Semin Thromb Hemost 2017; 43(04): 397-406
DOI: 10.1055/s-0037-1599158
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Experience of Point-of-Care Devices in Obstetrical Care

Ove Karlsson
1   Department of Anesthesiology, Sahlgrenska University Hospital, Gothenburg, Sweden
› Author Affiliations
Further Information

Publication History

Publication Date:
29 March 2017 (online)

Abstract

During pregnancy and puerperium, there are pronounced hemostatic changes characterized by increased coagulability and decreased fibrinolysis. In addition, hemostasis can change dramatically during obstetric complications. Several reports have described substandard management of hemostatic defects in this setting and state the need for guidelines and better care. Point-of-care devices can assess hemostatic status and are especially suitable in perioperative settings. Using point-of-care devices, no time is required for transportation, allowing faster availability of results and providing potential for better care of the patient. This article will demonstrate the use of a viscoelastic method in six different patients; five with impaired hemostasis, and where the use of viscoelastic method contributes or should have contributed to better care. The cases represent patients with normal delivery; postpartum hemorrhage (PPH); PPH with low fibrinogen; placental abruption; preeclampsia with hemolysis, elevated liver enzymes, low platelet count syndrome; and finally, one patient with sepsis. This article also shows the need for good practices and good supervision to implement the devices in patient care.

