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Synthesis 2017; 49(01): 135-144
DOI: 10.1055/s-0035-1562792
DOI: 10.1055/s-0035-1562792
paper
On the Synthesis and Reactivity of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-ones
Further Information
Publication History
Received: 15 June 2016
Accepted after revision: 08 July 2016
Publication Date:
24 August 2016 (online)
Dedicated with respect and best wishes to our friend Dieter Enders on the occasion of his 70th birthday
Abstract
An improved, scalable synthetic route to the quinazolinone natural product 2,3-dihydropyrrolo[1,2-a]quinazolin-5(1H)-one is reported. The applicability of this method to analogue synthesis and the synthesis of related natural products is explored. Finally, reactivity of the scaffold to a variety of electrophilic reagents, generating products stereoselectively, is reported.
Key words
quinazolinone - alkaloid - 2,3-dihydropyrrolo[1,2-a]quinazolin-5(1H)-one - deoxyvasicinoneSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1562792.
- Supporting Information
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