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Synthesis 2018; 50(06): 1301-1306
DOI: 10.1055/s-0036-1591866
DOI: 10.1055/s-0036-1591866
paper
Asymmetric Total Synthesis of (+)-Coprophilin
Further Information
Publication History
Received: 13 October 2017
Accepted after revision: 21 November 2017
Publication Date:
21 December 2017 (online)
Abstract
In this paper, we report the first total synthesis of (+)-coprophilin, an anticoccidial agent, by constructing the chiral linear precursor via a Mukaiyama–Evans aldol reaction and a stereoselective intramolecular Diels–Alder reaction. The proposed method can be used to provide large amounts of (+)-coprophilin, which exhibits a 3,4,5,6,7-pentasubstituted Δ1,2-octalin core structure.
Key words
total synthesis - stereoselective synthesis - antibiotics - Diels–Alder reaction - aldol reactionSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1591866.
- Supporting Information
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For related biological studies using synthetic AMF-26 (M-COPA), see: