Download PDF
Thromb Haemost 2000; 83(06): 963-964
DOI: 10.1055/s-0037-1613951
Letters to the Editor
Schattauer GmbH

In the Presence of other Inherited or Acquired High-risk Situations, the FV Cambridge Mutation May Be an Additional Thrombophilic Risk Factor, through Its Effect on APC Sensitivity

Rosa Santacroce
From Unita’ di Aterosclerosi e Trombosi, I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo, Divisione di Ematologia, Unità di Coagulazione, Ospedale “A. Cardarelli”, Napoli, Istituto di Medicina Interna e Geriatria, Università di Palermo, Italy; and Molecular Biology Diagnostic Unit, Children’s Hospital of Philadelphia, University of Pennsylvania School of Medicine, USA
,
Anna Bossone
From Unita’ di Aterosclerosi e Trombosi, I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo, Divisione di Ematologia, Unità di Coagulazione, Ospedale “A. Cardarelli”, Napoli, Istituto di Medicina Interna e Geriatria, Università di Palermo, Italy; and Molecular Biology Diagnostic Unit, Children’s Hospital of Philadelphia, University of Pennsylvania School of Medicine, USA
,
Vincenzo Brancaccio
From Unita’ di Aterosclerosi e Trombosi, I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo, Divisione di Ematologia, Unità di Coagulazione, Ospedale “A. Cardarelli”, Napoli, Istituto di Medicina Interna e Geriatria, Università di Palermo, Italy; and Molecular Biology Diagnostic Unit, Children’s Hospital of Philadelphia, University of Pennsylvania School of Medicine, USA
,
Paolo Fortina
From Unita’ di Aterosclerosi e Trombosi, I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo, Divisione di Ematologia, Unità di Coagulazione, Ospedale “A. Cardarelli”, Napoli, Istituto di Medicina Interna e Geriatria, Università di Palermo, Italy; and Molecular Biology Diagnostic Unit, Children’s Hospital of Philadelphia, University of Pennsylvania School of Medicine, USA
,
Maurizio Margaglione
From Unita’ di Aterosclerosi e Trombosi, I.R.C.C.S. “Casa Sollievo della Sofferenza”, S. Giovanni Rotondo, Divisione di Ematologia, Unità di Coagulazione, Ospedale “A. Cardarelli”, Napoli, Istituto di Medicina Interna e Geriatria, Università di Palermo, Italy; and Molecular Biology Diagnostic Unit, Children’s Hospital of Philadelphia, University of Pennsylvania School of Medicine, USA
› Author Affiliations
Further Information

Publication History

Received 20 December 1999

Accepted after resubmission 29 January 2000

Publication Date:
14 December 2017 (online)

    Permissions and Reprints

 

 

  • References

  • 1 Dahlbäck B. Physiological anticoagulation. Resistance to activated protein C and venous thromboembolism. J Clin Invest 1994; 94: 923-7.
    CrossrefPubMedGoogle Scholar
  • 2 Rodeghiero F, Tosetto A. Activated protein C resistance and Factor V Leiden mutation are independent risk factors for venous thromboembolism. Ann Intern Med 1999; 130: 643-50.
    CrossrefPubMedGoogle Scholar
  • 3 Bernardi F, Faioni EM, Castoldi E, Lunghi B, Castaman G, Sacchi E, Mannucci PM. A factor V genetic component differing from factor V R506Q contributes to the activated protein C resistance phenotype. Blood 1997; 90: 1552-7.
    PubMedGoogle Scholar
  • 4 Williamson D, Brown K, Luddington R, Baglin C, Baglin T. Factor V Cambridge. A new mutation associated with resistance to activated protein C. Blood 1998; 91: 1140-4.
    PubMedGoogle Scholar
  • 5 Franco RF, Maffei FH, Lourenco D, Morelli V, Thomazini IA, Piccinato CE, Tavella MH, Zago MA. Factor V Arg306→Thr (Factor V Cambridge) and Factor V Arg->306 Gly mutations in venous thrombotic disease. Br J Haematol 1998; 103: 888-90.
    CrossrefPubMedGoogle Scholar
  • 6 Ames PRJ, Catello T, Iannaccone L, Brillante M, Cimino R, Brancaccio V. Coagulation activation and fibrinolytic imbalance in subjects with idiopathic antiphospholipid antibodies. A crucial role for acquired free protein S deficiency. Thromb Haemost 1996; 76: 190-4.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 7 Koeleman BPC, Reitsma PH, Allart CF, Bertina RM. Activated protein C resistance as an additional risk factor for thrombosis in protein C-deficient families. Blood 1994; 84: 1031-5.
    PubMedGoogle Scholar
  • 8 Margaglione M, D’Andrea G, Grandone E, Brancaccio V, Amoriello A, Di Minno G. Compound heterozygosity (554-589 del, C515-T transition) in the platelet glycoprotein Ib( gene in a patient with a severe bleeding tendency. Thromb Haemost 1999; 81: 486-92.
    Article in Thieme ConnectPubMedGoogle Scholar