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Thromb Haemost 1999; 82(01): 10-13
DOI: 10.1055/s-0037-1614621
Rapid Communication
Schattauer GmbH

Lipoprotein(a) Concentrations in Women with a History of Severe Preeclampsia – a Case Control Study

Maria G. van Pampus
1   From the Departments of Gynaecology and Obstetrics, the Centre for Haemostasis, Thrombosis, Atherosclerosis and Inflammation Research, and Department of Clinical Epidemiology and Biostatistics, Academic Medical Centre, Amsterdam, The Netherlands
,
Maria M. W. Koopman
1   From the Departments of Gynaecology and Obstetrics, the Centre for Haemostasis, Thrombosis, Atherosclerosis and Inflammation Research, and Department of Clinical Epidemiology and Biostatistics, Academic Medical Centre, Amsterdam, The Netherlands
,
Hans Wolf
1   From the Departments of Gynaecology and Obstetrics, the Centre for Haemostasis, Thrombosis, Atherosclerosis and Inflammation Research, and Department of Clinical Epidemiology and Biostatistics, Academic Medical Centre, Amsterdam, The Netherlands
,
Harry R. Büller
1   From the Departments of Gynaecology and Obstetrics, the Centre for Haemostasis, Thrombosis, Atherosclerosis and Inflammation Research, and Department of Clinical Epidemiology and Biostatistics, Academic Medical Centre, Amsterdam, The Netherlands
,
Martin H. Prins
1   From the Departments of Gynaecology and Obstetrics, the Centre for Haemostasis, Thrombosis, Atherosclerosis and Inflammation Research, and Department of Clinical Epidemiology and Biostatistics, Academic Medical Centre, Amsterdam, The Netherlands
,
Abraham van den Ende
1   From the Departments of Gynaecology and Obstetrics, the Centre for Haemostasis, Thrombosis, Atherosclerosis and Inflammation Research, and Department of Clinical Epidemiology and Biostatistics, Academic Medical Centre, Amsterdam, The Netherlands
› Author Affiliations
Further Information

Publication History

Received 04 May 1998

Accepted after resubmission 14 April 1999

Publication Date:
11 December 2017 (online)

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Summary

A high concentration of lipoprotein(a) is associated with athero-sclerotic disease. Atheroma may develop in spiral arteries in both preeclamptic and normal pregnancies, but they are much more common in preeclampsia, particularly in the decidual segments. We hypothesized that a high concentration of lipoprotein(a) is associated with the development of preeclampsia.

We studied 40 women with a history of severe preeclampsia, 35 women with a history of preeclampsia and the (H)ELLP syndrome and 67 controls with a normal obstetric history. Lipoprotein(a) levels were measured at least 10 weeks post partum in the second half of a normal menstrual cycle. None of the women in the study or the control group were pregnant or used oral contraceptives. Lipoprotein(a) levels over the 90th percentile of the lipoprotein(a) distribution of our control group (420 mg/l) were defined as abnormal. There was a statistically significant higher prevalence of abnormal levels of lipoprotein(a) in women with a history of severe preeclampsia (33%) in comparison with women with a history of preeclampsia and (H)ELLP syndrome (9%) and with the control group (10%).

We found that a history of severe preeclampsia and spontaneous abortion was associated with elevated lipoprotein(a) levels as a post-hoc finding. Whether spontaneous abortion and high levels of lipo-protein(a) are related remains to be demonstrated.

 

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