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Synthesis 2017; 49(24): 5357-5363
DOI: 10.1055/s-0036-1588566
DOI: 10.1055/s-0036-1588566
paper
A Rh(III)-Catalyzed Cascade C–H Functionalization/C(sp3)–C(sp3) Formation/Cyclization Reaction for the Synthesis of Isoquinolinedione Derivatives
Financial support from the National Natural Science Foundation of China (No. 21372195) is gratefully acknowledged.Further Information
Publication History
Received: 03 August 2017
Accepted after revision: 18 August 2017
Publication Date:
25 September 2017 (online)
Abstract
A cascade C–H functionalization/C(sp3)–C(sp3) formation/cyclization reaction of N-methoxybenzamides with diazomalonates under rhodium(III) catalysis is developed for the efficient synthesis of isoquinolinedione derivatives. A plausible mechanism involving double migratory insertions of carbenes for the formation of C(sp2)–C(sp3) and C(sp3)–C(sp3) bonds by rhodium(III) catalysis is also proposed.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1588566.
- Supporting Information
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For reviews on C–H functionalizations by metal carbene insertions, see: