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Synthesis 2019; 51(06): 1455-1465
DOI: 10.1055/s-0037-1611354
DOI: 10.1055/s-0037-1611354
paper
Palladium-Catalyzed Synthesis of β,β-Diaryl α,β-Unsaturated Ketones
Financial support from the National Natural Science Foundation of China (No. 81473076 and 81673292), the National Basic Research Program of China (973 Program, 2015CB931804), and the Science and Technology Commission of Shanghai Municipality (No. 15431900100) is gratefully acknowledged.Further Information
Publication History
Received: 27 July 2018
Accepted after revision: 23 October 2018
Publication Date:
03 December 2018 (online)
Abstract
We herein describe a versatile palladium-catalyzed synthesis of β,β-diaryl α,β-unsaturated ketones. A broad range of aryl halides react with β-arylbutanones to afford biologically useful, symmetrical and unsymmetrical ketones. The use of 4,5-diazafluoren-9-one and oxygen makes this one-pot reaction more applicable. A plausible mechanism involving palladium-catalyzed oxidative Heck-type cross-coupling is also proposed.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1611354.
- Supporting Information
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