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J Pediatr Infect Dis 2016; 11(03): 86-92
DOI: 10.1055/s-0036-1597304
Review Article
Georg Thieme Verlag KG Stuttgart · New York

Infectious Complications of Chronic Kidney Disease in the Developing World

Priya Pais
1   Department of Pediatric Nephrology, St John's Medical College Hospital, St John's National Academy of Health Sciences, Bangalore, India
› Author Affiliations
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Publication History

18 July 2016

19 September 2016

Publication Date:
14 December 2016 (online)

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Abstract

This review focuses on infections of pediatric chronic kidney disease (CKD) in the developing world. Published data on the epidemiology of infections occurring in children with CKD, specifically in low-income countries, are very limited. The infections discussed here are therefore a combination of those known to occur frequently in CKD in addition to those that commonly occur in children in developing countries. The latter include infections commonly seen in the author's clinical practice of CKD in a developing nation. This practice is a tertiary care center for pediatric nephrology in South India, one of the very few stand-alone pediatric nephrology departments providing CKD care including dialysis and transplantation in a developing nation. PubMed was searched for relevant articles using the following keywords: “CKD,” “dialysis” “infection,” “child” in addition to the keywords for each specific infection discussed here. In addition, where relevant, World Health Organization data and statistics were referred to for infections that are highly prevalent in developing nations.

