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Synthesis 2016; 48(19): 3382-3392
DOI: 10.1055/s-0035-1562501
DOI: 10.1055/s-0035-1562501
paper
A Convenient Metal-Free Synthesis of (E)-3-Styrylisocoumarins through Annulation of (E)-1,4-Diarylenynes
Further Information
Publication History
Received: 17 May 2016
Accepted after revision: 30 May 2016
Publication Date:
04 July 2016 (online)
This manuscript is dedicated to the memory of Professor Jean-François Normant
Abstract
A metal-free procedure for the cyclization of (E)-1,4-diarylenynes is described. The reaction is promoted by a catalytic amount of p-toluenesulfonic acid and takes place in ethanol at 160 °C under microwave irradiation to afford stereoselectively (E)-3-styrylisocoumarins in good to excellent yields.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1562501.
- Supporting Information
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