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Tierarztl Prax Ausg G Grosstiere Nutztiere 2006; 34(03): 171-178
DOI: 10.1055/s-0037-1621066
Schwein
Schattauer GmbH

Genetische Aspekte der Fruchtbarkeit beim Schwein

Genetic aspects of fertility in swine
G. Reiner
1   Aus der Klinik für Wiederkäuer und Schweine (Innere und Chirurgie) (geschäftsf. Direktor: Prof. Dr. Dr. habil. G. Reiner) der Justus-Liebig-Universität Gießen
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Further Information

Publication History

Eingegangen: 02 May 2005

akzeptiert: 04 July 2005

Publication Date:
10 January 2018 (online)

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Zusammenfassung:

Für den genetischen Anteil der Fruchtbarkeit lässt sich in den letzten drei Jahrzehntenbei den einschlägigen Rassen praktisch keine Steigerung beobachten. Die Ursache hierfür istzum großen Teil in der geringen Erblichkeitder Merkmale, aber auch in der geringen Selektionsintensitätzu suchen. Letztere wird dadurch erschwert, dass die Selektionsmerkmale geschlechtsbegrenzt sind, erst in fortgeschrittenem Alter der Tiere zurVerfügung stehen und sich aufgrund derausgeprägten Umwelteinflüsse sehr aufwendig und ungenau in der Erfassung darstellen. Ein wichtiges Ziel fürdie Zukunft ist daherdie Ergänzung der phänotypischen Selektion durch die direkte Berücksichtigung der DNA-Ebene mittels Genmarkern. Die vorliegende Arbeit zeigt den aktuellen Stand der Forschung auf dem Weg zur Entwicklung von Genmarkern und Kandidatengenen sowie deren Einsatz in der züchterischen Praxis.

Summary:

Reproductive traits in common pig breeds have not been improved during the last thirty years. The major reasons for this are: The traits of interest are expressed in females and at a late age only, they display low heritabilities and they are difficult to record due to overlaying environmental factors. Thus, a major goal for the future is to complement classical quantitative genetic selection strategies allowing directly for the DNA-level by gene markers. The present paper describes the relevant state of research on gene markers and candidate genes and their use in breeding practice.

Schlüsselwörter:

Schwein - Fruchtbarkeit - QTL-Kandidatengene

Key words:

