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Neuropediatrics 2017; 48(05): 329-339
DOI: 10.1055/s-0037-1601322
Review Article
Georg Thieme Verlag KG Stuttgart · New York

The Cerebellum and Its Wrapping Meninge: Developmental Interplay between Two Major Structures

Martin Catala
1   Laboratoire de Biologie du Développement, CNRS and Université Pierre et Marie Curie (UPMC), Paris, France
2   Fédération de Neurologie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France
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Publication History

23 December 2016

21 February 2017

Publication Date:
23 March 2017 (online)

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Abstract

Meninges have long been considered as a protective and supportive tissue for the central nervous system. Nevertheless, new developmental roles are now attributed to them. The meninges that surround the cerebellum come from the cephalic mesoderm. They are essential for the cerebellum to develop normally. They induce and maintain the basal lamina and glia limitans. In the absence of these structures, the external granular cells of the cerebellum migrate aberrantly and penetrate the subarachnoid space. The molecules involved in the recognition between the cerebellar primordium and the basal lamina belong to two groups in humans: dystroglycan and laminin on the one hand, and GPR56 and collagen III on the other. Finally, molecules secreted by the meninges and acting on the cerebellum begin to be demonstrated; such is the case of SDF1 secreted under the action of FOXC1.

Keywords

developmental biology - cell interaction - genes - cerebellar polymicrogyria
 

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