Digestive Disease Interventions 2017; 01(03): 201-207
DOI: 10.1055/s-0037-1606630
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Contrast-Enhanced Ultrasound for Guidance of Percutaneous Liver Interventions in Neoplastic Hepatic Disease

Rivka Kessner
1   Center of Interventional Radiology, Department of Radiology, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio
,
Sasan Partovi
1   Center of Interventional Radiology, Department of Radiology, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio
,
Dean Nakamoto
1   Center of Interventional Radiology, Department of Radiology, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio
,
Ziang Lu
1   Center of Interventional Radiology, Department of Radiology, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio
,
Alice Yu
1   Center of Interventional Radiology, Department of Radiology, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio
,
Indravadan J. Patel
1   Center of Interventional Radiology, Department of Radiology, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio
,
Yasmine Ahmed
1   Center of Interventional Radiology, Department of Radiology, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio
,
Nami Azar
1   Center of Interventional Radiology, Department of Radiology, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio
› Author Affiliations
Further Information

Publication History

04 August 2017

11 August 2017

Publication Date:
25 September 2017 (online)

Abstract

Contrast-enhanced ultrasound (CEUS) is an evolving technique for the detection and characterization of focal liver lesions. Currently, it is recommended mainly for inconclusive cases and for patients with contraindications to computed tomography (CT)/magnetic resonance imaging. For percutaneous liver interventions, image guidance is of utmost importance to detect the target lesion. Primarily, ultrasound guidance is used for liver biopsies and ablations. CT is reserved for challenging cases, for example, when the target or the surrounding structures are not well identified with standard B-mode ultrasound. Instead of CT guidance, CEUS has gained increasing interest for percutaneous liver interventions. CEUS has the advantage of superior target visualization, real-time imaging guidance of probe or needle advancement without exposure to radiation.