Swine - fertility - QTL - candidate genes
 

  • Literatur

  • 1 Andersson L, Edfors-Lilja I, Ellegren H, Johansson M, Marklund L. Mapping trait loci by crossbreeding genetically divergent populations of domestic animals. Anim Biotechn 1994; 5: 225-31.
    PubMedGoogle Scholar
  • 2 Avalos E, Smith C. Genetic improvement of litter size in pigs. Anim Prod 1987; 44: 153-64.
    CrossrefPubMedGoogle Scholar
  • 3 Benett GL, Leymaster KA. Integration of ovulation rate, potential embryonic variability and uterine capacity into amodel of litter size in swine. J Anim Sci 1989; 67: 1230-41.
    CrossrefPubMedGoogle Scholar
  • 4 Brandt H, Götz KU. Das Tiermodell in der Schweinezucht. Welche Vorteile bringt die BLUP-Zuchtwertschätzung nach dem Tiermodell?. Tierzüchter 1989; 41: 532-3.
    PubMedGoogle Scholar
  • 5 Braunschweig MH, Paszek AA, Weller JI, Da Y, Hawken RJ, Wheeler MB, Schook LB, Alexander LJ. Generation and exploration of a dense genetic map in a region of a QTL affecting corpora lutea in a Meishan x Yorkshire cross. Mamm Genome 2001; 12: 719-23.
    CrossrefPubMedGoogle Scholar
  • 6 Caetano AR, Johnson RK, Pomp D. Generation and sequence characterization of a normalized cDNA library from swine ovarian follicles. Mamm Genome 2003; 14: 65-70.
    CrossrefPubMedGoogle Scholar
  • 7 Campbell EM, Nonneman D, Rohrer GA. Fine mapping a quantitative trait locus affecting ovulation rate in swine on chromosome 8. J Anim Sci 2003; 81: 1706-14.
    CrossrefPubMedGoogle Scholar
  • 8 Cassady JP, Johnson RK, Ford JJ. Comparison of plasma FSH concentration in boars and gilts from lines selected for ovulation rate and embryonal survival, and litter size and estimation on (co)variance components for FSH and ovulation rate. J Anim Sci 2000; 78: 1430-5.
    CrossrefPubMedGoogle Scholar
  • 9 Cassady JP, Johnson RK, Pomp D, Rohrer GA, Van Vleck LD, Spiegel EK, Gilson KM. Identification of quantitative trait loci affecting reproduction in pigs. J Anim Sci 2001; 79: 623-33.
    CrossrefPubMedGoogle Scholar
  • 10 Geisert RD, Zavy MT, Moffatt RJ, Blair M, Yellin T. Embryonic steroids and the establishment of pregnancy in pigs. J Reprod Fertil Suppl 1990; 40: 293-305.
    PubMedGoogle Scholar
  • 11 Geldermann H. Investigations on inheritance of quantitative characters in animals by gene markers. I. Methods. Theor Appl Genet 1975; 46: 310-30.
    PubMedGoogle Scholar
  • 12 Geldermann H, Müller E, Moser G, Reiner G, Bartenschlager H, Cepica S, Stratil A, Kuryl J, Moran C, Davoli R, Brunsch C. Genome-wide linkage and QTL mapping in porcine F2 families generated from Pietrain, Meishan and Wild Boar crosses. J Anim Breed Genet 2003; 120: 363-93.
    CrossrefPubMedGoogle Scholar
  • 13 Gladney CD, Bertani GR, Johnson RK, Pomp D. Evaluation of gene expression in pigs selected for enhanced reproduction using differential display PCR and human microarrays: I. Ovarian follicles. J Anim Sci 2004; 82: 17-31.
    CrossrefPubMedGoogle Scholar
  • 14 Hadley ME. Endocrinology. Prentice Hall, Upper Saddle River. NJ: 1996
    Google Scholar
  • 15 Haley CS, Lee GJ. Genetic factors contributing to variation in litter size in British Large White gilts. Livest Prod Sci 1992; 30: 99-113.
    CrossrefPubMedGoogle Scholar
  • 16 Haley CS, Lee GJ. Genetic basis for prolificacy in Meishan pigs. J Reprod Fertil Suppl 1993; 48: 247-59.
    PubMedGoogle Scholar
  • 17 Hamann HC, Drögmüller C, Krieter J, Presuhn U, Wallenburg J, Distl O. Genetic markers for litter size in German pig breeds. In: Proc. 51th Ann. Meet. Europ. Assoc. Anim. Prod. Den Haag: 2000. G1 24.
    Google Scholar
  • 18 Harney JP, Mirando MA, Smith LC, Bazer FW. Retinol-binding protein: A major secretory product of the pig conceptus. BiolReprod 1990; 42: 523-32.
    PubMedGoogle Scholar
  • 19 Hiendleder S, Reiner G, Geldermann H, Dzapo V. SNPs in the porcine INHA gene and linkage mapping to SSC15. Anim Genet 2002; 33: 247-8.
    CrossrefPubMedGoogle Scholar
  • 20 Hirooka H, DeKoning DJ, Harlizius B, Van Arendonk JA, Rattink AP, Groenen MA, Brascamp EW, Bovenhuis H. A whole genome scan for quantitative trait loci affecting teatnumber in pigs. J Anim Sci 2001; 79: 2320-6.
    CrossrefPubMedGoogle Scholar
  • 21 Holl JW, Robinson OW. Results from nine generations of selection for increased litter size in swine. J Anim Sci 2003; 81: 624-9.
    CrossrefPubMedGoogle Scholar
