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Nuklearmedizin 1979; 18(01): 26-35
DOI: 10.1055/s-0037-1620871
Originalarbeiten - Original Articles
Schattauer GmbH

99mTc-Unithiol Complex, a New Radiopharmaceutical for Kidney Scintigraphy

III. Studies of Labelling Unithiol with 99mTc 99mTc-Unithiol-Komplex, ein neues Radiopharmazeutikum für die Nierenszintigraphie.III. Untersuchungen über die Markierung von Unithiol mit 99mTc
L. Darte
1   From the Department of Radiation Physics, University of Lund, Lasarettet, Lund, Sweden
,
M. Oginski
1   From the Department of Radiation Physics, University of Lund, Lasarettet, Lund, Sweden
,
R. B. R. Persson
1   From the Department of Radiation Physics, University of Lund, Lasarettet, Lund, Sweden
› Author Affiliations
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Publication History

Received: 20 June 1978

Publication Date:
05 January 2018 (online)

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Labelling of 2, 3-dimercaptopropane sodiumsulphonate (Unithiol) with 99mTc resulted in essentially three components in the GCS pofile: the top zone, a low-molecular Complex A and a high-molecular Complex B. In the presence of tin metal a fourth component, Complex C, could be distinguished. Complex A was relatively independent of pH, the proportion of Complex B increased with increasing pH. Methods were developed for preparing, with over 80% labelling efficiency, either Complex A or Complex B, each having high stability in the preparation vials and in human blood.

Die Markierung von 2,3-dimercaptopropannatriumsulfonat (Unithiol) mit 99mTc ergab im Wesentlichen drei Komponenten im Gel-Säulenchromatogramm: die oberste Zone, einen niedermolekularen Komplex A und einen hochmolekularen Komplex B. In Gegenwart von metallischem Zinn konnte eine vierte Komponente, Komplex C, erkannt werden. Der Komplex A war vom pH-Wert relativ unabhängig, während der Anteil an Komplex B mit steigendem pH größer wurde. Es wurden Methoden der Herstellung - mit 80 %iger Markierungseffizienz - von entweder Komplex A oder Komplex B entwickelt, wobei das jeweilige Produkt sowohl in der Eprouvette als auch in menschlichem Blut sehr stabil war.

 

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