J Neurol Surg B Skull Base 2016; 77(04): 371-378
DOI: 10.1055/s-0036-1581138
NASBS Noteworthy Panel
Georg Thieme Verlag KG Stuttgart · New York

Multimodality Management of Trigeminal Schwannomas

Ajay Niranjan
1   Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States
,
Samuel Barnett
2   Department of Neurological Surgery, UT Southwestern Medical Center, Dallas, Texas, United States
,
Vijay Anand
3   Department of Otolaryngology-Head and Neck Surgery, Weill Cornell Medical College, New York, New York, United States
,
Siviero Agazzi
4   Department of Neurosurgery, University of South Florida, Tampa, Florida, United States
› Author Affiliations
Further Information

Publication History

07 November 2015

17 February 2016

Publication Date:
22 April 2016 (online)

Abstract

Patients presenting with trigeminal schwannomas require multimodality management by a skull base surgical team that can offer expertise in both transcranial and transnasal approaches as well as radiosurgical and microsurgical strategies. Improvement in neurologic symptoms, preservation of cranial nerve function, and control of mass effect are the primary goals of management for trigeminal schwannomas. Complete surgical resection is the treatment of choice but may not be possible in all cases. Radiosurgery is an option as primary management for small- to moderate-sized tumors and can be used for postoperative residuals or recurrences. Planned surgical resection followed by SRS for residual tumor is an effective option for larger trigeminal schwannomas. The endoscopic resection is an excellent approach for patients with an extradural tumor or tumors isolated to the Meckel cave. A detailed analysis of a tumor and its surroundings based on high-quality imaging can help better estimate the expected outcome from each treatment. An expert skull base team should be able to provide precise counseling for each patient's situation for selecting the best option.

Note

This article is based on the Panel discussion “Trigeminal Schwannomas” at the 2015 NASBS Annual Meeting.


