Am J Perinatol 2016; 33(05): 473-479
DOI: 10.1055/s-0035-1566308
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Can Transabdominal Cervical Length Measurement Exclude Short Cervix?

Janine S. Rhoades
1   Department of Obstetrics and Gynecology, Washington University in St. Louis, St. Louis, Missouri
,
Jennifer M. Park
2   Department of Obstetrics and Gynecology, Hartford Hospital, Hartford, Connecticut
,
Molly J. Stout
1   Department of Obstetrics and Gynecology, Washington University in St. Louis, St. Louis, Missouri
,
George A. Macones
1   Department of Obstetrics and Gynecology, Washington University in St. Louis, St. Louis, Missouri
,
Alison G. Cahill
1   Department of Obstetrics and Gynecology, Washington University in St. Louis, St. Louis, Missouri
,
Methodius G. Tuuli
1   Department of Obstetrics and Gynecology, Washington University in St. Louis, St. Louis, Missouri
› Author Affiliations
Further Information

Publication History

19 August 2015

01 October 2015

Publication Date:
02 November 2015 (online)

Abstract

Objective This study aims to determine if transabdominal (TA) cervical length may be used to rule out a short cervix on transvaginal (TV) ultrasound.

Study Design We conducted a prospective cohort study of women undergoing routine anatomic survey at 17 to 23 weeks gestation. TA and TV cervical length measurements were obtained in each patient. A short cervix was defined as TV cervical length < 30 mm. Predictive characteristics were calculated for different cutoff values of TA cervical length.

Results There were 404 patients enrolled, a TA cervical length could not be obtained in 83 women (20.6%) and 318 women had both TA and TV measurements. Of those, 14 (4.4%) had a TV cervical length < 30 mm. TA cervical length measurement ≥ 35 mm excluded the possibility of TV cervical length < 30 mm (negative predictive value, 99.5%; 95% confidence interval [CI], 97.4; 100%). In our cohort, 67.6% (95% CI, 62.2; 72.7%) of TV ultrasounds could have been avoided using a TA cervical length cutoff of ≥ 35 mm.

Conclusion ATA cervical length of at least 35 mm excludes a short cervix of < 30 mm. While TA cervical length screening may not be feasible in 1 in 5 women, it may be used to decrease the burden of universal TV cervical length screening.

This article was presented at the 35th Annual Meeting of the Society for Maternal–Fetal Medicine: The Pregnancy Meeting; February 02–07, 2015; San Diego, CA.


 
  • References

  • 1 Matthews TJ, MacDorman MF. Infant mortality statistics from the 2010 period linked birth/infant death data set. Natl Vital Stat Rep 2013; 62 (8) 1-26
  • 2 Iams JD, Goldenberg RL, Meis PJ , et al; National Institute of Child Health and Human Development Maternal Fetal Medicine Unit Network. The length of the cervix and the risk of spontaneous premature delivery. N Engl J Med 1996; 334 (9) 567-572
  • 3 Hassan SS, Romero R, Berry SM , et al. Patients with an ultrasonographic cervical length < or =15 mm have nearly a 50% risk of early spontaneous preterm delivery. Am J Obstet Gynecol 2000; 182 (6) 1458-1467
  • 4 Fonseca EB, Celik E, Parra M, Singh M, Nicolaides KH ; Fetal Medicine Foundation Second Trimester Screening Group. Progesterone and the risk of preterm birth among women with a short cervix. N Engl J Med 2007; 357 (5) 462-469
  • 5 Hassan SS, Romero R, Vidyadhari D , et al; PREGNANT Trial. Vaginal progesterone reduces the rate of preterm birth in women with a sonographic short cervix: a multicenter, randomized, double-blind, placebo-controlled trial. Ultrasound Obstet Gynecol 2011; 38 (1) 18-31
  • 6 Berghella V, Rafael TJ, Szychowski JM, Rust OA, Owen J. Cerclage for short cervix on ultrasonography in women with singleton gestations and previous preterm birth: a meta-analysis. Obstet Gynecol 2011; 117 (3) 663-671
  • 7 Cahill AG, Odibo AO, Caughey AB , et al. Universal cervical length screening and treatment with vaginal progesterone to prevent preterm birth: a decision and economic analysis. Am J Obstet Gynecol 2010; 202 (6) 548.e1-548.e8
  • 8 Miller ES, Grobman WA. Cost-effectiveness of transabdominal ultrasound for cervical length screening for preterm birth prevention. Am J Obstet Gynecol 2013; 209 (6) 546.e1-546.e6
  • 9 Saul LL, Kurtzman JT, Hagemann C, Ghamsary M, Wing DA. Is transabdominal sonography of the cervix after voiding a reliable method of cervical length assessment?. J Ultrasound Med 2008; 27 (9) 1305-1311
  • 10 Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986; 1 (8476) 307-310
  • 11 DeLong ER, DeLong DM, Clarke-Pearson DL. Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 1988; 44 (3) 837-845
  • 12 Roh HJ, Ji YI, Jung CH, Jeon GH, Chun S, Cho HJ. Comparison of cervical lengths using transabdominal and transvaginal sonography in midpregnancy. J Ultrasound Med 2013; 32 (10) 1721-1728
  • 13 Stone PR, Chan EHY, McCowan LME, Taylor RS, Mitchell JM ; SCOPE Consortium. Transabdominal scanning of the cervix at the 20-week morphology scan: comparison with transvaginal cervical measurements in a healthy nulliparous population. Aust N Z J Obstet Gynaecol 2010; 50 (6) 523-527
  • 14 Hernandez-Andrade E, Romero R, Ahn H , et al. Transabdominal evaluation of uterine cervical length during pregnancy fails to identify a substantial number of women with a short cervix. J Matern Fetal Neonatal Med 2012; 25 (9) 1682-1689
  • 15 Friedman AM, Srinivas SK, Parry S, Elovitz MA, Wang E, Schwartz N. Can transabdominal ultrasound be used as a screening test for short cervical length?. Am J Obstet Gynecol 2013; 208 (3) 190.e1-190.e7
  • 16 To MS, Skentou C, Cicero S, Nicolaides KH. Cervical assessment at the routine 23-weeks' scan: problems with transabdominal sonography. Ultrasound Obstet Gynecol 2000; 15 (4) 292-296
  • 17 Chaudhury K, Ghosh M, Halder A, Senapati S, Chaudhury S. Is transabdominal ultrasound scanning of cervical measurement in mid-trimester pregnancy a useful alternative to transvaginal ultrasound scan?. J Turk Ger Gynecol Assoc 2013; 14 (4) 225-229
  • 18 Iams JD, Grobman WA, Lozitska A , et al; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal–Fetal Medicine Units Network. Adherence to criteria for transvaginal ultrasound imaging and measurement of cervical length. Am J Obstet Gynecol 2013; 209 (4) 365.e1-365.e5