  • 22 Hu ZL, Abbott MA, Yerle M, Rothschild MF. Rapid communication: The progesterone receptor (PGR) gene maps to porcine chromosome 9p13-p11 by arodent-porcine somatic cell hybrid panel. JAnim Sci 1998; 76: 2749-50.
    PubMedGoogle Scholar
  • 23 Irgang R, Favero JA, Kennedy BW. Genetic parameters for litter size of different parities in Duroc, Landrace, and Large White sows. J Anim Sci 1994; 72: 2237-46.
    CrossrefPubMedGoogle Scholar
  • 24 Jiang Z, Gibson JP, Archibald AL, Haley CS. The porcine gonadotropin-re- leasing hormone receptor gene (GNRHR): genomic organization, polymorphisms, and association with the number of corpora lutea. Genome 2001; 44: 7-12.
    CrossrefPubMedGoogle Scholar
  • 25 Johnson RK, Nielsen MK, Casey DS. Responses in ovulation rate, embryonal survival, and litter traits in swine to 14 generations of selection to increase litter size. J Anim Sci 1999; 77: 541-57.
    CrossrefPubMedGoogle Scholar
  • 26 King AH, Jiang Z, Gibson JP, Haley CS, Archibald AL. Mapping quantitative trait loci affecting female reproductive traits on porcine chromosome 8. Biol Reprod 2003; 68: 2172-9.
    CrossrefPubMedGoogle Scholar
  • 27 Knoll A, Cepica S, Stratil A, Nebola M, Dvorak J. Numerous PCR-RFLPs within the porcine CYP21 (steroid 21-hydroxylase) gene. Anim Genet 1998; 29: 402-3.
    PubMedGoogle Scholar
  • 28 Lahbib-Mansais Y, Barbosa A, Yerle M, Parma P, Milan D, Pailhoux E, Gellin J, Cotinot C. Mapping in pig of genes involved in sexual differentiation: AMH, WT1, FTZF1, SOX2, SOX9, AHC, and placental and embryonic CYP19. Cytogenet Cell Genet 1997; 76: 109-14.
    CrossrefPubMedGoogle Scholar
  • 29 Legault C, Gruand J, Lebost J, Garreau H, Ollivier L, Messer LA, Rotschild MF. Frequence et effect sur la prolificite du gene ESR dans deux lignees Large White en France. J Rech Porc Franc 1996; 28: 9-14.
    PubMedGoogle Scholar
  • 30 Li N, Zhoa YF, Xiao L, Zang FJ, Chen YZ, Dai RJ, Zang JS, Shen SQ, Chen YF, Wu CX. Candidate gene analysis for identification of genetic loci controlling litter size in swine. In: 6th World Congress Genet. Appl. Livest. Prod. Armidale, Australia: 1998: 183-6.
    Google Scholar
  • 31 Lim H, Paria BC, Das SK, Dinchuk JE, Langenbach R, Traskos JR, Dey SK. Multiple female reproductive failures in cyclooxygenase 2-deficient mice. Cell 1997; 91: 197-208.
    CrossrefPubMedGoogle Scholar
  • 32 Linville RC, Pomp D, Johnson RK, Rothschild MF. Candidate gene analysis for loci affecting litter size and ovulation rate in swine. JAnim Sci 2001; 79: 60-7.
    PubMedGoogle Scholar
  • 33 Messer LA, Wang L, Legault C, Rothschild MF. Mapping and investigation of candidate genes for litter size in French Large White pigs. Anim Genet 1996; 27 Suppl.2 101-19.
    PubMedGoogle Scholar
  • 34 Miller EA, Ge Z, Hedgpeth V, Gadsby JE. Steroidogenic responses of pig corpora lutea to insulin-like growth factor I (IGF-I) throughout the oestrous cycle. Reproduction 2003; 125: 241-9.
    CrossrefPubMedGoogle Scholar
  • 35 Niggemeyer H. Sind französische Sauen so gut wie ihr Ruf?. Top Agrar 2003; 9: 12-3.
    PubMedGoogle Scholar
  • 36 Niggemeyer H. PIC will die Ferkelverluste senken. SUS 2004; 1: 44-7.
    PubMedGoogle Scholar
  • 37 Nonneman D, Rohrer GA. Molecular cloning of the porcine inhibin-betaB gene and reassignment to chromosome 15. Anim Genet 2003; 34: 213-5.
    CrossrefPubMedGoogle Scholar
  • 38 Ollivier L, Bolet GL. Selection for prolificacyinthe pig. Pig News Information 1982; 3: 383-8.
    PubMedGoogle Scholar
  • 39 Ollivier L, Messer LA, Rothschild MF, Legault C. The use of selection experiments for detecting quantitative trait loci. Genet Res 1997; 69: 227-32.
    CrossrefPubMedGoogle Scholar
  • 40 Plastow GS. Utilization of candidate genes and QTL in swine. In: VIth Plant & Animal Genome Conference. San Diego: 1998: 14.
    Google Scholar
  • 41 Rathje TA, Rohrer GA, Johnson RK. Evidence for quantitative trait loci affecting ovulation rate in pigs. J Anim Sci 1997; 75: 1486-94.
    CrossrefPubMedGoogle Scholar
  • 42 Reiner G. Evaluierung und Nutzung der natürlichen Krankheitsresistenz beim Schwein – aktueller Stand und Möglichkeiten. Tierärztl Prax 2002; 31 (G) 151-7.
    PubMedGoogle Scholar
  • 43 Rohrer GA, Ford JJ, Wise TH, Vallet JL, Christenson RK. Identification of quantitative trait loci affecting female reproduction traits in a multigeneration Meishan-White composite swine population. J Anim Sci 1999; 77: 1385-91.
