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Thromb Haemost 1999; 81(06): 910-912
DOI: 10.1055/s-0037-1614597
Letters to the Editor
Schattauer GmbH

Age- and Sex-related Differences of Plasma Activated Factor VII Levels in Children

Toshiyuki Sakata
1   From Laboratory of Clinical Chemistry, and Suita, Osaka, Tochigi, Japan
,
Taku Yamamura
2   Research Institute, National Cardiovascular Center, Suita, Osaka, and the Tochigi, Japan
,
Kazuomi Kario
3   Department of Cardiology, Jichi Medical School, Tochigi, Japan
,
Yoshiaki Katayama
1   From Laboratory of Clinical Chemistry, and Suita, Osaka, Tochigi, Japan
,
Tatsuo Matsuyama
1   From Laboratory of Clinical Chemistry, and Suita, Osaka, Tochigi, Japan
,
Hisao Kato
2   Research Institute, National Cardiovascular Center, Suita, Osaka, and the Tochigi, Japan
,
Akira Yamamoto
2   Research Institute, National Cardiovascular Center, Suita, Osaka, and the Tochigi, Japan
,
Toshiyuki Miyata
2   Research Institute, National Cardiovascular Center, Suita, Osaka, and the Tochigi, Japan
› Author AffiliationsThis work was supported in part by grants-in-aid from Special Coordination Funds for Promoting Science and Technology (Encouragement System of COE), the Science and Technology Agency of Japan and from the Ministry of Education, Science, Sports, and Culture of Japan
Further Information

Publication History

Received 05 May 1998

Accepted after resubmission 11 March 1999

Publication Date:
09 December 2017 (online)

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Summary

Although the majority of factor VII (FVII) circulates in the zymogen form, low levels of activated factor VII (FVIIa) exist in plasma and play an important role in the initiation of tissue factor-induced coagulation. It has been reported that the concentrations of hemostatic components in children and adults are different. Here, we investigated the age- and sex-related differences of FVIIa and FVII antigen (FVIIag) levels in children at age of 10 (n = 123; males: n = 62; females: n = 61), and 13 (n = 105; males: n = 47; females: n = 58), and compared these levels with those of young adults (mean ± SD of age: 29.6 ± 6.0 years). In males, there was not a significant difference between the FVIIa levels of 10-year-old children and 13-year-old children, but the FVIIa levels in adult controls were significantly higher than those in children. In females, the FVIIa levels in 13-year-old children were significantly higher than that in 10-year-old children, but there was not a significant difference between 13-year-old children and adults. Thus, our study showed that plasma FVIIa levels were lower in children than in adults, and the increase of FVIIa level was earlier in females than in males.

 

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