 
  • References

  • 1 Pamir MN, Peker S, Bayrakli F, Kiliç T, Ozek MM. Surgical treatment of trigeminal schwannomas. Neurosurg Rev 2007; 30 (4) 329-337 , discussion 337
  • 2 Day JD, Fukushima T. The surgical management of trigeminal neuromas. Neurosurgery 1998; 42 (2) 233-240 , discussion 240–241
  • 3 Jefferson G. The trigeminal neurinomas with some remarks on malignant invasion of the gasserian ganglion. Clin Neurosurg 1953; 1: 11-54
  • 4 Samii M, Alimohamadi M, Gerganov V. Endoscope-assisted retrosigmoid intradural suprameatal approach for surgical treatment of trigeminal schwannomas. Neurosurgery 2014; 10 (Suppl. 04) 565-575 , discussion 575
  • 5 Yoshida K, Kawase T. Trigeminal neurinomas extending into multiple fossae: surgical methods and review of the literature. J Neurosurg 1999; 91 (2) 202-211
  • 6 Chen LF, Yang Y, Yu XG , et al. Operative management of trigeminal neuromas: an analysis of a surgical experience with 55 cases. Acta Neurochir (Wien) 2014; 156 (6) 1105-1114
  • 7 Goel A, Muzumdar D, Raman C. Trigeminal neuroma: analysis of surgical experience with 73 cases. Neurosurgery 2003; 52 (4) 783-790 , discussion 790
  • 8 Wanibuchi M, Fukushima T, Zomordi AR, Nonaka Y, Friedman AH. Trigeminal schwannomas: skull base approaches and operative results in 105 patients. Neurosurgery 2012; 70 (1, Suppl Operative) 132-143 , discussion 143–144
  • 9 O'Reilly BF, Mehanna H, Kishore A, Crowther JA. Growth rate of non-vestibular intracranial schwannomas. Clin Otolaryngol Allied Sci 2004; 29 (1) 94-97
  • 10 Fisher LM, Doherty JK, Lev MH, Slattery III WH. Distribution of nonvestibular cranial nerve schwannomas in neurofibromatosis 2. Otol Neurotol 2007; 28 (8) 1083-1090
  • 11 Janjua RM, Wong KM, Parekh A, van Loveren HR. Management of the great mimicker: Meckel cave tumors. Neurosurgery 2010; 67 (2, Suppl Operative ): 416-421
  • 12 Sindou M, Chavez JM, Saint Pierre G, Jouvet A. Percutaneous biopsy of cavernous sinus tumors through the foramen ovale. Neurosurgery 1997; 40 (1) 106-110 , discussion 110–111
  • 13 Agazzi S, Chang S, Drucker MD, Youssef AS, Van Loveren HR. Sudden blindness as a complication of percutaneous trigeminal procedures: mechanism analysis and prevention. J Neurosurg 2009; 110 (4) 638-641
  • 14 Raza SM, Donaldson AM, Mehta A, Tsiouris AJ, Anand VK, Schwartz TH. Surgical management of trigeminal schwannomas: defining the role for endoscopic endonasal approaches. Neurosurg Focus 2014; 37 (4) E17
  • 15 Al-Mefty O, Ayoubi S, Gaber E. Trigeminal schwannomas: removal of dumbbell-shaped tumors through the expanded Meckel cave and outcomes of cranial nerve function. J Neurosurg 2002; 96 (3) 453-463
  • 16 Jeong SK, Lee EJ, Hue YH, Cho YH, Kim JH, Kim CJ. A suggestion of modified classification of trigeminal schwannomas according to location, shape, and extension. Brain Tumor Res Treat 2014; 2 (2) 62-68
  • 17 Fukaya R, Yoshida K, Ohira T, Kawase T. Trigeminal schwannomas: experience with 57 cases and a review of the literature. Neurosurg Rev 2010; 34 (2) 159-171
  • 18 Sharma BS, Ahmad FU, Chandra PS, Mahapatra AK. Trigeminal schwannomas: experience with 68 cases. J Clin Neurosci 2008; 15 (7) 738-743
  • 19 McCormick PC, Bello JA, Post KD. Trigeminal schwannoma. Surgical series of 14 cases with review of the literature. J Neurosurg 1988; 69 (6) 850-860
  • 20 Pollack IF, Sekhar LN, Jannetta PJ, Janecka IP. Neurilemomas of the trigeminal nerve. J Neurosurg 1989; 70 (5) 737-745
  • 21 Dolenc VV. Frontotemporal epidural approach to trigeminal neurinomas. Acta Neurochir (Wien) 1994; 130 (1–4) 55-65
  • 22 Konovalov AN, Spallone A, Mukhamedjanov DJ, Tcherekajev VA, Makhmudov UB. Trigeminal neurinomas. A series of 111 surgical cases from a single institution. Acta Neurochir (Wien) 1996; 138 (9) 1027-1035
  • 23 Moffat D, De R, Hardy D, Moumoulidis I. Surgical management of trigeminal neuromas: a report of eight cases. J Laryngol Otol 2006; 120 (8) 631-637
  • 24 Huang CF, Kondziolka D, Flickinger JC, Lunsford LD. Stereotactic radiosurgery for trigeminal schwannomas. Neurosurgery 1999; 45 (1) 11-16 , discussion 16
  • 25 Nettel B, Niranjan A, Martin JJ , et al. Gamma knife radiosurgery for trigeminal schwannomas. Surg Neurol 2004; 62 (5) 435-444 , discussion 444–446
  • 26 Pan L, Wang EM, Zhang N , et al. Long-term results of Leksell gamma knife surgery for trigeminal schwannomas. J Neurosurg 2005; 102 (Suppl): 220-224
  • 27 Sun S, Liu A, Wang C, Luo B, Wang M. Clinical analysis of gamma knife surgery for trigeminal schwannomas. J Neurosurg 2006; 105 (Suppl): 144-148
  • 28 Peker S, Bayrakli F, Kiliç T, Pamir MN. Gamma-knife radiosurgery in the treatment of trigeminal schwannomas. Acta Neurochir (Wien) 2007; 149 (11) 1133-1137 , discussion 1137
  • 29 Hasegawa T, Kida Y, Yoshimoto M, Koike J. Trigeminal schwannomas: results of gamma knife surgery in 37 cases. J Neurosurg 2007; 106 (1) 18-23
  • 30 Sheehan J, Yen CP, Arkha Y, Schlesinger D, Steiner L. Gamma knife surgery for trigeminal schwannoma. J Neurosurg 2007; 106 (5) 839-845
  • 31 Phi JH, Paek SH, Chung HT , et al. Gamma knife surgery and trigeminal schwannoma: is it possible to preserve cranial nerve function?. J Neurosurg 2007; 107 (4) 727-732
  • 32 Kano H, Niranjan A, Kondziolka D, Flickinger JC, Dade Lunsford L. Stereotactic radiosurgery for trigeminal schwannoma: tumor control and functional preservation clinical article. J Neurosurg 2009; 110 (3) 553-558
  • 33 Sun J, Zhang J, Yu X , et al. Stereotactic radiosurgery for trigeminal schwannoma: a clinical retrospective study in 52 cases. Stereotact Funct Neurosurg 2013; 91 (4) 236-242
  • 34 Mabanta SR, Buatti JM, Friedman WA, Meeks SL, Mendenhall WM, Bova FJ. Linear accelerator radiosurgery for nonacoustic schwannomas. Int J Radiat Oncol Biol Phys 1999; 43 (3) 545-548
  • 35 Yianni J, Dinca EB, Rowe J, Radatz M, Kemeny AA. Stereotactic radiosurgery for trigeminal schwannomas. Acta Neurochir (Wien) 2012; 154 (2) 277-283
  • 36 Sharma MS, Kondziolka D, Khan A , et al. Radiation tolerance limits of the brainstem. Neurosurgery 2008; 63 (4) 728-732 , discussion 732–733
  • 37 Wallner KE, Pitts LH, Davis RL, Sheline GE. Radiation therapy for the treatment of non-eight nerve intracranial neurilemmoma. Int J Radiat Oncol Biol Phys 1988; 14 (2) 287-290
  • 38 Zabel A, Debus J, Thilmann C, Schlegel W, Wannenmacher M. Management of benign cranial nonacoustic schwannomas by fractionated stereotactic radiotherapy. Int J Cancer 2001; 96 (6) 356-362
  • 39 Nishioka K, Abo D, Aoyama H , et al. Stereotactic radiotherapy for intracranial nonacoustic schwannomas including facial nerve schwannoma. Int J Radiat Oncol Biol Phys 2009; 75 (5) 1415-1419