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Int J Sports Med 2016; 37(04): 274-281
DOI: 10.1055/s-0035-1564259
Clinical Sciences
© Georg Thieme Verlag KG Stuttgart · New York

Effects of Simultaneous or Sequential Weight Loss Diet and Aerobic Interval Training on Metabolic Syndrome

R. Mora-Rodriguez
1   Exercise Physiology Laboratory, University of Castilla-La Mancha, Toledo, Spain
,
J. F. Ortega
1   Exercise Physiology Laboratory, University of Castilla-La Mancha, Toledo, Spain
,
V. Guio de Prada
2   Sports Medicine Center, Diputacion de Toledo, Toledo, Spain
,
V. E. Fernández-Elías
1   Exercise Physiology Laboratory, University of Castilla-La Mancha, Toledo, Spain
,
N. Hamouti
1   Exercise Physiology Laboratory, University of Castilla-La Mancha, Toledo, Spain
,
F. Morales-Palomo
1   Exercise Physiology Laboratory, University of Castilla-La Mancha, Toledo, Spain
,
V. Martinez-Vizcaino
3   Health and Social Research Center, Universidad de Castilla-La Mancha, Cuenca, Spain
,
R. K. Nelson
4   College of Health Professions, Central Michigan University, Mt Pleasant, United States
› Author Affiliations
Further Information

Publication History



accepted after revision 10 September 2015

Publication Date:
14 December 2015 (online)

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Abstract

Our purpose in this study was to investigate efficient and sustainable combinations of exercise and diet-induced weight loss (DIET), in order to combat obesity in metabolic syndrome (MetS) patients. We examined the impact of aerobic interval training (AIT), followed by or concurrent to a DIET on MetS components. 36 MetS patients (54±9 years old; 33±4 BMI; 27 males and 9 females) underwent 16 weeks of AIT followed by another 16 weeks without exercise from the fall of 2013 to the spring of 2014. Participants were randomized to AIT without DIET (E CON, n=12), AIT followed by DIET (E-then-D, n=12) or AIT concurrent with DIET (E+D, n=12) groups. Body weight decreased below E CON similarly in the E-then-D and E+D groups (~5%). Training improved blood pressure and cardiorespiratory fitness (VO2peak) in all groups with no additional effect of concurrent weight loss. However, E+D improved insulin sensitivity (HOMA) and lowered plasma triglycerides and blood cholesterol below E CON and E-then-D (all P<0.05). Weight loss in E-then-D in the 16 weeks without exercise lowered HOMA to the E+D levels and maintained blood pressure at trained levels. Our data suggest that a new lifestyle combination consisting of aerobic interval training followed by weight loss diet is similar, or even more effective on improving metabolic syndrome factors than concurrent exercise plus diet.

Key words

high intensity interval training - weight-reducing diet - metabolic syndrome - insulin resistance - maximal fat oxidation - DXA
 