Keywords

CKD - child - infection - dialysis - tuberculosis
 

  • References

  • 1 UNDP. Human Development Report. 2015 . Available at: http://hdr.undp.org/en/data . Accessed on December 7, 2016
    PubMedGoogle Scholar
  • 2 Children: Reducing Mortality. http://www.who.int/mediacentre/factsheets/fs178/en/ . Accessed on December 7, 2016
    Google Scholar
  • 3 Garcia-Garcia G, Jha V. ; World Kidney Day Steering Committee. CKD in disadvantaged populations. Kidney Int 2015; 87 (02) 251-253
    CrossrefPubMedGoogle Scholar
  • 4 Hill NR, Fatoba ST, Oke JL. , et al. Global prevalence of chronic kidney disease - a systematic review and meta-analysis. PLoS One 2016; 11 (07) e0158765
    CrossrefPubMedGoogle Scholar
  • 5 Harambat J, van Stralen KJ, Kim JJ, Tizard EJ. Epidemiology of chronic kidney disease in children. Pediatr Nephrol 2012; 27 (03) 363-373
    CrossrefPubMedGoogle Scholar
  • 6 Sinha A, Bagga A. Maintenance dialysis in developing countries. Pediatr Nephrol 2015; 30 (02) 211-219
    CrossrefPubMedGoogle Scholar
  • 7 Warady BA, Chadha V. Chronic kidney disease in children: the global perspective. Pediatr Nephrol 2007; 22 (12) 1999-2009
    CrossrefPubMedGoogle Scholar
  • 8 Karopadi AN, Mason G, Rettore E, Ronco C. Cost of peritoneal dialysis and haemodialysis across the world. Nephrol Dial Transplant 2013; 28 (10) 2553-2569
    CrossrefPubMedGoogle Scholar
  • 9 Schaefer F, Borzych-Duzalka D, Azocar M. , et al; IPPN investigators. Impact of global economic disparities on practices and outcomes of chronic peritoneal dialysis in children: insights from the International Pediatric Peritoneal Dialysis Network Registry. Perit Dial Int 2012; 32 (04) 399-409
    CrossrefPubMedGoogle Scholar
  • 10 Ardissino G, Daccò V, Testa S. , et al; ItalKid Project. Epidemiology of chronic renal failure in children: data from the ItalKid project. Pediatrics 2003; 111 4 Pt 1 e382-e387
    CrossrefPubMedGoogle Scholar
  • 11 Kato S, Chmielewski M, Honda H. , et al. Aspects of immune dysfunction in end-stage renal disease. Clin J Am Soc Nephrol 2008; 3 (05) 1526-1533
    CrossrefPubMedGoogle Scholar
  • 12 Mak RH, Cheung WW, Zhan JY, Shen Q, Foster BJ. Cachexia and protein-energy wasting in children with chronic kidney disease. Pediatr Nephrol 2012; 27 (02) 173-181
    CrossrefPubMedGoogle Scholar
  • 13 Katona P, Katona-Apte J. The interaction between nutrition and infection. Clin Infect Dis 2008; 46 (10) 1582-1588
    CrossrefPubMedGoogle Scholar
  • 14 UNICEF. UNICEF Data: Monitoring the Situation of Children and Women. 2016 . Available at: http://data.unicef.org/nutrition/malnutrition.html . Accessed on December 7, 2016
    PubMedGoogle Scholar
  • 15 World Health Organization. Diarrhoeal Disease. 2013 . Available at: http://www.who.int/mediacentre/factsheets/fs330/en/ . Accessed July 2016
    PubMedGoogle Scholar
  • 16 Kotloff KL, Nataro JP, Blackwelder WC. , et al. Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study. Lancet 2013; 382 9888 209-222
    CrossrefPubMedGoogle Scholar
  • 17 Roncal-Jimenez C, Lanaspa MA, Jensen T, Sanchez-Lozada LG, Johnson RJ. Mechanisms by Which Dehydration May Lead to Chronic Kidney Disease. Ann Nutr Metab 2015; 66 (Suppl. 03) 10-13
    PubMedGoogle Scholar
  • 18 Rudan I, O'Brien KL, Nair H. , et al; Child Health Epidemiology Reference Group (CHERG). Epidemiology and etiology of childhood pneumonia in 2010: estimates of incidence, severe morbidity, mortality, underlying risk factors and causative pathogens for 192 countries. J Glob Health 2013; 3 (01) 010401
    PubMedGoogle Scholar
  • 19 Neu AM. Immunizations in children with chronic kidney disease. Pediatr Nephrol 2012; 27 (08) 1257-1263
    CrossrefPubMedGoogle Scholar
  • 20 World Health Organization. Tuberculosis Fact Sheet. 2016 . Available at: http://www.who.int/mediacentre/factsheets/fs104/en/ . Accessed July 2016
    PubMedGoogle Scholar
  • 21 Romanowski K, Clark EG, Levin A, Cook VJ, Johnston JC. Tuberculosis and chronic kidney disease: an emerging global syndemic. Kidney Int 2016; 90 (01) 34-40
    CrossrefPubMedGoogle Scholar
  • 22 Al-Efraij K, Mota L, Lunny C, Schachter M, Cook V, Johnston J. Risk of active tuberculosis in chronic kidney disease: a systematic review and meta-analysis. Int J Tuberc Lung Dis 2015; 19 (12) 1493-1499
    CrossrefPubMedGoogle Scholar
  • 23 Segall L, Covic A. Diagnosis of tuberculosis in dialysis patients: current strategy. Clin J Am Soc Nephrol 2010; 5 (06) 1114-1122
    CrossrefPubMedGoogle Scholar
  • 24 World Health Organization. Guidance for National Tuberculosis Programmes on the Management of Tuberculosis in Children. 2014. Available at: http://www.who.int/tb/publications/childtb_guidelines/en/ . Accessed 2016
    PubMedGoogle Scholar
  • 25 Woeltje KF, Mathew A, Rothstein M, Seiler S, Fraser VJ. Tuberculosis infection and anergy in hemodialysis patients. Am J Kidney Dis 1998; 31 (05) 848-852
    CrossrefPubMedGoogle Scholar