 
  • References

  • 1 Hellgren M. Hemostasis during normal pregnancy and puerperium. Semin Thromb Hemost 2003; 29 (02) 125-130
  • 2 Bremme KA. Haemostatic changes in pregnancy. Best Pract Res Clin Haematol 2003; 16 (02) 153-168
  • 3 Karlsson O, Sporrong T, Hillarp A, Jeppsson A, Hellgren M. Prospective longitudinal study of thromboelastography and standard hemostatic laboratory tests in healthy women during normal pregnancy. Anesth Analg 2012; 115 (04) 890-898
  • 4 Karlsson O, Jeppsson A, Hellgren M. A longitudinal study of factor XIII activity, fibrinogen concentration, platelet count and clot strength during normal pregnancy. Thromb Res 2014; 134 (03) 750-752
  • 5 Huissoud C, Carrabin N, Benchaib M. , et al. Coagulation assessment by rotation thrombelastometry in normal pregnancy. Thromb Haemost 2009; 101 (04) 755-761
  • 6 Huissoud C, Carrabin N, Audibert F. , et al. Bedside assessment of fibrinogen level in postpartum haemorrhage by thrombelastometry. BJOG 2009; 116 (08) 1097-1102
  • 7 Karlsson O, Jeppsson A, Hellgren M. Major obstetric haemorrhage: monitoring with thromboelastography, laboratory analyses or both?. Int J Obstet Anesth 2014; 23 (01) 10-17
  • 8 Levi M, Poll Tv. Coagulation in patients with severe sepsis. Semin Thromb Hemost 2015; 41 (01) 9-15
  • 9 Harnett MJ, Hepner DL, Datta S, Kodali BS. Effect of amniotic fluid on coagulation and platelet function in pregnancy: an evaluation using thromboelastography. Anaesthesia 2005; 60 (11) 1068-1072
  • 10 Mea K. Saving Lives, Improving Mothers' Care. MBRRACE-UK; 2014
  • 11 Cantwell R, Clutton-Brock T, Cooper G. , et al. Saving Mothers' Lives: reviewing maternal deaths to make motherhood safer: 2006-2008. The Eighth Report of the Confidential Enquiries into Maternal Deaths in the United Kingdom. BJOG 2011; 118 (Suppl. 01) 1-203
  • 12 Butwick A, Carvalho B. The effect of colloid and crystalloid preloading on thromboelastography prior to cesarean delivery. Can J Anaesth 2007; 54 (03) 190-195
  • 13 Erez O, Mastrolia SA, Thachil J. Disseminated intravascular coagulation in pregnancy: insights in pathophysiology, diagnosis and management. Am J Obstet Gynecol 2015; 213 (04) 452-463
  • 14 Luddington RJ. Thrombelastography/thromboelastometry. Clin Lab Haematol 2005; 27 (02) 81-90
  • 15 Ganter MT, Hofer CK. Coagulation monitoring: current techniques and clinical use of viscoelastic point-of-care coagulation devices. Anesth Analg 2008; 106 (05) 1366-1375
  • 16 Lancé MD. A general review of major global coagulation assays: thrombelastography, thrombin generation test and clot waveform analysis. Thromb J 2015; 13: 1
  • 17 Winstedt D, Tynngård N, Olanders K, Schött U. Free oscillation rheometry monitoring of haemodilution and hypothermia and correction with fibrinogen and factor XIII concentrates. Scand J Trauma Resusc Emerg Med 2013; 21: 20
  • 18 de Lange NM, van Rheenen-Flach LE, Lancé MD. , et al. Peri-partum reference ranges for ROTEM(R) thromboelastometry. Br J Anaesth 2014; 112 (05) 852-859
  • 19 Afshari A, Wikkelsø A, Brok J, Møller AM, Wetterslev J. Thrombelastography (TEG) or thromboelastometry (ROTEM) to monitor haemotherapy versus usual care in patients with massive transfusion. Cochrane Database Syst Rev 2011; (03) CD007871
  • 20 Levi M, Hunt BJ. A critical appraisal of point-of-care coagulation testing in critically ill patients. J Thromb Haemost 2015; 13 (11) 1960-1967
  • 21 Rossaint R, Bouillon B, Cerny V. , et al. The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition. Crit Care 2016; 20: 100
  • 22 Mallett SV, Armstrong M. Point-of-care monitoring of haemostasis. Anaesthesia 2015; 70 (01) (Suppl. 01) 73-77 , e25–e26
  • 23 Teofili L, Bianchi M, Zanfini BA. , et al. Acute lung injury complicating blood transfusion in post-partum hemorrhage: incidence and risk factors. Mediterr J Hematol Infect Dis 2014; 6 (01) e2014069
  • 24 Michala L, Madhavan B, Win N, De Lord C, Brown R. Transfusion-related acute lung injury (TRALI) in an obstetric patient. Int J Obstet Anesth 2008; 17 (01) 66-69
  • 25 Theusinger OM, Stein P, Levy JH. Point of care and factor concentrate-based coagulation algorithms. Transfus Med Hemother 2015; 42 (02) 115-121
  • 26 Murphy GJ, Reeves BC, Rogers CA, Rizvi SI, Culliford L, Angelini GD. Increased mortality, postoperative morbidity, and cost after red blood cell transfusion in patients having cardiac surgery. Circulation 2007; 116 (22) 2544-2552
  • 27 Romlin BS, Wåhlander H, Berggren H. , et al. Intraoperative thromboelastometry is associated with reduced transfusion prevalence in pediatric cardiac surgery. Anesth Analg 2011; 112 (01) 30-36
  • 28 Wang G, Xie G, Jiang T. , et al. Tranexamic acid reduces blood loss after off-pump coronary surgery: a prospective, randomized, double-blind, placebo-controlled study. Anesth Analg 2012; 115 (02) 239-243
  • 29 Yamamoto K, Usui A, Takamatsu J. Fibrinogen concentrate administration attributes to significant reductions of blood loss and transfusion requirements in thoracic aneurysm repair. J Cardiothorac Surg 2014; 9: 90
  • 30 Spahn DR, Bouillon B, Cerny V. , et al. Management of bleeding and coagulopathy following major trauma: an updated European guideline. Crit Care 2013; 17 (02) R76
  • 31 Ponschab M, Schöchl H, Keibl C, Fischer H, Redl H, Schlimp CJ. Preferential effects of low volume versus high volume replacement with crystalloid fluid in a hemorrhagic shock model in pigs. BMC Anesthesiol 2015; 15: 133
  • 32 White NJ, Martin EJ, Brophy DF, Ward KR. Coagulopathy and traumatic shock: characterizing hemostatic function during the critical period prior to fluid resuscitation. Resuscitation 2010; 81 (01) 111-116
  • 33 Ekelund K, Hanke G, Stensballe J, Wikkelsøe A, Albrechtsen CK, Afshari A. Hemostatic resuscitation in postpartum hemorrhage - a supplement to surgery. Acta Obstet Gynecol Scand 2015; 94 (07) 680-692
  • 34 Kozek-Langenecker SA, Afshari A, Albaladejo P. , et al. Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology. Eur J Anaesthesiol 2013; 30 (06) 270-382
  • 35 Mallaiah S, Barclay P, Harrod I, Chevannes C, Bhalla A. Introduction of an algorithm for ROTEM-guided fibrinogen concentrate administration in major obstetric haemorrhage. Anaesthesia 2015; 70 (02) 166-175
  • 36 Simonazzi G, Bisulli M, Saccone G, Moro E, Marshall A, Berghella V. Tranexamic acid for preventing postpartum blood loss after cesarean delivery: a systematic review and meta-analysis of randomized controlled trials. Acta Obstet Gynecol Scand 2016; 95 (01) 28-37
  • 37 de Lange NM, Lancé MD, de Groot R, Beckers EA, Henskens YM, Scheepers HC. Obstetric hemorrhage and coagulation: an update. Thromboelastography, thromboelastometry, and conventional coagulation tests in the diagnosis and prediction of postpartum hemorrhage. Obstet Gynecol Surv 2012; 67 (07) 426-435
  • 38 Solomon C, Collis RE, Collins PW. Haemostatic monitoring during postpartum haemorrhage and implications for management. Br J Anaesth 2012; 109 (06) 851-863
  • 39 Butwick AJ, Goodnough LT. Transfusion and coagulation management in major obstetric hemorrhage. Curr Opin Anaesthesiol 2015; 28 (03) 275-284
  • 40 Girard T, Mörtl M, Schlembach D. New approaches to obstetric hemorrhage: the postpartum hemorrhage consensus algorithm. Curr Opin Anaesthesiol 2014; 27 (03) 267-274