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Thromb Haemost 1999; 82(05): 1403-1405
DOI: 10.1055/s-0037-1614844
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Schattauer GmbH

Elevated High Molecular Weight Fibrinogen in Plasma Is Predictive of Coronary Ischemic Events after Acute Myocardial Infarction

Edelmiro Reganon
1   From the Research Center, Coronary Care Unit and Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
,
Virtudes Vila
1   From the Research Center, Coronary Care Unit and Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
,
Fernando Ferrando
1   From the Research Center, Coronary Care Unit and Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
,
Vicenta Martínez-Sales
1   From the Research Center, Coronary Care Unit and Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
,
Laura Fayos
2   Coronary Care Unit and Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
,
Miguel Ruano
2   Coronary Care Unit and Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
,
Justo Aznar
3   Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain
› Author Affiliations
Further Information

Publication History

Received 19 March 1999

Accepted after revision 16 June 1999

Publication Date:
09 December 2017 (online)

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Summary

This study investigates the association between the concentration and function of plasma fibrinogen molecules measured at the time of hospital admission in patients with acute myocardial infarction (AMI), with reference to the risk of new coronary ischemic events during a three-day follow-up period of. Before starting fibrinolytic and anticoagulant treatment plasma fibrinogen, high molecular weight fibrinogen (HMW-fibrinogen), fibrin formation rate (FbFR) and phosphorous content in fibrinogen were determined in 90 AMI patients. During a three-day follow-up period 12 patients suffered new ischemic events. The 12 patients with coronary ischemia had higher concentrations of plasma fibrinogen (312 ± 23 vs. 270 ± 73 mg/dl, p <0.05) and HMW-fibrinogen (246 ± 35 vs. 189 ± 23 mg/dl, p <0.001) and a higher FbFR (65 ± 30 vs. 40 ± 25, p <0.001) than patients without these events. No association was found between the phosphorous content in fibrinogen and new coronary ischemic events. We conclude that after myocardial infarction an elevated plasma level of HMW-fibrinogen and a high FbFR value at the time of hospital admission are associated with new coronary ischemic events during a three-day follow-up period.

Keywords

Fibrinogen - HMW-fibrinogen - fibrin - myocardial infarction - coronary ischemic events
 

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