    CrossrefPubMedGoogle Scholar
  • 44 Rohrer GA. Identification of quantitative trait loci affecting birth characters and accumulation of backfat and weight in Meishan-White Composite resource population. J Anim Sci 2000; 78: 2547-53.
    CrossrefPubMedGoogle Scholar
  • 45 Rohrer GA, Wise TH, Lunstra DD, Ford JJ. Identification of genomic regions controlling plasma FSH concentrations in Meishan-White Composite boars. Physiol Genomics 2001; 6: 145-51.
    CrossrefPubMedGoogle Scholar
  • 46 Rothschild MF, Jacobsen C, Vaske DA, Tuggle CK, Short TH, Sasaki S, Eckardt GR, McLaren DG. A major gene for litter size in pigs. In: Proc. 5th World Congress on Genetics Applied to Livestock Production. Guelph: 1994. 21 225-8.
    Google Scholar
  • 47 Rothschild MF, Jacobsen C, Vaske D, Tuggle CK, Wang L, Short TH, Eckardt G, Sasaki S, Vincent A, McLaren D, Southwood OI, Van der Steen A, Mileham A, Plastow GS. The estrogen receptor locus is associated with a major gene influencing litter size in pigs. Proc Natl Acad Sci USA 1996; 93: 201-5.
    CrossrefPubMedGoogle Scholar
  • 48 Rothschild MF, Bidanel JP. Biology and genetics of reproduction. In: The Genetics of the Pig. Rothschild MF, Ruvinsky A. eds. Wallingford, Oxon, UK: CAB International; 1998: 313-43.
    Google Scholar
  • 49 Rothschild MF, Messer L, Day A, Wales R, Short TH, Southwood OI, Plastow GS. Investigations on the retinol binding protein 4 (RBP4) gene as a candidate gene for increased litter size in pigs. Mamm Genome 2000; 11: 75-7.
    CrossrefPubMedGoogle Scholar
  • 50 Seeland G, Grosshans T, Distl O. Eignung verschiedener genetischer Modelle zur Schätzung von Heterosiseffekten bei Kreuzungen extremer Milchviehrassen. ArchTierz Dummerstorf 1993; 36: 265-76.
    PubMedGoogle Scholar
  • 51 Short TH, Rothschild MF, Southwood OI, McLaren DG, DeVries A, Van der Steen H, Eckardt GR, Tuggle CK, Helm J, Vaske DA, Mileham AJ, Plastow GS. Effect of the estrogen receptor locus on reproduction and production traits. J Anim Sci 1997; 75: 3138-42.
    CrossrefPubMedGoogle Scholar
  • 52 Spötter A, Drögemüller C, Kuiper H, Brenig B, Leeb T, Distl O. Molecular characterization and chromosomal assignment of the porcien gene for leukemia inhibitor factor LIF. Cytogenet Cell Genet 2001; 93: 87-90.
    CrossrefPubMedGoogle Scholar
  • 53 Steinheuer R. Schätzung von Varianzkomponenten und Kandidatengeneffekten für die paternale und maternale Komponente von Fruchtbarkeitsmerkmalen beim Schwein. Diss vet med. Hannover: 2001
    Google Scholar
  • 54 Vallet JL, Freking BA, Leymaster KA, Christenson RK. Allelic variation in the erythropoietin receptor gene is associated with uterine capacity and litter size in swine. Animal Genet 2005; 36: 97-103.
    CrossrefPubMedGoogle Scholar
  • 55 Van der Steen H, Southwood OI, Vries AG, Short TH, McLaren DG, Wie M, Plastow GS. Evidence of anew genetic marker for litter size in Meishan syn- thenic pigs. Proc. Intern. Conf.Anim. Biotechn 1997; 17-20.
    PubMedGoogle Scholar
  • 56 VanRens BTTM, Evans GJ, Van der Lende T. Components of litter size in gilts with different prolactin receptor genotypes. Theriogenology 2003; 59: 915-26.
    CrossrefPubMedGoogle Scholar
  • 57 Vincent AL, Short TH, Southwood OI, Plastow GS, Tuggle CK, Rothschild MF. The prolactin receptor gene is associated with increased litter size in pigs. In: Proc. 6th World Congress on Genetics Applied to Livestock Production, Armidale 1998; 27: 15-8.
    PubMedGoogle Scholar
  • 58 Wada Y, Akita T, Awata T, Furukawa T, Sugai N, Inage Y, Ishii K, Ito Y, Kobayashi E, Kusumoto H, Matsumoto T, Mikawa S, Miyake M. Quantitative trait loci (QTL) analysis in a Meishan x Göttingen cross population. Anim Genet 2000; 31: 376-84.
    CrossrefPubMedGoogle Scholar
  • 59 Wilkie PJ, Paszek AA, Beattie CW, Alexander LJ, Wheeler MB, Schook LB. A genomic scan of porcine reproductive traits reveals possible quantitative trait loci (QTLs) for number of corpora lutea. Mamm Genome 1999; 10: 573-8.
    CrossrefPubMedGoogle Scholar
  • 60 Yelich J, Pomp D, Geisert R. Detection of transcripts for retinoic acid receptors, retinal-binding protein, and transforming growth factor during rapid trophoblastic elongation in the porcine conceptus. Biol Reprod 1997; 57: 286-94.
    CrossrefPubMedGoogle Scholar
  • 61 ZDS: Schweineproduktion in Deutschland. 2003 Zentralverband der Deutschen Schweineproduktion, Bonn
    PubMedGoogle Scholar