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Synthesis 2016; 48(17): 2781-2788
DOI: 10.1055/s-0035-15661438
DOI: 10.1055/s-0035-15661438
special topic
Selective C(8)–H Activation of Imidazopyridines Mediated by Cooperative Nickel–Aluminum Catalysis
Further Information
Publication History
Received: 23 February 2016
Accepted after revision: 17 March 2016
Publication Date:
15 June 2016 (online)
This work is dedicated to the victims of the recent Tainan earthquake.
Abstract
A catalytic paradigm is described featuring a synergistic interaction between nickel, aluminum and different ligands to impart a rather remote C–H alkenylation of imidazo[1,5-a]pyridines at the C-8 position without the necessity of installing a directing group. The scope of the direct C–H activation reactions of various 5-aryl- and 3-arylimidazopyridines is established using different sterically hindered alkynes.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1561438.
- Supporting Information
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