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Synthesis 2015; 47(24): 3874-3880
DOI: 10.1055/s-0035-1560349
DOI: 10.1055/s-0035-1560349
paper
Copper-Mediated Intramolecular N–N Bond Coupling Using Cerium(IV) Sulfate as the Oxidant for the Synthesis of 5-Thio-Substituted 1,2,4-Triazoles
Further Information
Publication History
Received: 10 July 2015
Accepted after revision: 06 September 2015
Publication Date:
22 September 2015 (online)
Abstract
A method for copper(II)-mediated N–N bond formation of N-imidoylisothioureas has been developed for the synthesis of 1,2,4-triazoles. The reaction requires cerium(IV) sulfate as an oxidant and proceeds at room temperature. This approach provides access to a variety of substituted 1,2,4-triazoles.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1560349.
- Supporting Information
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