  • 26 Sester M, van Leth F, Bruchfeld J. , et al; TBNET. Risk assessment of tuberculosis in immunocompromised patients. A TBNET study. Am J Respir Crit Care Med 2014; 190 (10) 1168-1176
    CrossrefPubMedGoogle Scholar
  • 27 Igari H, Imasawa T, Noguchi N. , et al. Advanced stage of chronic kidney disease is risk of poor treatment outcome for smear-positive pulmonary tuberculosis. J Infect Chemother 2015; 21 (08) 559-563
    CrossrefPubMedGoogle Scholar
  • 28 World Health Organization. Pediatric HIV Data and Statistics. 2013 . Available at: http://www.who.int/hiv/topics/paediatric/data/en/ . Accessed July 2016
    PubMedGoogle Scholar
  • 29 Fabian J, Naicker S. HIV and kidney disease in Sub-Saharan Africa. Nat Rev Nephrol 2009; 5 (10) 591-598
    PubMedGoogle Scholar
  • 30 Nourse PJ, Cotton MF, Bates WD. Renal manifestations in children co-infected with HIV and disseminated tuberculosis. Pediatr Nephrol 2010; 25 (09) 1759-1763
    CrossrefPubMedGoogle Scholar
  • 31 Ray PE, Hu CA. Advances in our understanding of the pathogenesis of HIV-1 associated nephropathy in children. Future Virol 2011; 6 (07) 883-894
    CrossrefPubMedGoogle Scholar
  • 32 Gray DM, Zar HJ. Community-acquired pneumonia in HIV-infected children: a global perspective. Curr Opin Pulm Med 2010; 16 (03) 208-216
    PubMedGoogle Scholar
  • 33 Anochie IC, Eke FU, Okpere AN. Human immunodeficiency virus-associated nephropathy (HIVAN) in Nigerian children. Pediatr Nephrol 2008; 23 (01) 117-122
    CrossrefPubMedGoogle Scholar
  • 34 Lucas GM, Ross MJ, Stock PG. , et al; HIV Medicine Association of the Infectious Diseases Society of America. Clinical practice guideline for the management of chronic kidney disease in patients infected with HIV: 2014 update by the HIV Medicine Association of the Infectious Diseases Society of America. Clin Infect Dis 2014; 59 (09) e96-e138
    CrossrefPubMedGoogle Scholar
  • 35 Ravani P, Palmer SC, Oliver MJ. , et al. Associations between hemodialysis access type and clinical outcomes: a systematic review. J Am Soc Nephrol 2013; 24 (03) 465-473
    CrossrefPubMedGoogle Scholar
  • 36 Kaze FF, Ashuntantang G, Halle MP, Kengne AP. Outcomes of non-tunneled non-cuffed hemodialysis catheters in patients on chronic hemodialysis in a resource limited Sub-Saharan Africa setting. Ther Apher Dial 2014; 18 (05) 455-460
    CrossrefPubMedGoogle Scholar
  • 37 Heidarieh P, Hashemi Shahraki A, Yaghoubfar R, Hajehasani A, Mirsaeidi M. Microbiological analysis of hemodialysis water in a developing country. ASAIO J 2016; 62 (03) 332-339
    CrossrefPubMedGoogle Scholar
  • 38 Shahryari A, Nikaeen M, Hatamzadeh M, Vahid Dastjerdi M, Hassanzadeh A. Evaluation of bacteriological and chemical qality of dialysis water and fluid in Isfahan, Central Iran. Iran J Public Health 2016; 45 (05) 650-656
    PubMedGoogle Scholar
  • 39 Ott JJ, Stevens GA, Groeger J, Wiersma ST. Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity. Vaccine 2012; 30 (12) 2212-2219
    CrossrefPubMedGoogle Scholar
  • 40 Sheth RD, Peskin MF, Du XL. The duration of hepatitis B vaccine immunity in pediatric dialysis patients. Pediatr Nephrol 2014; 29 (10) 2029-2037
    CrossrefPubMedGoogle Scholar
  • 41 (CDC) CfDCaP. Dialysis Safety: Guidelines and Recommendations. 2016 . Available at: http://www.cdc.gov/dialysis/guidelines/ . Accessed on December 7, 2016
    PubMedGoogle Scholar
  • 42 Fissell RB, Bragg-Gresham JL, Woods JD. , et al. Patterns of hepatitis C prevalence and seroconversion in hemodialysis units from three continents: the DOPPS. Kidney Int 2004; 65 (06) 2335-2342
    CrossrefPubMedGoogle Scholar
  • 43 Fabrizi F, Lunghi G, Ganeshan SV, Martin P, Messa P. Hepatitis C virus infection and the dialysis patient. Semin Dial 2007; 20 (05) 416-422
    CrossrefPubMedGoogle Scholar
  • 44 Nguyen DB, Gutowski J, Ghiselli M. , et al. A large outbreak of hepatitis C virus infections in a hemodialysis clinic. Infect Control Hosp Epidemiol 2016; 37 (02) 125-133
    CrossrefPubMedGoogle Scholar
  • 45 Agarwal SK, Dash SC, Gupta S, Pandey RM. Hepatitis C virus infection in haemodialysis: the ‘no-isolation’ policy should not be generalized. Nephron Clin Pract 2009; 111 (02) c133-c140
    CrossrefPubMedGoogle Scholar
  • 46 Ladino M, Pedraza F, Roth D. Hepatitis C virus infection in chronic kidney disease. J Am Soc Nephrol 2016; 27 (08) 2238-2246
    CrossrefPubMedGoogle Scholar
  • 47 Schaefer F, Feneberg R, Aksu N. , et al. Worldwide variation of dialysis-associated peritonitis in children. Kidney Int 2007; 72 (11) 1374-1379
    CrossrefPubMedGoogle Scholar
  • 48 Song Y, Wu J, Yan H, Chen J. Peritoneal dialysis-associated nontuberculous mycobacterium peritonitis: a systematic review of reported cases. Nephrol Dial Transplant 2012; 27 (04) 1639-1644
    CrossrefPubMedGoogle Scholar
  • 49 Warady BA, Bakkaloglu S, Newland J. , et al. Consensus guidelines for the prevention and treatment of catheter-related infections and peritonitis in pediatric patients receiving peritoneal dialysis: 2012 update. Perit Dial Int 2012; 32 (02) (Suppl. 02) S32-S86
    CrossrefPubMedGoogle Scholar