Circulating Procoagulant Microparticles in Women with Unexplained Pregnancy Loss: a New Insight

I. Laude; C. Rongières-Bertrand; C. Boyer-Neumann; M. Wolf; V. Mairovitz; B. Hugel; J. M. Freyssinet; R. Frydman; D. Meyer; V. Eschwège

doi:10.1055/s-0037-1612657

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2001; 85(01): 18-21
DOI: 10.1055/s-0037-1612657

Rapid Communications

Schattauer GmbH

Circulating Procoagulant Microparticles in Women with Unexplained Pregnancy Loss: a New Insight

Autoren

I. Laude

¹Unité 143 Institut National de la Santé et de la Recherche Médicale, Hôpital de Bicêtre, Le Kremlin-Bicêtre
C. Rongières-Bertrand

³Service de Gynécologie-Obstétrique, Hôpital Antoine-Béclère, AP-HP, Clamart
C. Boyer-Neumann

¹Unité 143 Institut National de la Santé et de la Recherche Médicale, Hôpital de Bicêtre, Le Kremlin-Bicêtre

²Service d’Hématologie Biologique
M. Wolf

¹Unité 143 Institut National de la Santé et de la Recherche Médicale, Hôpital de Bicêtre, Le Kremlin-Bicêtre

²Service d’Hématologie Biologique
V. Mairovitz

³Service de Gynécologie-Obstétrique, Hôpital Antoine-Béclère, AP-HP, Clamart
B. Hugel

¹Unité 143 Institut National de la Santé et de la Recherche Médicale, Hôpital de Bicêtre, Le Kremlin-Bicêtre

²Service d’Hématologie Biologique
J. M. Freyssinet

¹Unité 143 Institut National de la Santé et de la Recherche Médicale, Hôpital de Bicêtre, Le Kremlin-Bicêtre

⁴Institut d’Hématologie et d’Immunologie, Faculté de Médecine, Strasbourg, France
R. Frydman

³Service de Gynécologie-Obstétrique, Hôpital Antoine-Béclère, AP-HP, Clamart
D. Meyer

¹Unité 143 Institut National de la Santé et de la Recherche Médicale, Hôpital de Bicêtre, Le Kremlin-Bicêtre

²Service d’Hématologie Biologique
V. Eschwège

¹Unité 143 Institut National de la Santé et de la Recherche Médicale, Hôpital de Bicêtre, Le Kremlin-Bicêtre

Abstract

Summary

One of the frequently proposed mechanisms for pregnancy losses refers to uteroplacental thrombosis. However the contribution of classical thrombotic risk factors remains questionable and, if real, does not account for a large number of pregnancy losses. The aim of this study was to investigate the presence of circulating procoagulant microparticles, a new marker of cell activation already associated with various prothrombotic clinical settings. Microparticles were assessed by an original prothrombinase assay on platelet depleted plasma obtained from 74 women with a history of pregnancy loss without apparent cause and 50 controls. Patients were studied at least 2 months after the last obstetrical event and were classified into 2 groups: 49 women with at least 3 consecutive spontaneous abortions at or before the 10th postmenstrual week and 25 with at least one fetal death beyond the 10th postmenstrual week. Among the 74 patients, 41 had increased levels of circulating microparticles, 29 belonging to the group of early pregnancy loss (59%) and 12 to the group of late pregnancy loss (48%). The high prevalence of increased levels of procoagulant microparticles in both groups makes this new marker very promising for the understanding, follow up and therapeutical handling of pregnancy loss.

Keywords

Microparticles - unexplained pregnancy loss

Volltext

Referenzen

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