 
  • References

  • 1 Chaubal N, Joshi M, Bam A, Chaubal R. Contrast-enhanced ultrasound of focal liver lesions. Semin Roentgenol 2016; 51 (04) 334-357
  • 2 Salvatore V, Bolondi L. Clinical impact of ultrasound-related techniques on the diagnosis of focal liver lesions. Liver Cancer 2012; 1 (3-4): 238-246
  • 3 Claudon M, Dietrich CF, Choi BI. , et al; World Federation for Ultrasound in Medicine; European Federation of Societies for Ultrasound. Guidelines and good clinical practice recommendations for Contrast Enhanced Ultrasound (CEUS) in the liver-update 2012: A WFUMB-EFSUMB initiative in cooperation with representatives of AFSUMB, AIUM, ASUM, FLAUS and ICUS. Ultrasound Med Biol 2013; 39 (02) 187-210
  • 4 Maruyama H, Sekimoto T, Yokosuka O. Role of contrast-enhanced ultrasonography with Sonazoid for hepatocellular carcinoma: evidence from a 10-year experience. J Gastroenterol 2016; 51 (05) 421-433
  • 5 Blomley M, Claudon M, Cosgrove D. WFUMB Safety Symposium on Ultrasound Contrast Agents: clinical applications and safety concerns. Ultrasound Med Biol 2007; 33 (02) 180-186
  • 6 Chung YE, Kim KW. Contrast-enhanced ultrasonography: advance and current status in abdominal imaging. Ultrasonography 2015; 34 (01) 3-18
  • 7 Torres A, Koskinen SK, Gjertsen H, Fischler B. Contrast-enhanced ultrasound using sulfur hexafluoride is safe in the pediatric setting. Acta Radiol 2017; (e-pub ahead of print) DOI: 284185117690423.
  • 8 D'Onofrio M, Crosara S, De Robertis R, Canestrini S, Mucelli RP. Contrast-enhanced ultrasound of focal liver lesions. AJR Am J Roentgenol 2015; 205 (01) W56-W66
  • 9 Bartolotta TV, Taibbi A, Picone D, Anastasi A, Midiri M, Lagalla R. Detection of liver metastases in cancer patients with geographic fatty infiltration of the liver: the added value of contrast-enhanced sonography. Ultrasonography 2017; 36 (02) 160-169
  • 10 Cantisani V, Grazhdani H, Fioravanti C. , et al. Liver metastases: Contrast-enhanced ultrasound compared with computed tomography and magnetic resonance. World J Gastroenterol 2014; 20 (29) 9998-10007
  • 11 Friedrich-Rust M, Klopffleisch T, Nierhoff J. , et al. Contrast-enhanced ultrasound for the differentiation of benign and malignant focal liver lesions: a meta-analysis. Liver Int 2013; 33 (05) 739-755
  • 12 Sporea I, Badea R, Popescu A. , et al. Contrast-enhanced ultrasound (CEUS) for the evaluation of focal liver lesions-a prospective multicenter study of its usefulness in clinical practice. Ultraschall Med 2014; 35 (03) 259-266
  • 13 Strobel D, Bernatik T, Blank W. , et al. Diagnostic accuracy of CEUS in the differential diagnosis of small (≤20 mm) and subcentimetric (≤10 mm) focal liver lesions in comparison with histology. Results of the DEGUM multicenter trial. Ultraschall Med 2011; 32 (06) 593-597
  • 14 Pang EH, Harris AC, Chang SD. Approach to the solitary liver lesion: imaging and when to biopsy. Can Assoc Radiol J 2016; 67 (02) 130-148
  • 15 Rossi P, Sileri P, Gentileschi P. , et al. Percutaneous liver biopsy using an ultrasound-guided subcostal route. Dig Dis Sci 2001; 46 (01) 128-132
  • 16 Spârchez Z, Radu P, Zaharia T, Kacso G, Grigorescu I, Badea R. Contrast enhanced ultrasound guidance: a new tool to improve accuracy in percutaneous biopsies. Med Ultrason 2010; 12 (02) 133-138
  • 17 Schlottmann K, Klebl F, Zorger N, Feuerbach S, Schölmerich J. Contrast-enhanced ultrasound allows for interventions of hepatic lesions which are invisible on conventional B-mode. Z Gastroenterol 2004; 42 (04) 303-310
  • 18 Wu W, Chen MH, Yin SS. , et al. The role of contrast-enhanced sonography of focal liver lesions before percutaneous biopsy. AJR Am J Roentgenol 2006; 187 (03) 752-761
  • 19 Yoon SH, Lee KH, Kim SY. , et al. Real-time contrast-enhanced ultrasound-guided biopsy of focal hepatic lesions not localised on B-mode ultrasound. Eur Radiol 2010; 20 (08) 2047-2056
  • 20 Spârchez Z, Radu P, Kacso G, Spârchez M, Zaharia T, Al Hajjar N. Prospective comparison between real time contrast enhanced and conventional ultrasound guidance in percutaneous biopsies of liver tumors. Med Ultrason 2015; 17 (04) 456-463
  • 21 Sparchez Z, Radu P, Zaharia T. , et al. Usefulness of contrast enhanced ultrasound guidance in percutaneous biopsies of liver tumors. J Gastrointestin Liver Dis 2011; 20 (02) 191-196
  • 22 Thandassery RB, Goenka U, Goenka MK. Role of local ablative therapy for hepatocellular carcinoma. J Clin Exp Hepatol 2014; 4 (Suppl. 03) S104-S111
  • 23 Minami Y, Kudo M. Review of dynamic contrast-enhanced ultrasound guidance in ablation therapy for hepatocellular carcinoma. World J Gastroenterol 2011; 17 (45) 4952-4959
  • 24 Simon CJ, Dupuy DE, Mayo-Smith WW. Microwave ablation: principles and applications. Radiographics 2005; 25 (Suppl. 01) S69-S83
  • 25 Liang P, Wang Y. Microwave ablation of hepatocellular carcinoma. Oncology 2007; 72 (Suppl. 01) 124-131
  • 26 Carrafiello G, Laganà D, Mangini M. , et al. Microwave tumors ablation: principles, clinical applications and review of preliminary experiences. Int J Surg 2008; 6 (Suppl. 01) S65-S69
  • 27 Wright AS, Sampson LA, Warner TF, Mahvi DM, Lee Jr FT. Radiofrequency versus microwave ablation in a hepatic porcine model. Radiology 2005; 236 (01) 132-139
  • 28 Vogl TJ, Farshid P, Naguib NN. , et al. Ablation therapy of hepatocellular carcinoma: a comparative study between radiofrequency and microwave ablation. Abdom Imaging 2015; 40 (06) 1829-1837
  • 29 Potretzke TA, Ziemlewicz TJ, Hinshaw JL. , et al. Microwave versus radiofrequency ablation treatment for hepatocellular carcinoma: a comparison of efficacy at a single center. J Vasc Interv Radiol 2016; 27 (05) 631-638
  • 30 Lucchina N, Tsetis D, Ierardi AM. , et al. Current role of microwave ablation in the treatment of small hepatocellular carcinomas. Ann Gastroenterol 2016; 29 (04) 460-465
  • 31 Masuzaki R, Shiina S, Tateishi R. , et al. Utility of contrast-enhanced ultrasonography with Sonazoid in radiofrequency ablation for hepatocellular carcinoma. J Gastroenterol Hepatol 2011; 26 (04) 759-764
  • 32 Minami Y, Kudo M, Kawasaki T, Chung H, Ogawa C, Shiozaki H. Treatment of hepatocellular carcinoma with percutaneous radiofrequency ablation: usefulness of contrast harmonic sonography for lesions poorly defined with B-mode sonography. AJR Am J Roentgenol 2004; 183 (01) 153-156
  • 33 Chan AK, Hegarty C, Klass D. , et al. The role of contrast-enhanced ultrasound in guiding radiofrequency ablation of hepatocellular carcinoma: a retrospective study. Can Assoc Radiol J 2015; 66 (02) 171-178
  • 34 Liu F, Yu X, Liang P, Cheng Z, Han Z, Dong B. Contrast-enhanced ultrasound-guided microwave ablation for hepatocellular carcinoma inconspicuous on conventional ultrasound. Int J Hyperthermia 2011; 27 (06) 555-562
  • 35 Lorentzen T, Skjoldbye BO, Nolsoe CP. Microwave ablation of liver metastases guided by contrast-enhanced ultrasound: experience with 125 metastases in 39 patients. Ultraschall Med 2011; 32 (05) 492-496
  • 36 Yan SY, Zhang Y, Sun C. , et al. Comparison of real-time contrast-enhanced ultrasonography and standard ultrasonography in liver cancer microwave ablation. Exp Ther Med 2016; 12 (03) 1345-1348
  • 37 Meloni MF, Andreano A, Franza E, Passamonti M, Lazzaroni S. Contrast enhanced ultrasound: Should it play a role in immediate evaluation of liver tumors following thermal ablation?. Eur J Radiol 2012; 81 (08) e897-e902
  • 38 Qu P, Yu X, Liang P. , et al. Contrast-enhanced ultrasound in the characterization of hepatocellular carcinomas treated by ablation: comparison with contrast-enhanced magnetic resonance imaging. Ultrasound Med Biol 2013; 39 (09) 1571-1579