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Synthesis 2018; 50(11): 2221-2230
DOI: 10.1055/s-0037-1609345
DOI: 10.1055/s-0037-1609345
paper
An Aniline-Mediated Regioselective Synthesis of Quinoxalin-2-ones via the Condensation of α-Ketimine Esters with 2-Aminoanilines
Further Information
Publication History
Received: 15 January 2018
Accepted after revision: 18 February 2018
Publication Date:
03 April 2018 (online)
Abstract
A highly regioselective method for the condensation of α-ketimine esters with 2-aminoanilines for the construction of quinoxalin-2-one derivatives is described. The substrate scope with 2-aminoaniline derivatives and different α-keto esters is explored with yields ranging from 44 to 90% and typical isolated regioselectivities between 6.4 to >25:1.
Key words
quinoxalin-2-ones - 2-aminoanilines - α-ketimine esters - one-pot synthesis - transimination - regioselectivitySupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1609345.
- Supporting Information
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