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Synthesis 2017; 49(07): 1675-1679
DOI: 10.1055/s-0036-1588115
DOI: 10.1055/s-0036-1588115
paper
Palladium-Catalyzed Decarboxylative Cross-Coupling of 1,3,4-Oxadiazoles with Alkynoic Acids: A Simple Route for the Preparation of 2-Alkynylated 1,3,4-Oxadiazoles
Further Information
Publication History
Received: 07 September 2016
Accepted after revision: 11 November 2016
Publication Date:
15 December 2016 (online)
Abstract
For the first time 2-alk-1-ynyl-5-(het)aryl-1,3,4-oxadiazole derivatives have been synthesized by the decarboxylative cross-coupling of alk-2-ynoic acids with 2-(het)aryl-1,3,4-oxadiazoles, employing palladium(II) chloride as the catalyst and silver(I) oxide as an oxidant with 1,3-bis(diphenylphosphanyl)propane as a ligand. Products were formed in high yields with no byproduct.
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