerance of Animals. Washington, DC: National Academy Press;
    Google Scholar
  • 26 Papich MG. Current concepts in antimicrobial therapy for horses. Proc Annu Con AAEP 2001; 94-102.
    PubMedGoogle Scholar
  • 27 Partanen K, Siljander-Rasi H, Karhapää M, Ylivainio K, Tupasela T. Responses of growing pigs to different dietary levels of phosphorus – performance, bone characteristics and solubility of faecal phosphorus. Livestock Sci 2010; 134: 109-112.
    CrossrefPubMedGoogle Scholar
  • 28 Pijpers A, Schoevers EJ, Haagsma N, Verheijden JH. Plasma levels of oxytetracycline, doxycycline and minocycline in pigs after oral administration in feed. J Anim Sci 1991; 69: 4512-4522.
    CrossrefPubMedGoogle Scholar
  • 29 Reeve-Johnson L. Water medication and the treatment of respiratory diseases in pigs. The Pig Journal 1998; 42: 74-86.
    PubMedGoogle Scholar
  • 30 Resse DE, Miller P. Nutrient deficiencies and excesses. In: Diseases of Swine. Zimmerman JJ, Karriker LA, Ramirez A, Schwartz KJ, Stevenson GW. eds. Ames: Wiley-Blackwell; 2012: 923-937.
    Google Scholar
  • 31 Reiner G, Hertrumpf B, Köhler K. Vitamin-A-Intoxikation beim Schwein. Tierärztl Prax 2004; 32 (G) 218-224.
    PubMedGoogle Scholar
  • 32 Rifkin BR, Vernillo AT, Golub LM, Ramamurthy NS. Modulation of bone resorption by tetracyclines. Ann N Y Acad Sci 1994; 732: 165-180.
    CrossrefPubMedGoogle Scholar
  • 33 Scott K, Chennells DJ, Campbell FM, Hunt B, Armstrong D, Taylor L. The welfare of finishing pigs in two contrasting housing systems: fully slatted versus straw-bedded accommodation. Livestock Sci 2006; 103: 104-115.
    CrossrefPubMedGoogle Scholar
  • 34 Stockland WL, Blaylock LG. Influence of dietary calcium and phosphorus levels on the performance and bone characteristics of growing-finishing swine. J Anim Sci 1973; 37: 906-912.
    CrossrefPubMedGoogle Scholar
  • 35 Waldmann KH, Wendt M. Der Tierarzt im Schweinebestand: Bestandsbetreuung. In: Lehrbuch der Schweinekrankheiten. Waldmann KH, Wendt M. Hrsg. Stuttgart: Parey; 2004: 29.
    Google Scholar
  • 36 Anonym. 2001 Verordnung zum Schutz landwirtschaftlicher Nutztiere und anderer zur Erzeugung tierischer Produkte gehaltener Tiere bei ihrer Haltung. 25.10.2001. Abschnitt 5 §22. BGBI. I S. 3223 vom 01. Oktober 2009
    PubMedGoogle Scholar
  • 37 von Wachenfelt H. Effect of floor condition on pig gait: a kinematic and kinetic study. [PhD thesis] Alnarp, Sweden: Swedish University of Agricultural Science; 2009
    Google Scholar