Thromb Haemost 1999; 82(03): 1197-1198
DOI: 10.1055/s-0037-1614353
Letters to the Editor
Schattauer GmbH

Lack of Association between Hemochromatosis and Factor V Leiden Mutations in the Czech Population

Ingrid Hrachovinova
1   From the 1Institute of Haematology and Blood Transfusion, and Faculty Hospital, 1. Medical Faculty UK, Prague, Czech Republic
,
Blanka Rypackova
2   Department of Haematology, Faculty Hospital, 1. Medical Faculty UK, Prague, Czech Republic
,
Daniel Vyoral
1   From the 1Institute of Haematology and Blood Transfusion, and Faculty Hospital, 1. Medical Faculty UK, Prague, Czech Republic
› Author Affiliations
Further Information

Publication History

Received 29 March 1999

Accepted after revision 20 April 1999

Publication Date:
09 December 2017 (online)

 

 
  • References

  • 1 Xie YD, Lillicrap DP, Taylor SAM. An association between the common hereditary hemochromatosis mutation and the factor V Leiden allele in a population with thrombosis. Blood 1998; 92: 1461-2.
  • 2 Andrews NC, Levy JE. Iron is hot: An update on the pathophysiology of hemochromatosis. Blood 1998; 92: 1845-51.
  • 3 Bertina RM, Koeleman BP, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, van der Velden PA, Reitsma PH. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369: 64-7.
  • 4 Lynas C. A cheaper and more rapid polymerase chain reaction-restriction fragment length polymorphism method for the detection of the HLA-H gene mutation occurring in hereditary hemochromatosis. Blood 1997; 90: 4235-6.
  • 5 Tordai A, Andrikovics H, Kalmár L, Rajczy K, Pénzes M, Sarkadi B, Klein I, Váradi A. High frequency of the haemochromatosis C282Y mutation in Hungary could argue against a Celtic origin of the mutation. J Med Genet 1998; 35: 878-9.
  • 6 Nielsen P, Carpinteiro S, Fischer R, Cabeda JM, Porto G, Gabbe EE. Prevalence of the C282Y and H63D mutations in the HFE gene in patients with hereditary haemochromatosis and in control subjects from Northern Germany. Br J Haematol 1998; 103: 842-5.