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Thromb Haemost 2003; 90(05): 766-767
DOI: 10.1055/s-0037-1613493
Editorial Focus
Schattauer GmbH

Insertion/deletion polymorphism of the angiotensin-converting enzyme gene: really a risk factor for venous thromboembolism?

Gülfer Okumus
1   Department of Pulmonary Diseases, Istanbul University, Istanbul Medical Faculty, Istanbul, Turkey
,
Orhan Arseven
1   Department of Pulmonary Diseases, Istanbul University, Istanbul Medical Faculty, Istanbul, Turkey
› Author Affiliations
Further Information

Publication History

Received 26 August 2003

Accepted after revision 08 September 2003

Publication Date:
06 December 2017 (online)

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  • References

  • 1 De Stefano V, Rossi E, Paciaroni K. et al Screening for inherited thrombophilia: Indications and therapeutic implications. Haematologica 2002; 87: 1095-8.
    PubMedGoogle Scholar
  • 2 Dzau V. Cell biology and genetics of angiotensin in cardiovascular disease. J Hyper 1994; 12: 3-10.
    PubMedGoogle Scholar
  • 3 Rigat N, Hubert C, Alhenc-Gelas F. et al An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 1990; 86: 1343-6.
    CrossrefPubMedGoogle Scholar
  • 4 Winkelmann BR, Nauck M, Klein B. et al Deletion polymorphism of the angiotensin I-converting enzyme activity but not with increased risk for myocardial infarction and coronary artery disease. Ann Intern Med 1996; 125: 19-25.
    CrossrefPubMedGoogle Scholar
  • 5 Cambien F, Poirier O, Lecerf L. et al Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction. Nature 1992; 359: 641-4.
    CrossrefPubMedGoogle Scholar
  • 6 Holmer SR, Bickeboller H, Hengstenberg C. et al Angiotensin Converting enzyme gene polymorphism and myocardial infarction a large association and linkage study. Int J Biochem Cell Biol 2003; 35: 955-62.
    CrossrefPubMedGoogle Scholar
  • 7 Dilley A, Austin H, Hooper WC. et al Relation of three genetic traits to venous thrombosis in an African-American population. Am J Epidemiol 1998; 147: 30-5.
    CrossrefPubMedGoogle Scholar
  • 8 Jackson A, Brown K, Langdown J. et al Effect of the angiotensin-converting enzyme gene deletion polymorphism on the risk of venous thromboembolism. Br J Haematol 2000; 111: 562-4.
    CrossrefPubMedGoogle Scholar
  • 9 Gonzales Ordonez AJ, Fernandez Carreira JM. et al Risk of venous thromboembolism associated with the insertion/deletion polymorphism in the angiotensin converting enzyme gene. Blood Coagul Fibrinolysis 2000; 11: 485-90.
    CrossrefPubMedGoogle Scholar
  • 10 Philipp CS, Dilley A, Saidi P. et al Deletion polymorphism in the angiotensin-converting enzyme gene as a thrombophilic risk factor after hip arthroplasty. Thromb Haemost 1998; 80: 869-73.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 11 Lu Y, Hui R, Zhao Y. Insertion/deletion poly-morphism of the angiotensin I converting enzyme gene and pulmonary thromboembolism in Chinese population. Zhonghua Jie He He HU Xi Za Zhi 2001; 24: 265-8.
    PubMedGoogle Scholar
  • 12 Von Depka M, Czwalinna A, Wermes C. et al. The deletion polymorphism in the angiotensin-converting enzyme gene is a moderate risk factor for venous thromboembolism. Thromb Haemost 2003; 89: 847-52.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 13 Wells PS, Rodger MA, Forgie MA. et al The ACE D/D genotype is protective against the development of idiopathic deep vein thrombosis and pulmonary embolism. Thromb Haemost 2003; 90: 829-34.
    Article in Thieme ConnectPubMedGoogle Scholar