  • References

  • 1 Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WP, Loria CM, Smith SCJ. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009. 120. 1640-1645
    Google Scholar
  • 2 Armstrong LE, Balady GJ, Berry MJ, Davis SE, Davy BM, Davy KP, Franklin BA, Gordon NF, Lee I-M, McConnell T, Myers JN, Pizza FX, Rowland TW, Steward K, Thompson PD, Wallace JP. ACSM guidelines for exercise testing and prescription. 7th ed. Baltimore MD: Lippincott, Williams and Wilkins; 2006
    Google Scholar
  • 3 Bateman LA, Slentz CA, Willis LH, Tamlyn Shields A, Piner LW, Bales CW, Houmard JA, Kraus WE. Comparison of aerobic versus resistance exercise training effects on metabolic syndrome (from the studies of a targeted risk reduction intervention through defined exercise -STRRIDE-AT/RT). Am J Cardiol 2011; 108: 838-844
    CrossrefPubMedGoogle Scholar
  • 4 Case CC, Jones PH, Nelson K, O'Brian Smith E, Ballantyne CM. Impact of weight loss on the metabolic syndrome. Diabetes Obes Metab 2002; 4: 407-414
    CrossrefPubMedGoogle Scholar
  • 5 Cohen J. Statistical Power Analysis for the Behavioural Sciences. In: 2nd ed. New Jersey: Lawrence Erlbaum Associates; 1988: 569
    Google Scholar
  • 6 Costill DL, Sherman WM, Fink WJ, Maresh C, Witten M, Miller JM. The role of dietary carbohydrates in muscle glycogen resynthesis after strenuous running. Am J Clin Nutr 1981; 34: 1831-1836
    PubMedGoogle Scholar
  • 7 Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972; 18: 499-502
    CrossrefPubMedGoogle Scholar
  • 8 Grundy SM, Hansen B, Smith Jr SC, Cleeman JI, Kahn RA. American Heart A, National Heart L, Blood I, American Diabetes A . Clinical management of metabolic syndrome: report of the American Heart Association/National Heart, Lung, and Blood Institute/American Diabetes Association conference on scientific issues related to management. Circulation 2004; 109: 551-556
    CrossrefPubMedGoogle Scholar
  • 9 Hagan RD, Upton SJ, Wong L, Whittam J. The effects of aerobic conditioning and/or caloric restriction in overweight men and women. Med Sci Sports Exerc 1986; 18: 87-94
    PubMedGoogle Scholar
  • 10 Hamman RF, Wing RR, Edelstein SL, Lachin JM, Bray GA, Delahanty L, Hoskin M, Kriska AM, Mayer-Davis EJ, Pi-Sunyer X, Regensteiner J, Venditti B, Wylie-Rosett J. Effect of weight loss with lifestyle intervention on risk of diabetes. Diabetes Care 2006; 29: 2102-2107
    CrossrefPubMedGoogle Scholar
  • 11 Harriss DJ, Atkinson G. Ethical standards in sport and exercise science research: 2014 update. Int J Sports Med 2013; 34: 1025-1028
    Article in Thieme ConnectPubMedGoogle Scholar
  • 12 Helgerud J, Hkydal K, Wang E, Karlsen T, Berg P, Bjerkaas M, Simonsen T, Helgesen C, Hjorth N, Bach R, Hoff J. Aerobic high-intensity intervals improve VO2max more than moderate training. Med Sci Sports Exerc 2007; 39: 665-671
    CrossrefPubMedGoogle Scholar
  • 13 Houmard JA, Tanner CJ, Slentz CA, Duscha BD, McCartney JS, Kraus WE. Effect of the volume and intensity of exercise training on insulin sensitivity. J Appl Physiol 2004; 96: 101-106
    CrossrefPubMedGoogle Scholar
  • 14 Jakicic JM, Rickman AD, Lang W, Davis KK, Gibbs BB, Neiberg R, Marcus MD. Time-based physical activity interventions for weight loss: a randomized trial. Med Sci Sports Exerc 2015; 47: 1061-1069
    CrossrefPubMedGoogle Scholar
  • 15 Johnson JL, Slentz CA, Houmard JA, Samsa GP, Duscha BD, Aiken LB, McCartney JS, Tanner CJ, Kraus WE. Exercise training amount and intensity effects on metabolic syndrome (from Studies of a Targeted Risk Reduction Intervention through Defined Exercise). Am J Cardiol 2007; 100: 1759-1766
    CrossrefPubMedGoogle Scholar
  • 16 Kelley DE, He J, Menshikova EV, Ritov VB. Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 2002; 51: 2944-2950
    CrossrefPubMedGoogle Scholar
  • 17 Lee CD, Blair SN, Jackson AS. Cardiorespiratory fitness, body composition, and all-cause and cardiovascular disease mortality in men. Am J Clin Nutr 1999; 69: 373-380
    CrossrefPubMedGoogle Scholar
  • 18 Zimmet P, Magliano D, Matsuzawa Y, Alberti G, Shaw J. The metabolic syndrome: a global public health problem and a new definition. J Atheroscler Thromb 2005; 12: 295-300
    CrossrefPubMedGoogle Scholar
  • 19 Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419
    Google Scholar
