Antimicrobial resistance of bacterial strains isolated from respiratory tract of cystic fibrosis patients with CFTR I1234V mutation

Abstract

From the beginning of October 2002 until the end of April 2003, 72 samples from 36 cystic fibrosis patients were examined in the Microbiology Laboratory, Hamad Medical Corporation. One hundred and thirteen organisms were isolated and tested for their antimicrobial susceptibility pattern. Haemophilus influenzae, Staphylococcus aureus and Pseudomonas aeruginosa were the predominant pathogens. Ten percent of H. influenzae were β-lactamase producers and 57% were resistant to co-trimoxazole. No methicillin resistant S. aureus was isolated. P. aeruginosa strains, particularly the mucoid ones, showed high resistance to aminoglycosides, while drugs like aztreonam, ceftazidime, cefepime, piperacillin/tazobactam, imipenem, meropenem and ciprofloxacin, showed low-level resistance and are reliable for empirical therapy for infection with such organisms in our institute.

Keywords

Cystic fibrosis - CFTR I1234V mutation - antimicrobial resistance