Copper-Free Double Silylation of 1,2-Dibromobenzenes Using a Mg/LiCl/DMI System

Abstract

The reaction of 1,2-dibromobenzenes with chlorotrimethylsilane efficiently proceeded in the presence of Mg and LiCl in DMI under mild conditions, giving 1,2-bis(trimethylsilyl)benzenes in good to high yields. The reaction of 1,2-dibromobenzenes with chlorodimethylsilane under the same conditions afforded the corresponding 1,2-bis(dimethylsilyl)benzenes in high yields. Functional group transformations of 1,2-bis(trimethylsilyl)benzene were conducted to demonstrate the synthetic utility.

Key words

copper-free reaction - double silylation - 1,2-bis(trimethylsilyl)benzenes - mild conditions - 1,2-dibromobenzenes - Mg/LiCl/DMI system

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