  • 20 Mora-Rodriguez R, Ortega JF, Hamouti N, Fernandez-Elias VE, Canete Garcia-Prieto J, Guadalupe-Grau A, Saborido A, Martin-Garcia M, Ara I, Martinez-Vizcaino V. Time-course effects of aerobic interval training and detraining in patients with metabolic syndrome. Nutr Metab Cardiovasc Dis 2014; 24: 792-798
    CrossrefPubMedGoogle Scholar
  • 21 Muzio F, Mondazzi L, Sommariva D, Branchi A. Long-term effects of low-calorie diet on the metabolic syndrome in obese nondiabetic patients. Diabetes Care 2005; 28: 1485-1486
    CrossrefPubMedGoogle Scholar
  • 22 Newsom SA, Schenk S, Thomas KM, Harber MP, Knuth ND, Goldenberg N, Horowitz JF. Energy deficit after exercise augments lipid mobilization but does not contribute to the exercise-induced increase in insulin sensitivity. J Appl Physiol 2010; 108: 554-560
    CrossrefPubMedGoogle Scholar
  • 23 Ortega JF, Fernandez-Elias VE, Hamouti N, Garcia-Pallares J, Mora-Rodriguez R. Higher Insulin-sensitizing Response after Sprint Interval Compared to Continuous Exercise. Int J Sports Med 2015; 36: 209-214
    Article in Thieme ConnectPubMedGoogle Scholar
  • 24 Perri MG, Anton SD, Durning PE, Ketterson TU, Sydeman SJ, Berlant NE, Kanasky Jr WF, Newton Jr RL, Limacher MC, Martin AD. Adherence to exercise prescriptions: effects of prescribing moderate versus higher levels of intensity and frequency. Health Psychol 2002; 21: 452-458
    CrossrefPubMedGoogle Scholar
  • 25 Phelan S, Wadden TA, Berkowitz RI, Sarwer DB, Womble LG, Cato RK, Rothman R. Impact of weight loss on the metabolic syndrome. Int J Obes (Lond) 2007; 31: 1442-1448
    CrossrefPubMedGoogle Scholar
  • 26 Rice B, Janssen I, Hudson R, Ross R. Effects of aerobic or resistance exercise and/or diet on glucose tolerance and plasma insulin levels in obese men. Diabetes Care 1999; 22: 684-691
    CrossrefPubMedGoogle Scholar
  • 27 Ritov VB, Menshikova EV, Azuma K, Wood RJ, Toledo FG, Goodpaster BH, Ruderman NB, Kelley DE. Deficiency of electron transport chain in human skeletal muscle mitochondria in type 2 diabetes mellitus and obesity. Am J Physiol 2010; 298: E49-E58
    PubMedGoogle Scholar
  • 28 Schenk S, Harber MP, Shrivastava CR, Burant CF, Horowitz JF. Improved insulin sensitivity after weight loss and exercise training is mediated by a reduction in plasma fatty acid mobilization, not enhanced oxidative capacity. J Physiol 2009; 587: 4949-4961
    CrossrefPubMedGoogle Scholar
  • 29 Stensvold D, Tjonna AE, Skaug EA, Aspenes S, Stolen T, Wisloff U, Slordahl SA. Strength training versus aerobic interval training to modify risk factors of metabolic syndrome. J Appl Physiol 2010; 108: 804-810
    CrossrefPubMedGoogle Scholar
  • 30 Straznicky NE, Grima MT, Eikelis N, Nestel PJ, Dawood T, Schlaich MP, Chopra R, Masuo K, Esler MD, Sari CI, Lambert GW, Lambert EA. The effects of weight loss versus weight loss maintenance on sympathetic nervous system activity and metabolic syndrome components. J Clin Endocrinol Metab 2011; 96: E503-E508
    CrossrefPubMedGoogle Scholar
  • 31 Stuart CA, South MA, Lee ML, McCurry MP, Howell ME, Ramsey MW, Stone MH. Insulin responsiveness in metabolic syndrome after eight weeks of cycle training. Med Sci Sports Exerc 2013; 45: 2021-2029
    CrossrefPubMedGoogle Scholar
  • 32 Tjonna AE, Lee SJ, Rognmo O, Stolen TO, Bye A, Haram PM, Loennechen JP, Al-Share QY, Skogvoll E, Slordahl SA, Kemi OJ, Najjar SM, Wisloff U. Aerobic interval training versus continuous moderate exercise as a treatment for the metabolic syndrome: a pilot study. Circulation 2008; 118: 346-354
    CrossrefPubMedGoogle Scholar
  • 33 Vincent WJ. Statistics in Kinesiology. 2nd ed. Champaign, IL USA: Humand Kinetics; 1999
    Google Scholar
  • 34 Wang P, Menheere PP, Astrup A, Andersen MR, van Baak MA, Larsen TM, Jebb S, Kafatos A, Pfeiffer AF, Martinez JA, Handjieva-Darlenska T, Hlavaty P, Viguerie N, Langin D, Saris WH, Mariman EC. Diogenes c . Metabolic syndrome, circulating RBP4, testosterone, and SHBG predict weight regain at 6 months after weight loss in men. Obesity (Silver Spring) 2013; 21: 1997-2006
    CrossrefPubMedGoogle Scholar
  • 35 Wood PD, Stefanick ML, Dreon DM, Frey-Hewitt B, Garay SC, Williams PT, Superko HR, Fortmann SP, Albers JJ, Vranizan KM, Ellsworth NM, Terry RB, Haskell WL. Changes in plasma lipids and lipoproteins in overweight men during weight loss through dieting as compared with exercise. N Engl J Med 1988; 319: 1173-1179
    CrossrefPubMedGoogle Scholar