Thromb Haemost 2000; 84(05): 926-927
DOI: 10.1055/s-0037-1614144
Letters to the Editor
Schattauer GmbH

Impact of the -455G>A Promoter Polymorphism in the B Fibrinogen Gene on Stimulated Fibrinogen Production following Bypass Surgery

J. M. Cotton
1   From the Department of Cardiology, Kings College, GKT School of Medicine and Dentistry, London, England and the Centres for
,
K. E. Webb
2   Cardiovascular Genetics and University College Medical School, University College London, London, England
,
A. Mathur
3   Vascular Biology and Medicine, Royal Free and University College Medical School, University College London, London, England
,
J. F. Martin
3   Vascular Biology and Medicine, Royal Free and University College Medical School, University College London, London, England
,
S. E. Humphries
2   Cardiovascular Genetics and University College Medical School, University College London, London, England
› Author Affiliations
This work was supported by the British Heart Foundation (RG95007, RG98911). JMC is a BHF junior research fellow.
Further Information

Publication History

Received 26 June 2000

Accepted after revision 10 July 2000

Publication Date:
13 December 2017 (online)

 

 
  • References

  • 1 Meade TW, Mellows S, Brozovic M, Miller GJ, Chakrabarti RR, North WR, Haines AP, Stirling Y, Imeson JD, Thomson SG. Haemostatic function and ischaemic heart disease: principal results of the Northwick Park Heart Study Lancet. 1986; 02: 533-7.
  • 2 Foulkes FGR. Fibrinogen and peripheral arterial disease. European Heart Journal 1995; 16 (Suppl A) 36-41.
  • 3 Kannel WB, Wolf PACastelli, D’Agostino RB. Fibrinogen and risk of cardiovascular disease. The Framingham Study. JAMA 1987; 258: 1183-6.
  • 4 Balleisen L, Bailey J, Epping P-H, Schulte H, van der Loo J. Epidemiological study on factor VII, factor VIII and fibrinogen in an industrial population: baseline data on the relation to age, gender, body-weight, smoking, alcohol, pill-using and menopause. Thromb Haemost 1985; 54: 475-9.
  • 5 Meade TW, Imerson J, Stirling Y. Effects of changes in smoking and other characteristics on clotting factors and the risk of ischaemic heart disease. Lancet 1987; 02: 986-8.
  • 6 Tybjaerg-Hansen A, Agerholm-Larsen B, Humphries SE, Abildgaard S, Schnohr P, Nordestgaard BG. A common mutation (G-455-A) in the β-fibrinogen promoter is an independent predictor of plasma fibrinogen but not of ischemic heart disease. J Clin Invest 1997; 99: 3034-9.
  • 7 Hamsten A, Iselius L, de Faire U, Blombuck M. Genetic and cultural inheritance of plasma fibrinogen concentration. Lancet 1987; 02: 988-91.
  • 8 Friedlander Y, Elkana Y, Sinnreich R, Kark JD. Genetic and environmental sources of fibrinogen variability in Israeli families: The Kibbutzim Family Study. Am J Hum Genet 1995; 56: 1194-206.
  • 9 Humphries SE, Luong L-A, Mongomery HE, Day INM, Mohamed-Ali V, Yudkin JS. Gene environment interaction in the determination of levels of plasma fibrinogen. Thromb Haemost 1999; 82: 818-25.
  • 10 Thomas AE, Green FR, Kelleher CH, Wilkes HC, Brennan PJ, meade TW, Humphries SE. Variation in the promoter region of the β fibrinogen gene is associated with plasma fibrinogen levels in smokers and non-smokers. Thromb Haemost 1991; 65: 487-90.
  • 11 Humphries SE, Henry JA, Montgomery HE. Gene-environment interaction in the determination of levels of haemostatic variables involved in thrombosis and fibrinolysis. Blood Coagul Fibrinolysis 1999; 10 (Suppl. 01) S17-21.
  • 12 Montgomery HE, Clarkson PE, Nwose OM, Mikailidis DP, Jagroop IA, Dollery C, Moult J, Benhizia F, Deanfield J, Jubb M, World M, McEwan JR, Winder A, Humphries S. The acute rise in plasma fibrinogen concentration with exercise is influenced by the G-453-A polymorphism of the beta-fibrinogen gene. Arterioscler Thromb Vasc Biol 1996; 16: 386-91.
  • 13 Gardemann A, Schwartz O, Haberbosch W, Katz N, Weiss T, Tillmanns H, Hehrlein FW, Waas W, Eberbach A. Positive association of the β fibrinogen H1/H2 gene variation to basal fibrinogen levels and to the increase in fibrinogen concentration during acute phase reaction but not to coronary artery disease and myocardial infarction. Thromb Haemost 1997; 77: 1120-6.
  • 14 de Maat MP, Kastelein JJ, Jukema JW, Zwinderman AH, Jansen H, Groe Bnemeier, Bruschke AV, Kluft C. -455G/A polymorphism of the beta fibrinogen gene is associated with the progression of coronary atherosclerosis in symptomatic men: proposed role for an acute-phase reaction pattern of fibrinogen. REGRESS group. Arterioscler Thromb Vasc Biol 1998; 18: 265-71.
  • 15 Roy SN, Mukhopadhyay G, Redman CM. Regulation of fibrinogen assembly: transfection of HepG2 cells with B beta cDNA specifically enhances synthesis of the three component chains of fibrinogen. J Biol Chem 1990; 265: 2117-24.
  • 16 van’t Hooft FM, von Bahr SJF, Silveira A, Iliadou A, Eriksson P, Hamsten A. Two common, functional polymorphisms in the promoter region of the β-fibrinogen gene contribute to regulation of plasma fibrinogen concentration. Arterioscler Thromb Vasc Biol 1999; 19: 3063-70.
  • 17 Bolla MK, Haddad L, Humphries SE, Winder AF, Day IN. High-throughput method for determination of apolipoprotein E genotypes with use of restriction digestion analysis by microplate array diagonal gel electrophoresis. Clin Chem 1995; 41: 1599-604.